| L1 Capital Pty Ltd |
| 2.58% | 1.7% | #3 | $7,672.2万 | 778.9万股 | $4,322.9万 | 778.9万股 | 00.00% | 持仓不变 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #52 | $6,765.1万 | 686.8万股 | $1,610.2万 | 290.1万股 | +396.7万股+136.72% | 加仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #70 | $5,684.6万 | 577.1万股 | $2,713.5万 | 488.9万股 | +88.2万股+18.04% | 加仓 |
| Sio Capital Management, LLC |
| 9.04% | 4.28% | #1 | $5,462.8万 | 554.6万股 | $2,987.5万 | 538.3万股 | +16.3万股+3.03% | 加仓 |
| 洞察顾问PERCEPTIVE ADVISORS LLC |
| 0.51% | 0.37% | #8 | $3,374.1万 | 342.5万股 | $1,901.1万 | 342.5万股 | 00.00% | 持仓不变 |
| Nantahala 资本管理Nantahala Capital Management, LLC |
| 1.11% | 1.13% | #6 | $3,332.6万 | 338.3万股 | $3,069.7万 | 553.1万股 | -214.8万股-38.83% | 减仓 |
| ADAR1 Capital Management, LLC |
| 1.43% | 1.24% | #5 | $3,097.9万 | 314.5万股 | $2,103.0万 | 378.9万股 | -64.4万股-17.00% | 减仓 |
| RA资本管理RA CAPITAL MANAGEMENT, L.P. |
| 0.26% | 0.18% | #12 | $2,955.0万 | 300.0万股 | $1,665.0万 | 300.0万股 | 00.00% | 持仓不变 |
| BVF INC/IL |
| 0.76% | 0.53% | #7 | $2,955.0万 | 300.0万股 | $1,665.0万 | 300.0万股 | 00.00% | 持仓不变 |
| Ensign Peak顾问Ensign Peak Advisors, Inc |
| 0.04% | 0.02% | #26 | $2,354.3万 | 239.0万股 | $1,158.3万 | 208.7万股 | +30.3万股+14.52% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #67 | $2,071.3万 | 210.2万股 | $1,022.2万 | 184.1万股 | +26.1万股+14.18% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #76 | $1,683.6万 | 170.9万股 | $678.8万 | 122.3万股 | +48.6万股+39.74% | 加仓 |
| Rhenman & Partners Asset Management AB |
| 1.43% | 0.99% | #4 | $1,515.5万 | 153.9万股 | $798.4万 | 143.9万股 | +10.0万股+6.95% | 加仓 |
| Vestal Point 资本Vestal Point Capital, LP |
| 0.23% | 0.18% | #13 | $994.9万 | 101.0万股 | $635.4万 | 114.5万股 | -13.5万股-11.77% | 减仓 |
| Affinity Asset Advisors, LLC |
| 0.41% | 0.26% | #9 | $898.7万 | 91.2万股 | $506.4万 | 91.2万股 | 00.00% | 持仓不变 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #95 | $866.6万 | 88.0万股 | $476.1万 | 85.8万股 | +2.2万股+2.56% | 加仓 |
| 蒙塔诺瓦资本MONTANOVA CAPITAL, LLC |
| 0.15% | 0.12% | #16 | $837.3万 | 85.0万股 | $471.8万 | 85.0万股 | 00.00% | 持仓不变 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #69 | $740.9万 | 75.2万股 | $780.8万 | 140.7万股 | -65.5万股-46.53% | 减仓 |
| Velan Capital Investment Management LP |
| 4.2% | 2.43% | #2 | $689.5万 | 70.0万股 | $388.5万 | 70.0万股 | 00.00% | 持仓不变 |
| Militia 资本管理Militia Capital Management LLC |
| 0.2% | 0.34% | #14 | $660.0万 | 67.0万股 | $335.8万 | 60.5万股 | +6.5万股+10.74% | 加仓 |
| Assenagon资产管理Assenagon Asset Management S.A. |
