| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #28 | $4,418.4万 | 946.1万股 | $1.3万 | 3,728股 | +945.8万股+253,689.67% | 加仓 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #31 | $3,886.2万 | 832.2万股 | $3,346.7万 | 810.3万股 | +21.8万股+2.69% | 加仓 |
| Bain Capital Life Sciences Investors, LLC |
| 2.21% | 2.97% | #6 | $3,720.8万 | 796.7万股 | $3,290.6万 | 796.7万股 | 00.00% | 持仓不变 |
| 洞察顾问PERCEPTIVE ADVISORS LLC |
| 0.56% | 0.54% | #10 | $3,704.9万 | 793.3万股 | $2,782.6万 | 673.8万股 | +119.6万股+17.75% | 加仓 |
| Saturn V Capital Management LP |
| 4.67% | 4.83% | #3 | $3,256.6万 | 697.3万股 | $2,666.6万 | 645.7万股 | +51.7万股+8.00% | 加仓 |
| Empery Asset Management, LP |
| 37.43% | 44.5% | #1 | $3,236.6万 | 693.1万股 | $3,693.9万 | 894.4万股 | -201.4万股-22.51% | 减仓 |
| 深轨资本Deep Track Capital, LP |
| 0.4% | 0.43% | #13 | $2,745.4万 | 587.9万股 | $2,618.2万 | 634.0万股 | -46.1万股-7.27% | 减仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #41 | $2,594.1万 | 555.5万股 | $500.5万 | 121.2万股 | +434.3万股+358.40% | 加仓 |
| Kalehua Capital Management LLC |
| 12.46% | 10.88% | #2 | $1,738.6万 | 372.3万股 | $1,537.5万 | 372.3万股 | 00.00% | 持仓不变 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #43 | $1,735.3万 | 371.6万股 | $1,444.5万 | 349.8万股 | +21.8万股+6.24% | 加仓 |
| NEA Management Company, LLC |
| 0.95% | 0.76% | #9 | $1,510.2万 | 323.4万股 | $1,335.5万 | 323.4万股 | 00.00% | 持仓不变 |
| Rosalind Advisors, Inc. |
| 3.56% | 5.33% | #5 | $1,501.3万 | 321.5万股 | $1,327.7万 | 321.5万股 | 00.00% | 持仓不变 |
| BRAIDWELL LP |
| 0.5% | 0.45% | #12 | $1,364.9万 | 292.3万股 | $1,351.7万 | 327.3万股 | -35.0万股-10.70% | 减仓 |
| 黑石集团Blackstone Inc. |
| 0.04% | 0.04% | #19 | $1,252.5万 | 268.2万股 | $1,107.6万 | 268.2万股 | 00.00% | 持仓不变 |
| Trails Edge Capital Partners, LP |
| 1.91% | 2.43% | #7 | $1,200.9万 | 257.1万股 | $1,062.0万 | 257.1万股 | 00.00% | 持仓不变 |
| Nantahala 资本管理Nantahala Capital Management, LLC |
| 0.38% | 0.37% | #14 | $1,143.9万 | 244.9万股 | $1,011.6万 | 244.9万股 | 00.00% | 持仓不变 |
| BVF INC/IL |
| 0.27% | 0.29% | #16 | $1,043.2万 | 223.4万股 | $922.5万 | 223.4万股 | 00.00% | 持仓不变 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #39 | $980.1万 | 209.8万股 | $388.3万 | 94.0万股 | +115.8万股+123.26% | 加仓 |
| Venrock Adviser, LLC |
| 0.27% | 0.05% | #15 | $903.3万 | 193.4万股 | $136.5万 | 33.1万股 | +160.4万股+485.21% | 加仓 |
| Samsara BioCapital, LLC |
| 0.54% | 0.74% | #11 | $651.7万 | 139.6万股 | $756.8万 | 183.3万股 | -43.7万股-23.85% | 减仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #49 | $605.2万 | 129.6万股 | $166.7万 | 40.4万股 | +89.2万股+221.17% | 加仓 |
| Woodline合伙人Woodline Partners LP |
