| 富达投资FMR LLC |
| 0.21% | 0.19% | #71 | $48.54亿 | 523.1万股 | $36.45亿 | 499.1万股 | +24.0万股+4.82% | 加仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.25% | 0.28% | #61 | $24.85亿 | 267.8万股 | $24.65亿 | 337.5万股 | -69.7万股-20.65% | 减仓 |
| 木星资产管理Jupiter Topco LLC |
| 0.94% | — | #25 | $22.96亿 | 247.4万股 | $0 | 0股 | +247.4万股 | 新买入 |
| 资本世界投资者Capital World Investors |
| 0.24% | 0.22% | #64 | $20.41亿 | 220.0万股 | $16.47亿 | 225.6万股 | -5.6万股-2.50% | 减仓 |
| 工匠合伙人Artisan Partners Limited Partnership |
| 2.22% | 1.72% | #13 | $14.00亿 | 150.9万股 | $10.72亿 | 146.8万股 | +4.1万股+2.78% | 加仓 |
| Avoro资本顾问Avoro Capital Advisors LLC |
| 8.33% | 7.18% | #3 | $9.28亿 | 100.0万股 | $7.30亿 | 100.0万股 | 00.00% | 持仓不变 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| 0.15% | 0.14% | #88 | $8.63亿 | 93.1万股 | $7.46亿 | 102.1万股 | -9.1万股-8.90% | 减仓 |
| 贝莱德BlackRock, Inc. |
| 0.01% | 0.01% | #266 | $7.21亿 | 77.7万股 | $5.90亿 | 80.8万股 | -3.1万股-3.85% | 减仓 |
| RTW投资RTW INVESTMENTS, LP |
| 5.62% | 5.16% | #5 | $6.58亿 | 70.9万股 | $5.18亿 | 70.9万股 | 00.00% | 持仓不变 |
| 摩根士丹利MORGAN STANLEY |
| 0.03% | 0.02% | #181 | $5.97亿 | 64.3万股 | $3.21亿 | 43.5万股 | +20.8万股+47.81% | 加仓 |
| 景顺Invesco Ltd. |
| 0.03% | 0.06% | #180 | $4.12亿 | 44.4万股 | $4.34亿 | 59.5万股 | -15.1万股-25.34% | 减仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| 0.02% | 0.02% | #202 | $3.71亿 | 40.0万股 | $2.92亿 | 40.0万股 | +117股+0.03% | 加仓 |
| 联博ALLIANCEBERNSTEIN L.P. |
| 0.1% | 0.11% | #114 | $2.89亿 | 39.6万股 | $3.55亿 | 42.2万股 | -2.7万股-6.31% | 减仓 |
| Bellevue 集团Bellevue Group AG |
| 5.88% | 5.44% | #4 | $2.79亿 | 30.1万股 | $2.29亿 | 31.3万股 | -1.2万股-3.83% | 减仓 |
| Sands资本管理SANDS CAPITAL MANAGEMENT, LLC |
| 1.03% | 0.97% | #23 | $2.77亿 | 29.9万股 | $2.48亿 | 34.0万股 | -4.2万股-12.25% | 减仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| 0.03% | 0.03% | #192 | $2.54亿 | 27.3万股 | $2.12亿 | 29.0万股 | -1.7万股-5.83% | 减仓 |
| BESSEMER GROUP INC |
| 0.34% | 0.07% | #47 | $2.48亿 | 26.8万股 | $4,692.0万 | 6.4万股 | +20.4万股+316.77% | 加仓 |
| 威廉·布莱尔投资管理WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC |
| 0.74% | 0.64% | #32 | $2.45亿 | 26.5万股 | $1.94亿 | 26.6万股 | -1,450股-0.54% | 减仓 |
| SEI投资SEI INVESTMENTS CO |
| 0.21% | 0.19% | #73 | $2.37亿 | 25.5万股 | $2.10亿 | 28.7万股 | -3.2万股-11.11% | 减仓 |
| 清水投资Clearbridge Investments, LLC |
| 0.19% | 0.15% | #77 | $2.35亿 | 25.4万股 | $1.69亿 | 23.1万股 | +2.2万股+9.69% | 加仓 |
| 詹尼森联营JENNISON ASSOCIATES LLC |
| 0.13% | 0.12% | #95 | $2.10亿 | 22.6万股 | $1.73亿 | 23.7万股 | -1.1万股-4.75% | 减仓 |
| 富兰克林资源FRANKLIN RESOURCES INC |
| 0.04% | 0.04% | #166 | $2.09亿 | 22.5万股 | $1.71亿 | 23.3万股 | -8,563股-3.67% | 减仓 |
| 百达资产管理Pictet Asset Management Holding SA |
| 0.18% | 0.11% | #81 | $1.84亿 | 19.8万股 | $1.08亿 | 14.8万股 | +5.0万股+33.70% | 加仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| 0.13% | 0.06% | #96 | $1.73亿 | 18.6万股 | $7,968.6万 | 10.9万股 | +7.7万股+70.67% | 加仓 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| 0.03% | 0.04% | #177 | $1.68亿 | 18.1万股 | $1.58亿 | 21.6万股 | -3.4万股-15.95% | 减仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| 0.01% | 0.02% | #239 | $1.65亿 | 17.8万股 | $1.69亿 | 23.2万股 | -5.4万股-23.34% | 减仓 |
