| Rosalind Advisors, Inc. |
| 9.84% | 12.31% | #1 | $4,155.2万 | 330.0万股 | $3,062.8万 | 330.0万股 | 00.00% | 持仓不变 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #51 | $3,407.9万 | 270.7万股 | $1,656.0万 | 178.4万股 | +92.2万股+51.69% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #65 | $1,537.6万 | 122.1万股 | $1,233.6万 | 132.9万股 | -10.8万股-8.13% | 减仓 |
| Propel Bio Management, LLC |
| 5.74% | 5.77% | #2 | $1,097.2万 | 87.1万股 | $915.9万 | 98.0万股 | -10.8万股-11.05% | 减仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #52 | $923.3万 | 73.3万股 | $642.4万 | 69.2万股 | +4.1万股+5.94% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #72 | $855.2万 | 67.9万股 | $616.6万 | 66.4万股 | +1.5万股+2.24% | 加仓 |
| Algert全球ALGERT GLOBAL LLC |
| 0.09% | 0.02% | #13 | $731.1万 | 58.1万股 | $135.2万 | 14.6万股 | +43.5万股+298.47% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #37 | $713.1万 | 56.6万股 | $545.7万 | 58.8万股 | -2.2万股-3.69% | 减仓 |
| Divisadero Street 资本管理Divisadero Street Capital Management, LP |
| 0.14% | 0.19% | #8 | $629.2万 | 50.0万股 | $463.8万 | 50.0万股 | 00.00% | 持仓不变 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #70 | $513.7万 | 40.8万股 | $272.0万 | 25.3万股 | +15.5万股+61.25% | 加仓 |
| ExodusPoint资本ExodusPoint Capital Management, LP |
| 0.03% | — | #23 | $453.1万 | 36.0万股 | $0 | 0股 | +36.0万股 | 新买入 |
| Caption管理Caption Management, LLC |
| 0.02% | 0.02% | #24 | $413.2万 | 32.8万股 | $304.6万 | 32.8万股 | 00.00% | 持仓不变 |
| Private Wealth Advisors, LLC |
| 1.02% | 1.54% | #4 | $397.7万 | 31.6万股 | $548.9万 | 59.2万股 | -27.6万股-46.60% | 减仓 |
| 简化资产管理Simplify Asset Management Inc. |
| 0.05% | 0.04% | #17 | $333.3万 | 26.5万股 | $242.3万 | 26.1万股 | +3,644股+1.40% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #57 | $317.4万 | 25.2万股 | $233.7万 | 25.2万股 | +245股+0.10% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #69 | $315.1万 | 25.0万股 | $268.3万 | 28.9万股 | -3.9万股-13.43% | 减仓 |
| ADAR1 Capital Management, LLC |
| 0.13% | 0.12% | #10 | $282.5万 | 22.4万股 | $208.2万 | 22.4万股 | 00.00% | 持仓不变 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| <0.01% | <0.01% | #38 | $275.7万 | 21.9万股 | $177.8万 | 19.2万股 | +2.7万股+14.26% | 加仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | — | #53 | $264.8万 | 21.0万股 | $0 | 0股 | +21.0万股 | 新买入 |
| 肯尼迪资本管理KENNEDY CAPITAL MANAGEMENT LLC |
| 0.05% | 0.04% | #18 | $257.0万 | 20.4万股 | $193.0万 | 20.8万股 | -3,780股-1.82% | 减仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #87 | $243.6万 | 19.3万股 | $165.2万 | 17.8万股 | +1.5万股+8.66% | 加仓 |
| Ikarian Capital, LLC |
| 0.25% | 0.32% | #5 | $233.8万 | 18.6万股 | $400.2万 | 43.1万股 | -24.6万股-56.95% | 减仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #50 | $229.0万 | 18.2万股 | $187.3万 | 20.2万股 | -2.0万股-9.87% | 减仓 |
| 纽文Nuveen, LLC |
| <0.01% | <0.01% | #49 | $228.6万 | 18.2万股 | $96.3万 | 10.4万股 | +7.8万股+74.99% | 加仓 |
