| RA资本管理RA CAPITAL MANAGEMENT, L.P. |
| 0.58% | 0.27% | #14 | $6,730.5万 | 1,272.3万股 | $2,551.5万 | 680.4万股 | +591.9万股+86.99% | 加仓 |
| BML Capital Management, LLC |
| 36.13% | 34.31% | #1 | $6,334.8万 | 1,197.5万股 | $5,343.8万 | 1,425.0万股 | -227.5万股-15.96% | 减仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #66 | $5,309.6万 | 1,003.7万股 | $2,777.6万 | 740.7万股 | +263.0万股+35.51% | 加仓 |
| 深轨资本Deep Track Capital, LP |
| 0.72% | 0.57% | #13 | $4,943.5万 | 934.5万股 | $3,504.4万 | 934.5万股 | 00.00% | 持仓不变 |
| Vivo Capital, LLC |
| 3.23% | 2.08% | #4 | $3,541.5万 | 669.5万股 | $2,500.0万 | 666.7万股 | +2.8万股+0.42% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #68 | $3,077.7万 | 581.8万股 | $1,937.8万 | 516.7万股 | +65.0万股+12.59% | 加仓 |
| Frazier Life Sciences 管理Frazier Life Sciences Management, L.P. |
| 0.57% | 0.48% | #15 | $2,605.5万 | 492.5万股 | $1,847.0万 | 492.5万股 | 00.00% | 持仓不变 |
| Rock Springs Capital Management LP |
| 1.12% | 0.99% | #8 | $2,290.9万 | 433.1万股 | $1,677.2万 | 447.3万股 | -14.2万股-3.18% | 减仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.03% | 0.02% | #26 | $2,153.6万 | 407.1万股 | $1,451.6万 | 387.1万股 | +20.0万股+5.17% | 加仓 |
| Decheng Capital LLC |
| 2.92% | 2.29% | #5 | $2,138.1万 | 404.2万股 | $1,515.7万 | 404.2万股 | 00.00% | 持仓不变 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #74 | $1,722.1万 | 325.5万股 | $753.3万 | 200.9万股 | +124.7万股+62.06% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #63 | $1,687.9万 | 319.0万股 | $909.2万 | 242.4万股 | +76.6万股+31.62% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #53 | $1,262.8万 | 238.7万股 | $1,056.8万 | 281.8万股 | -43.1万股-15.29% | 减仓 |
| BRAIDWELL LP |
| 0.42% | 0.21% | #17 | $1,133.3万 | 214.2万股 | $637.2万 | 169.9万股 | +44.3万股+26.09% | 加仓 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| 0.01% | 0.02% | #32 | $1,070.4万 | 202.3万股 | $1,260.5万 | 336.1万股 | -133.8万股-39.80% | 减仓 |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 1.07% | — | #9 | $1,029.7万 | 194.6万股 | $0 | 0股 | +194.6万股 | 新买入 |
| Kalehua Capital Management LLC |
| 6.95% | 4.86% | #2 | $969.3万 | 183.2万股 | $687.1万 | 183.2万股 | 00.00% | 持仓不变 |
| Jones Hill Capital LP |
| 1.98% | — | #6 | $930.8万 | 175.9万股 | $0 | 0股 | +175.9万股 | 新买入 |
| ACADIAN ASSET MANAGEMENT LLC |
| 0.01% | 0.01% | #35 | $868.3万 | 164.1万股 | $577.0万 | 154.0万股 | +10.2万股+6.60% | 加仓 |
| Palo Alto Investors LP |
| 1.25% | 0.93% | #7 | $853.5万 | 161.3万股 | $605.0万 | 161.3万股 | 00.00% | 持仓不变 |
| Woodline合伙人Woodline Partners LP |
| 0.03% | 0.02% | #27 | $852.2万 | 161.1万股 | $557.1万 | 148.6万股 | +12.5万股+8.44% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #83 | $775.4万 | 146.6万股 | $621.0万 | 165.6万股 | -19.0万股-11.49% | 减仓 |
| PanAgora资产管理PANAGORA ASSET MANAGEMENT INC |
| 0.02% | 0.01% | #28 | $717.4万 | 135.6万股 | $188.4万 | 50.2万股 | +85.4万股+169.99% | 加仓 |
| Connor Clark & Lunn投资管理Connor, Clark & Lunn Investment Management Ltd. |
| 0.01% | 0.01% | #33 | $640.0万 | 121.0万股 | $531.9万 | 141.8万股 | -20.8万股-14.70% | 减仓 |
| MPM BioImpact LLC |
