| RA资本管理RA CAPITAL MANAGEMENT, L.P. |
| 0.27% | 0.24% | #8 | $3,057.9万 | 1,080.5万股 | $2,279.9万 | 1,080.5万股 | 00.00% | 持仓不变 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #59 | $1,783.0万 | 630.0万股 | $951.3万 | 450.8万股 | +179.2万股+39.74% | 加仓 |
| NEA Management Company, LLC |
| 0.64% | 0.43% | #5 | $1,010.0万 | 356.9万股 | $753.0万 | 356.9万股 | 00.00% | 持仓不变 |
| Samsara BioCapital, LLC |
| 0.82% | 0.72% | #4 | $992.7万 | 350.8万股 | $740.1万 | 350.8万股 | 00.00% | 持仓不变 |
| SR ONE CAPITAL MANAGEMENT, LP |
| 0.91% | 0.77% | #3 | $943.3万 | 333.3万股 | $703.3万 | 333.3万股 | 00.00% | 持仓不变 |
| GSK plc |
| 1.48% | 1.11% | #1 | $891.7万 | 315.1万股 | $664.8万 | 315.1万股 | 00.00% | 持仓不变 |
| Monaco Asset Management SAM |
| 0.53% | 0.98% | #6 | $671.7万 | 237.3万股 | $532.1万 | 252.2万股 | -14.9万股-5.89% | 减仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #41 | $638.4万 | 225.6万股 | $380.9万 | 180.5万股 | +45.1万股+24.97% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #73 | $630.1万 | 222.6万股 | $424.4万 | 201.1万股 | +21.5万股+10.69% | 加仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #27 | $530.1万 | 187.3万股 | $432.0万 | 204.7万股 | -17.4万股-8.50% | 减仓 |
| Wasatch顾问WASATCH ADVISORS LP |
| 0.03% | 0.02% | #15 | $446.5万 | 157.8万股 | $332.9万 | 157.8万股 | 00.00% | 持仓不变 |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | <0.01% | #26 | $385.0万 | 136.1万股 | $265.5万 | 126.0万股 | +10.1万股+8.00% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #78 | $364.0万 | 128.6万股 | $261.1万 | 123.7万股 | +4.9万股+3.93% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #69 | $363.9万 | 128.6万股 | $267.6万 | 126.8万股 | +1.8万股+1.39% | 加仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | 0.01% | #25 | $333.3万 | 117.8万股 | $365.5万 | 173.2万股 | -55.5万股-32.02% | 减仓 |
| AQR资本管理AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #34 | $298.4万 | 105.4万股 | $125.7万 | 59.6万股 | +45.9万股+76.97% | 加仓 |
| AWM Investment Company, Inc. |
| 0.22% | 0.21% | #9 | $256.4万 | 90.6万股 | $191.2万 | 90.6万股 | 00.00% | 持仓不变 |
| 黑石集团Blackstone Inc. |
| 0.01% | — | #21 | $211.4万 | 74.7万股 | $0 | 0股 | +74.7万股 | 新买入 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| <0.01% | — | #31 | $190.5万 | 67.3万股 | $0 | 0股 | +67.3万股 | 新买入 |
| PanAgora资产管理PANAGORA ASSET MANAGEMENT INC |
| 0.01% | <0.01% | #24 | $165.1万 | 58.3万股 | $60.0万 | 28.4万股 | +29.9万股+105.22% | 加仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #82 | $160.4万 | 56.3万股 | $115.0万 | 57.5万股 | -1.2万股-2.09% | 减仓 |
| Peapod Lane Capital LLC |
| 1.05% | 1.15% | #2 | $155.6万 | 55.0万股 | $140.7万 | 67.6万股 | -12.6万股-18.68% | 减仓 |
| Alyeska投资集团Alyeska Investment Group, L.P. |
| <0.01% | 0.01% | #28 | $137.2万 | 48.5万股 | $439.9万 | 208.5万股 | -160.0万股-76.74% | 减仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #60 | $136.8万 | 48.3万股 | $73.1万 | 34.7万股 | +13.7万股+39.42% | 加仓 |
| 纽文Nuveen, LLC |
| <0.01% | <0.01% | #53 | $132.9万 | 47.0万股 | $94.1万 | 44.6万股 | +2.4万股+5.33% | 加仓 |
