| 富达投资FMR LLC |
| 0.12% | 0.11% | #73 | $28.67亿 | 8,102.0万股 | $21.60亿 | 7,798.1万股 | +303.9万股+3.90% | 加仓 |
| 贝莱德BlackRock, Inc. |
| 0.03% | 0.02% | #162 | $17.07亿 | 4,823.6万股 | $12.26亿 | 4,425.4万股 | +398.2万股+9.00% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| 0.08% | 0.04% | #96 | $15.07亿 | 4,259.3万股 | $6.71亿 | 4,432.3万股 | -173.0万股-3.90% | 减仓 |
| QVT Financial LP |
| 49.36% | 51.04% | #1 | $8.40亿 | 2,372.3万股 | $6.97亿 | 2,516.1万股 | -143.8万股-5.72% | 减仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| 0.02% | 0.01% | #206 | $7.83亿 | 2,212.3万股 | $5.73亿 | 2,068.1万股 | +144.3万股+6.98% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.03% | 0.03% | #151 | $7.66亿 | 2,164.1万股 | $5.50亿 | 1,983.9万股 | +180.3万股+9.09% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| 0.06% | 0.04% | #116 | $6.57亿 | 1,855.6万股 | $3.08亿 | 1,111.2万股 | +744.5万股+67.00% | 加仓 |
| 道富集团STATE STREET CORP |
| 0.02% | 0.02% | #190 | $6.30亿 | 1,779.6万股 | $4.48亿 | 1,618.7万股 | +160.9万股+9.94% | 加仓 |
| 瑞银集团UBS Group AG |
| 0.08% | 0.09% | #98 | $6.18亿 | 1,746.7万股 | $6.27亿 | 2,261.9万股 | -515.3万股-22.78% | 减仓 |
| 法伦资本FARALLON CAPITAL MANAGEMENT, L.L.C. |
| 2.34% | 1.53% | #15 | $5.06亿 | 1,430.9万股 | $2.68亿 | 967.5万股 | +463.4万股+47.90% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| 0.02% | 0.02% | #172 | $4.26亿 | 1,167.4万股 | $2.82亿 | 1,018.2万股 | +149.2万股+14.65% | 加仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.51% | 0.55% | #41 | $3.66亿 | 1,034.9万股 | $3.54亿 | 1,279.4万股 | -244.5万股-19.11% | 减仓 |
| 两海资本Two Seas Capital LP |
| 6.98% | 3.9% | #5 | $3.52亿 | 995.8万股 | $2.79亿 | 1,006.1万股 | -10.3万股-1.02% | 减仓 |
| 富国银行WELLS FARGO & COMPANY/MN |
| 0.06% | <0.01% | #117 | $3.44亿 | 972.1万股 | $731.2万 | 26.4万股 | +945.7万股+3,582.81% | 加仓 |
| Assenagon资产管理Assenagon Asset Management S.A. |
| 0.37% | 0.3% | #45 | $2.96亿 | 836.3万股 | $1.96亿 | 707.6万股 | +128.6万股+18.18% | 加仓 |
| 洞察顾问PERCEPTIVE ADVISORS LLC |
| 4.3% | 4.48% | #12 | $2.86亿 | 808.5万股 | $2.30亿 | 828.5万股 | -20.0万股-2.41% | 减仓 |
| Patient Square Capital LP |
| 43.97% | 40.13% | #2 | $2.84亿 | 802.1万股 | $2.26亿 | 816.6万股 | -14.5万股-1.78% | 减仓 |
| 景顺Invesco Ltd. |
| 0.02% | 0.03% | #178 | $2.67亿 | 753.1万股 | $1.78亿 | 643.9万股 | +109.2万股+16.96% | 加仓 |
| 简街集团JANE STREET GROUP, LLC |
| 0.02% | <0.01% | #176 | $2.63亿 | 743.0万股 | $3,298.0万 | 119.1万股 | +624.0万股+524.07% | 加仓 |
| Darwin Global Management, Ltd. |
| 6.23% | 4.76% | #6 | $2.34亿 | 674.7万股 | $1.80亿 | 679.7万股 | -5.0万股-0.74% | 减仓 |
| AQR资本管理AQR CAPITAL MANAGEMENT LLC |
| 0.08% | 0.07% | #93 | $2.34亿 | 663.4万股 | $1.62亿 | 594.7万股 | +68.7万股+11.55% | 加仓 |
| 维京全球投资VIKING GLOBAL INVESTORS LP |
| 0.63% | 0.52% | #35 | $2.22亿 | 627.1万股 | $1.84亿 | 665.2万股 | -38.1万股-5.73% | 减仓 |
| Rubric资本管理Rubric Capital Management LP |
| 1.95% | 1.47% | #18 | $2.12亿 | 600.0万股 | $1.39亿 | 500.0万股 | +100.0万股+20.00% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| 0.02% | 0.01% | #166 | $2.06亿 | 581.3万股 | $7,543.3万 | 272.3万股 | +309.0万股+113.47% | 加仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| 0.03% | 0.04% | #153 | $1.85亿 | 523.0万股 | $2.07亿 | 747.6万股 | -224.5万股-30.04% | 减仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.02% | 0.02% | #204 | $1.70亿 | 481.7万股 | $1.94亿 | 699.2万股 | -217.5万股-31.11% | 减仓 |