| 0.34% | 0.11% | #18 | $551.5万 | 104.2万股 | $147.0万 | 39.2万股 | +65.1万股+165.99% | 加仓 |
| DEUTSCHE 银行 AG\DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #49 | $550.7万 | 104.1万股 | $374.2万 | 99.8万股 | +4.3万股+4.32% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #71 | $528.3万 | 99.9万股 | $273.1万 | 72.8万股 | +27.1万股+37.15% | 加仓 |
| Aldebaran Capital, LLC |
| 3.73% | 2.72% | #3 | $495.5万 | 93.7万股 | $355.2万 | 94.7万股 | -1.0万股-1.10% | 减仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #58 | $479.9万 | 90.7万股 | $235.8万 | 62.9万股 | +27.8万股+44.26% | 加仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| 0.01% | <0.01% | #40 | $432.5万 | 81.8万股 | $188.5万 | 50.3万股 | +31.5万股+62.65% | 加仓 |
| Three Bridge Wealth Advisors, LLC |
| 0.95% | 0.74% | #10 | $378.1万 | 71.5万股 | $268.1万 | 71.5万股 | 00.00% | 持仓不变 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #87 | $322.2万 | 60.9万股 | $220.8万 | 58.9万股 | +2.0万股+3.48% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #62 | $277.1万 | 52.4万股 | $283.5万 | 75.6万股 | -23.2万股-30.71% | 减仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #93 | $273.5万 | 51.7万股 | $225.2万 | 60.0万股 | -8.3万股-13.89% | 减仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #77 | $271.4万 | 51.4万股 | $191.4万 | 51.1万股 | +2,379股+0.47% | 加仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #102 | $235.4万 | 46.9万股 | $169.8万 | 48.7万股 | -1.8万股-3.63% | 减仓 |
| Aisling Capital Management LP |
| 0.49% | 0.34% | #16 | $229.8万 | 43.4万股 | $162.9万 | 43.4万股 | 00.00% | 持仓不变 |
| Bollard Group LLC |
| 0.07% | 0.05% | #22 | $228.3万 | 43.2万股 | $161.9万 | 43.2万股 | 00.00% | 持仓不变 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 0.04% | — | #24 | $223.0万 | 42.2万股 | $0 | 0股 | +42.2万股 | 新买入 |
| D.E.肖D. E. Shaw & Co., Inc. |
| <0.01% | <0.01% | #59 | $219.3万 | 41.4万股 | $337.8万 | 90.1万股 | -48.6万股-53.99% | 减仓 |
| Tetragon Partners GP Ltd |
| 0.33% | — | #19 | $211.6万 | 40.0万股 | $0 | 0股 | +40.0万股 | 新买入 |
| 罗素投资集团Russell Investments Group, Ltd. |
| <0.01% | <0.01% | #52 | $193.1万 | 36.5万股 | $115.6万 | 30.8万股 | +5.7万股+18.46% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #90 | $183.1万 | 34.6万股 | $97.9万 | 26.1万股 | +8.5万股+32.59% | 加仓 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #115 | $166.0万 | 31.4万股 | $66.1万 | 17.6万股 | +13.7万股+77.97% | 加仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #89 | $149.5万 | 28.3万股 | $77.6万 | 20.7万股 | +7.6万股+36.51% | 加仓 |
| 纽文Nuveen, LLC |
| <0.01% | <0.01% | #82 | $147.3万 | 27.8万股 | $44.3万 | 11.8万股 | +16.0万股+135.90% | 加仓 |
| 雷蒙德詹姆斯金融RAYMOND JAMES FINANCIAL INC |
| <0.01% | <0.01% | #78 | $145.8万 | 27.6万股 | $99.9万 | 26.6万股 | +9,163股+3.44% | 加仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #91 | $141.5万 | 26.7万股 | $96.4万 | 25.7万股 | +1.0万股+4.02% | 加仓 |
| SUPERSTRING CAPITAL MANAGEMENT LP |
| 0.86% | 0.98% | #12 | $136.3万 | 25.8万股 | $137.4万 | 36.6万股 | -10.9万股-29.69% | 减仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #97 | $136.0万 | 25.7万股 | $77.6万 | 20.7万股 | +5.0万股+24.27% | 加仓 |