| 0.01% | 0.02% | #22 | $467.5万 | 100.1万股 | $413.5万 | 100.1万股 | 00.00% | 持仓不变 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #42 | $428.0万 | 91.7万股 | $364.3万 | 88.2万股 | +3.4万股+3.90% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #44 | $304.9万 | 65.3万股 | $73.6万 | 17.8万股 | +47.5万股+266.29% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #38 | $267.1万 | 57.2万股 | $198.5万 | 48.1万股 | +9.1万股+18.99% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #56 | $253.2万 | 54.2万股 | $0 | 0股 | +54.2万股 | 新买入 |
| Verdad Advisers, LP |
| 1.57% | — | #8 | $164.4万 | 35.2万股 | $0 | 0股 | +35.2万股 | 新买入 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #60 | $123.5万 | 26.4万股 | $353.6万 | 85.6万股 | -59.2万股-69.13% | 减仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #50 | $122.9万 | 26.3万股 | $27.6万 | 6.7万股 | +19.7万股+294.41% | 加仓 |
| Caption管理Caption Management, LLC |
| 0.01% | — | #26 | $116.8万 | 25.0万股 | $0 | 0股 | +25.0万股 | 新买入 |
| Stonepine Capital Management, LLC |
| 0.16% | 0.55% | #17 | $105.1万 | 22.5万股 | $138.5万 | 33.5万股 | -11.0万股-32.90% | 减仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | — | #52 | $91.7万 | 19.6万股 | $0 | 0股 | +19.6万股 | 新买入 |
| Affinity Asset Advisors, LLC |
| 0.03% | 0.03% | #20 | $67.7万 | 14.5万股 | $59.9万 | 14.5万股 | 00.00% | 持仓不变 |
| 纽文Nuveen, LLC |
| <0.01% | — | #54 | $50.2万 | 10.7万股 | $0 | 0股 | +10.7万股 | 新买入 |
| 景顺Invesco Ltd. |
| <0.01% | <0.01% | #72 | $45.2万 | 9.7万股 | $8.2万 | 2.0万股 | +7.7万股+384.64% | 加仓 |
| ALPS顾问ALPS ADVISORS INC |
| <0.01% | — | #30 | $44.7万 | 9.6万股 | $0 | 0股 | +9.6万股 | 新买入 |
| RhumbLine顾问RHUMBLINE ADVISERS |
| <0.01% | — | #46 | $44.4万 | 9.5万股 | $0 | 0股 | +9.5万股 | 新买入 |
| 萨斯奎汉纳组合策略Susquehanna Portfolio Strategies, LLC |
| 0.01% | 0.01% | #25 | $40.8万 | 8.7万股 | $42.4万 | 10.3万股 | -1.5万股-14.93% | 减仓 |
| DEUTSCHE 银行 AG\DEUTSCHE BANK AG\ |
| <0.01% | — | #58 | $36.8万 | 7.9万股 | $0 | 0股 | +7.9万股 | 新买入 |
| GSA CAPITAL PARTNERS LLP |
| 0.02% | — | #21 | $35.6万 | 7.6万股 | $0 | 0股 | +7.6万股 | 新买入 |
| 美国世纪投资AMERICAN CENTURY COMPANIES INC |
| <0.01% | — | #51 | $34.9万 | 7.5万股 | $0 | 0股 | +7.5万股 | 新买入 |
| 花旗集团CITIGROUP INC |
| <0.01% | <0.01% | #57 | $32.7万 | 7.0万股 | $14.8万 | 3.6万股 | +3.4万股+96.04% | 加仓 |
| 富国银行WELLS FARGO & COMPANY/MN |
| <0.01% | — | #68 | $31.6万 | 6.8万股 | $0 | 0股 | +6.8万股 | 新买入 |
| Palumbo Wealth Management LLC |
| 0.07% | 0.13% | #18 | $31.3万 | 6.7万股 | $54.1万 | 13.1万股 | -6.4万股-48.77% | 减仓 |
| SquarepointSquarepoint Ops LLC |
| <0.01% | — | #45 | $31.3万 | 6.7万股 | $0 | 0股 | +6.7万股 | 新买入 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | — | #74 | $31.0万 | 6.6万股 | $0 | 0股 | +6.6万股 | 新买入 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #73 | $27.1万 | 5.8万股 | $110.4万 | 26.7万股 | -20.9万股-78.29% | 减仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | — | #69 | $24.2万 | 5.2万股 | $0 | 0股 | +5.2万股 | 新买入 |
| 大都会人寿投资管理MetLife Investment Management, LLC |
| <0.01% | — | #33 | $22.4万 | 4.8万股 | $0 | 0股 | +4.8万股 | 新买入 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #79 | $21.9万 | 4.7万股 | $62.2万 | 15.1万股 | -10.4万股-68.90% | 减仓 |