| AQR资本管理AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #46 | $217.8万 | 17.3万股 | $29.8万 | 3.2万股 | +14.1万股+438.99% | 加仓 |
| CIBC世界市场CIBC WORLD MARKET INC. |
| <0.01% | <0.01% | #34 | $205.5万 | 16.3万股 | $176.1万 | 19.0万股 | -2.7万股-13.98% | 减仓 |
| Lane Generational LLC |
| 1.65% | 1.52% | #3 | $188.4万 | 15.0万股 | $190.3万 | 20.5万股 | -5.5万股-27.03% | 减仓 |
| 汇丰控股HSBC HOLDINGS PLC |
| <0.01% | — | #47 | $170.6万 | 13.6万股 | $0 | 0股 | +13.6万股 | 新买入 |
| 英仕曼集团Man Group plc |
| <0.01% | <0.01% | #35 | $161.8万 | 12.8万股 | $94.9万 | 10.2万股 | +2.6万股+25.71% | 加仓 |
| Diametric Capital, LP |
| 0.16% | 0.38% | #6 | $154.7万 | 12.3万股 | $145.2万 | 15.6万股 | -3.4万股-21.50% | 减仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #78 | $136.2万 | 10.8万股 | $91.5万 | 9.9万股 | +9,523股+9.65% | 加仓 |
| 巴克莱BARCLAYS PLC |
| <0.01% | <0.01% | #71 | $135.9万 | 10.8万股 | $35.1万 | 3.8万股 | +7.0万股+185.21% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #90 | $121.1万 | 9.6万股 | $71.6万 | 7.7万股 | +1.9万股+24.68% | 加仓 |
| Capital Advisors Wealth Management, LLC |
| 0.14% | 0.12% | #9 | $117.1万 | 9.3万股 | $86.3万 | 9.3万股 | 00.00% | 持仓不变 |
| 跳跃金融Jump Financial, LLC |
| 0.01% | — | #30 | $110.8万 | 8.8万股 | $0 | 0股 | +8.8万股 | 新买入 |
| GSA CAPITAL PARTNERS LLP |
| 0.07% | 0.01% | #16 | $108.2万 | 8.6万股 | $14.9万 | 1.6万股 | +7.0万股+434.98% | 加仓 |
| 杰富瑞金融集团Jefferies Financial Group Inc. |
| 0.01% | 0.01% | #32 | $105.7万 | 8.4万股 | $77.9万 | 8.4万股 | 00.00% | 持仓不变 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #85 | $105.1万 | 8.3万股 | $73.0万 | 7.9万股 | +4,840股+6.16% | 加仓 |
| Stonepine Capital Management, LLC |
| 0.15% | 0.37% | #7 | $100.0万 | 10.0万股 | $92.8万 | 10.0万股 | 00.00% | 持仓不变 |
| 罗素投资集团Russell Investments Group, Ltd. |
| <0.01% | <0.01% | #48 | $85.2万 | 6.8万股 | $2.4万 | 2,604股 | +6.5万股+2,498.23% | 加仓 |
| FOX RUN MANAGEMENT, L.L.C. |
| 0.13% | — | #11 | $77.7万 | 6.2万股 | $0 | 0股 | +6.2万股 | 新买入 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #102 | $77.5万 | 6.2万股 | $53.6万 | 5.8万股 | +3,795股+6.57% | 加仓 |
| Quantbot Technologies LP |
| 0.03% | <0.01% | #22 | $75.0万 | 6.0万股 | $8.6万 | 9,301股 | +5.0万股+540.36% | 加仓 |
| D.E.肖D. E. Shaw & Co., Inc. |
| <0.01% | — | #60 | $72.9万 | 5.8万股 | $0 | 0股 | +5.8万股 | 新买入 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #92 | $72.7万 | 5.8万股 | $167.7万 | 18.1万股 | -12.3万股-68.06% | 减仓 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #59 | $72.6万 | 5.8万股 | $12.1万 | 1.3万股 | +4.5万股+342.88% | 加仓 |
| Creative Planning财富管理Creative Planning |
| <0.01% | <0.01% | #58 | $61.0万 | 4.8万股 | $36.7万 | 4.0万股 | +8,885股+22.47% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #97 | $52.5万 | 4.2万股 | $64.2万 | 6.9万股 | -2.7万股-39.67% | 减仓 |
| Pale Fire Capital SE |
| 0.04% | 0.03% | #20 | $50.5万 | 4.0万股 | $37.2万 | 4.0万股 | 00.00% | 持仓不变 |
| RhumbLine顾问RHUMBLINE ADVISERS |
| <0.01% | <0.01% | #61 | $45.9万 | 3.6万股 | $31.9万 | 3.4万股 | +2,110股+6.15% | 加仓 |