| 挪威央行投资管理NORGES BANK |
| 0.02% | 0.01% | #205 | $1.68亿 | 474.7万股 | $4,623.1万 | 458.2万股 | +16.6万股+3.62% | 加仓 |
| 贝克兄弟顾问BAKER BROS. ADVISORS LP |
| 0.84% | 0.77% | #29 | $1.67亿 | 471.7万股 | $1.35亿 | 486.8万股 | -15.1万股-3.10% | 减仓 |
| Point72资产管理Point72 Asset Management, L.P. |
| 0.18% | 0.03% | #63 | $1.59亿 | 449.6万股 | $2,700.8万 | 97.5万股 | +352.1万股+361.11% | 加仓 |
| 詹尼森联营JENNISON ASSOCIATES LLC |
| 0.1% | 0.06% | #88 | $1.59亿 | 448.2万股 | $8,262.4万 | 298.3万股 | +149.9万股+50.26% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| 0.01% | 0.01% | #244 | $1.54亿 | 434.1万股 | $8,763.8万 | 316.4万股 | +117.8万股+37.22% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| 0.02% | 0.01% | #218 | $1.33亿 | 376.2万股 | $9,751.7万 | 352.0万股 | +24.2万股+6.87% | 加仓 |
| Affinity Asset Advisors, LLC |
| 6% | 4.01% | #7 | $1.33亿 | 375.0万股 | $7,756.0万 | 280.0万股 | +95.0万股+33.93% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| 0.02% | 0.01% | #198 | $1.31亿 | 371.6万股 | $9,577.1万 | 345.7万股 | +25.8万股+7.47% | 加仓 |
| 百达资产管理Pictet Asset Management Holding SA |
| 0.12% | 0.08% | #75 | $1.23亿 | 346.8万股 | $7,404.9万 | 267.3万股 | +79.5万股+29.74% | 加仓 |
| Qube研究科技Qube Research & Technologies Ltd |
| 0.11% | 0.11% | #78 | $1.22亿 | 345.4万股 | $9,559.0万 | 345.1万股 | +3,592股+0.10% | 加仓 |
| 木星资产管理Jupiter Topco LLC |
| 0.05% | — | #134 | $1.12亿 | 316.0万股 | $0 | 0股 | +316.0万股 | 新买入 |
| ADAR1 Capital Management, LLC |
| 5.15% | 5.36% | #9 | $1.12亿 | 315.7万股 | $9,102.0万 | 328.6万股 | -12.9万股-3.92% | 减仓 |
| 宏利人寿MANUFACTURERS LIFE INSURANCE COMPANY, THE |
| 0.08% | 0.02% | #92 | $1.06亿 | 298.8万股 | $1,936.6万 | 69.9万股 | +228.9万股+327.40% | 加仓 |
| D.E.肖D. E. Shaw & Co., Inc. |
| 0.05% | 0.02% | #126 | $1.05亿 | 297.3万股 | $3,857.9万 | 139.3万股 | +158.0万股+113.44% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| 0.02% | 0.02% | #174 | $1.03亿 | 290.1万股 | $7,786.8万 | 281.1万股 | +8.9万股+3.18% | 加仓 |
| Maverick资本MAVERICK CAPITAL LTD |
| 0.88% | 0.52% | #26 | $1.00亿 | 282.9万股 | $4,506.6万 | 162.7万股 | +120.2万股+73.89% | 加仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| 0.02% | 0.01% | #215 | $9,874.8万 | 279.0万股 | $7,578.2万 | 273.6万股 | +5.4万股+1.99% | 加仓 |
| 加拿大国家银行NATIONAL BANK OF CANADA /FI/ |
| 0.09% | 0.18% | #91 | $9,816.8万 | 277.4万股 | $1.74亿 | 629.8万股 | -352.4万股-55.96% | 减仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| 0.02% | <0.01% | #213 | $9,512.4万 | 268.8万股 | $2,668.3万 | 96.3万股 | +172.5万股+179.03% | 加仓 |
| 韦斯资产管理Weiss Asset Management LP |
| 0.94% | — | #24 | $8,998.4万 | 254.3万股 | $0 | 0股 | +254.3万股 | 新买入 |
| Woodline合伙人Woodline Partners LP |
| 0.27% | 0.18% | #51 | $8,849.9万 | 250.1万股 | $4,847.5万 | 175.0万股 | +75.1万股+42.89% | 加仓 |
| HRT金融HRT FINANCIAL LP |
| 0.16% | — | #67 | $8,716.6万 | 246.3万股 | $0 | 0股 | +246.3万股 | 新买入 |
| 花旗集团CITIGROUP INC |
| 0.03% | 0.02% | #161 | $8,066.1万 | 227.9万股 | $4,404.6万 | 159.0万股 | +68.9万股+43.34% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| 0.01% | <0.01% | #269 | $7,827.6万 | 221.2万股 | $2,337.9万 | 84.4万股 | +136.8万股+162.06% | 加仓 |