| 英国法通集团Legal & General Group Plc |
| 0.03% | 0.03% | #175 | $1.64亿 | 17.7万股 | $1.10亿 | 15.1万股 | +2.6万股+17.44% | 加仓 |
| 美国世纪投资AMERICAN CENTURY COMPANIES INC |
| 0.07% | 0.07% | #139 | $1.61亿 | 17.3万股 | $1.27亿 | 17.4万股 | -507股-0.29% | 减仓 |
| Allspring环球投资Allspring Global Investments Holdings, LLC |
| 0.24% | 0.22% | #65 | $1.55亿 | 17.1万股 | $1.30亿 | 17.5万股 | -4,482股-2.56% | 减仓 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| 0.07% | 0.06% | #140 | $1.47亿 | 15.8万股 | $1.30亿 | 17.8万股 | -2.0万股-11.18% | 减仓 |
| 1832资产管理1832 Asset Management L.P. |
| 0.07% | 0.06% | #137 | $1.47亿 | 15.8万股 | $6,148.7万 | 8.4万股 | +7.4万股+87.58% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| 0.01% | 0.02% | #262 | $1.45亿 | 15.7万股 | $1.75亿 | 23.9万股 | -8.3万股-34.48% | 减仓 |
| DEUTSCHE 银行 AG\DEUTSCHE BANK AG\ |
| 0.04% | 0.03% | #171 | $1.27亿 | 13.7万股 | $1.02亿 | 13.9万股 | -2,046股-1.47% | 减仓 |
| BAMCO(巴伦基金)BAMCO INC /NY/ |
| 0.19% | 0.31% | #78 | $1.27亿 | 13.7万股 | $1.01亿 | 13.9万股 | -1,994股-1.44% | 减仓 |
| 巴克莱BARCLAYS PLC |
| 0.02% | <0.01% | #203 | $1.25亿 | 13.4万股 | $401.6万 | 5,500股 | +12.9万股+2,344.13% | 加仓 |
| 拉扎德资产管理LAZARD ASSET MANAGEMENT LLC |
| 0.17% | 0.16% | #82 | $1.22亿 | 13.2万股 | $9,737.7万 | 13.3万股 | -1,351股-1.01% | 减仓 |
| Checkpoint Capital L.P. |
| 31.25% | 40.1% | #1 | $1.22亿 | 13.1万股 | $1.12亿 | 15.3万股 | -2.2万股-14.19% | 减仓 |
| 暮色资产管理EVENTIDE ASSET MANAGEMENT, LLC |
| 1.56% | 1.52% | #18 | $1.17亿 | 12.6万股 | $9,173.6万 | 12.6万股 | +11股+0.01% | 加仓 |
| AGF管理AGF MANAGEMENT LTD |
| 0.45% | 0.41% | #40 | $1.16亿 | 12.5万股 | $9,133.2万 | 12.5万股 | +412股+0.33% | 加仓 |
| 法国巴黎银行资产管理BNP Paribas Asset Management Holding S.A. |
| 0.11% | — | #104 | $1.13亿 | 12.2万股 | $0 | 0股 | +12.2万股 | 新买入 |
| LORD, ABBETT & CO. LLC |
| 0.29% | 0.36% | #52 | $1.00亿 | 10.8万股 | $1.11亿 | 15.2万股 | -4.4万股-28.82% | 减仓 |
| 第一信托顾问FIRST TRUST ADVISORS LP |
| 0.06% | 0.06% | #153 | $9,411.3万 | 10.1万股 | $7,827.9万 | 10.7万股 | -5,755股-5.37% | 减仓 |
| PGGM Investments |
| 2.19% | 0.92% | #14 | $8,954.0万 | 9.7万股 | $5,222.3万 | 7.2万股 | +2.5万股+34.95% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| 0.03% | 0.02% | #190 | $8,758.2万 | 9.4万股 | $5,284.5万 | 7.2万股 | +2.2万股+30.45% | 加仓 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 1.63% | 1.98% | #17 | $8,617.1万 | 9.3万股 | $9,997.1万 | 13.7万股 | -4.4万股-32.15% | 减仓 |
| Fiera资本Fiera Capital Corp |
| 0.3% | 0.54% | #50 | $8,389.2万 | 9.0万股 | $1.59亿 | 21.7万股 | -12.7万股-58.37% | 减仓 |
| 资本研究全球投资者Capital Research Global Investors |
| 0.01% | — | #261 | $8,211.8万 | 8.9万股 | $0 | 0股 | +8.9万股 | 新买入 |
| Federated HermesFEDERATED HERMES, INC. |
| 0.12% | 0.11% | #101 | $8,098.3万 | 8.7万股 | $6,955.9万 | 9.5万股 | -7,965股-8.36% | 减仓 |
| PineBridge投资PINEBRIDGE INVESTMENTS LLC |
| 0.67% | 0.64% | #33 | $8,076.2万 | 8.7万股 | $7,580.9万 | 10.4万股 | -1.7万股-16.15% | 减仓 |
| 加拿大公共部门养老金投资委员会(PSP)PUBLIC SECTOR PENSION INVESTMENT BOARD |
| 0.2% | 0.17% | #74 | $7,821.1万 | 8.4万股 | $5,352.7万 | 7.3万股 | +1.1万股+15.01% | 加仓 |