| 普信投资管理T. Rowe Price Investment Management, Inc. |
| <0.01% | — | #37 | $128.8万 | 45.5万股 | $0 | 0股 | +45.5万股 | 新买入 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #79 | $122.8万 | 43.4万股 | $81.2万 | 38.5万股 | +4.9万股+12.72% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #75 | $105.1万 | 37.1万股 | $88.0万 | 41.7万股 | -4.6万股-10.97% | 减仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #68 | $98.5万 | 34.8万股 | $69.2万 | 32.8万股 | +2.0万股+6.14% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #55 | $91.6万 | 32.4万股 | $30.7万 | 14.6万股 | +17.8万股+122.16% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #98 | $85.4万 | 30.2万股 | $57.4万 | 27.2万股 | +3.0万股+10.97% | 加仓 |
| XTX资本XTX Topco Ltd |
| 0.01% | 0.01% | #19 | $82.1万 | 29.0万股 | $32.5万 | 15.4万股 | +13.6万股+88.53% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #96 | $74.6万 | 26.4万股 | $98.0万 | 47.3万股 | -20.9万股-44.26% | 减仓 |
| 景顺Invesco Ltd. |
| <0.01% | <0.01% | #92 | $58.7万 | 20.7万股 | $31.8万 | 15.1万股 | +5.6万股+37.35% | 加仓 |
| IEQ资本IEQ CAPITAL, LLC |
| <0.01% | <0.01% | #29 | $50.1万 | 17.7万股 | $21.7万 | 10.3万股 | +7.4万股+72.13% | 加仓 |
| D.E.肖D. E. Shaw & Co., Inc. |
| <0.01% | <0.01% | #67 | $46.0万 | 16.3万股 | $75.3万 | 35.7万股 | -19.4万股-54.47% | 减仓 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #103 | $37.2万 | 13.2万股 | $29.9万 | 14.2万股 | -1.0万股-7.24% | 减仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #91 | $37.1万 | 13.1万股 | $27.6万 | 13.1万股 | 00.00% | 持仓不变 |
| NANO CAP NEW MILLENNIUM GROWTH FUND L P |
| 0.28% | 0.35% | #7 | $36.8万 | 13.0万股 | $36.9万 | 17.5万股 | -4.5万股-25.71% | 减仓 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #115 | $36.8万 | 13.0万股 | $27.2万 | 12.9万股 | +843股+0.65% | 加仓 |
| 萨斯奎汉纳组合策略Susquehanna Portfolio Strategies, LLC |
| 0.01% | <0.01% | #23 | $35.8万 | 12.6万股 | $13.1万 | 6.2万股 | +6.4万股+103.99% | 加仓 |
| 桥道资本管理BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| 0.01% | <0.01% | #22 | $34.8万 | 12.3万股 | $22.7万 | 10.8万股 | +1.5万股+13.91% | 加仓 |
| 巴克莱BARCLAYS PLC |
| <0.01% | <0.01% | #87 | $34.4万 | 12.2万股 | $26.1万 | 12.3万股 | -1,923股-1.56% | 减仓 |
| Qube研究科技Qube Research & Technologies Ltd |
| <0.01% | — | #52 | $34.2万 | 12.1万股 | $0 | 0股 | +12.1万股 | 新买入 |
| 麦肯齐金融MACKENZIE FINANCIAL CORP |
| <0.01% | — | #54 | $32.6万 | 11.5万股 | $0 | 0股 | +11.5万股 | 新买入 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #90 | $32.5万 | 11.5万股 | $23.2万 | 11.0万股 | +4,829股+4.39% | 加仓 |
| GSA CAPITAL PARTNERS LLP |
| 0.02% | 0.04% | #17 | $32.1万 | 11.3万股 | $60.6万 | 28.7万股 | -17.4万股-60.54% | 减仓 |
| Point72资产管理Point72 Asset Management, L.P. |
| <0.01% | <0.01% | #49 | $30.2万 | 10.7万股 | $12.7万 | 6.0万股 | +4.6万股+76.98% | 加仓 |
| 英仕曼集团Man Group plc |
| <0.01% | <0.01% | #45 | $28.3万 | 10.0万股 | $32.2万 | 15.3万股 | -5.3万股-34.45% | 减仓 |
| 美国世纪投资AMERICAN CENTURY COMPANIES INC |
| <0.01% | <0.01% | #77 | $26.8万 | 9.5万股 | $20.0万 | 9.5万股 | 00.00% | 持仓不变 |