| 0.01% | — | #41 | $635.0万 | 64.5万股 | $0 | 0股 | +64.5万股 | 新买入 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #73 | $628.5万 | 63.8万股 | $16.0万 | 2.9万股 | +60.9万股+2,113.82% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #71 | $626.5万 | 63.6万股 | $328.0万 | 59.1万股 | +4.5万股+7.62% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #90 | $540.1万 | 54.8万股 | $260.6万 | 47.0万股 | +7.9万股+16.77% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #68 | $444.3万 | 45.1万股 | $264.4万 | 47.6万股 | -2.5万股-5.31% | 减仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #84 | $374.3万 | 38.0万股 | $230.6万 | 41.5万股 | -3.5万股-8.54% | 减仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | — | #45 | $347.2万 | 35.3万股 | $0 | 0股 | +35.3万股 | 新买入 |
| Federated HermesFEDERATED HERMES, INC. |
| <0.01% | — | #44 | $336.4万 | 34.2万股 | $0 | 0股 | +34.2万股 | 新买入 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| <0.01% | — | #49 | $317.8万 | 32.3万股 | $0 | 0股 | +32.3万股 | 新买入 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #96 | $316.9万 | 32.4万股 | $16.6万 | 3.2万股 | +29.2万股+899.70% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #83 | $248.4万 | 25.2万股 | $126.5万 | 22.8万股 | +2.4万股+10.64% | 加仓 |
| 保德信金融PRUDENTIAL FINANCIAL INC |
| <0.01% | <0.01% | #53 | $241.0万 | 24.5万股 | $7.3万 | 1.3万股 | +23.2万股+1,756.01% | 加仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #80 | $229.2万 | 23.3万股 | $94.7万 | 17.1万股 | +6.2万股+36.34% | 加仓 |
| 景顺Invesco Ltd. |
| <0.01% | <0.01% | #99 | $206.7万 | 21.0万股 | $22.5万 | 4.1万股 | +16.9万股+417.97% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #110 | $190.7万 | 19.4万股 | $38.2万 | 6.9万股 | +12.5万股+181.61% | 加仓 |
| Holocene顾问Holocene Advisors, LP |
| <0.01% | — | #47 | $176.2万 | 17.9万股 | $0 | 0股 | +17.9万股 | 新买入 |
| 纽文Nuveen, LLC |
| <0.01% | <0.01% | #78 | $170.6万 | 17.3万股 | $170.9万 | 30.8万股 | -13.5万股-43.76% | 减仓 |
| Ikarian Capital, LLC |
| 0.17% | 0.17% | #15 | $164.1万 | 16.7万股 | $203.4万 | 36.7万股 | -20.0万股-54.56% | 减仓 |
| Eversept Partners, LP |
| 0.08% | 0.12% | #21 | $163.7万 | 16.6万股 | $222.7万 | 40.1万股 | -23.5万股-58.57% | 减仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #111 | $153.7万 | 15.6万股 | $187.0万 | 33.7万股 | -18.1万股-53.70% | 减仓 |
| 弗雷德·阿尔杰管理FRED ALGER MANAGEMENT, LLC |
| <0.01% | — | #46 | $126.3万 | 12.8万股 | $0 | 0股 | +12.8万股 | 新买入 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #117 | $122.5万 | 12.4万股 | $33.1万 | 7.4万股 | +5.1万股+68.95% | 加仓 |
| Symmetry Investments LP |
| 0.08% | 0.11% | #23 | $117.8万 | 12.0万股 | $101.5万 | 18.3万股 | -6.3万股-34.59% | 减仓 |
| 萨斯奎汉纳组合策略Susquehanna Portfolio Strategies, LLC |
| 0.02% | 0.01% | #32 | $115.7万 | 11.7万股 | $36.8万 | 6.6万股 | +5.1万股+77.08% | 加仓 |
| AWM Investment Company, Inc. |
| 0.1% | 0.07% | #19 | $113.3万 | 11.5万股 | $63.8万 | 11.5万股 | 00.00% | 持仓不变 |
| 巴克莱BARCLAYS PLC |
| <0.01% | <0.01% | #92 | $106.7万 | 10.8万股 | $61.0万 | 11.0万股 | -1,633股-1.49% | 减仓 |
| BEARING POINT CAPITAL, LLC |
| 0.14% | 0.09% | #17 | $100.5万 | 10.2万股 | $56.4万 | 10.2万股 | +500股+0.49% | 加仓 |
| Empower咨询集团Empower Advisory Group, LLC |
| <0.01% | <0.01% | #55 | $99.6万 | 10.1万股 | $56.1万 | 10.1万股 | 00.00% | 持仓不变 |
| RhumbLine顾问RHUMBLINE ADVISERS |
| <0.01% | <0.01% | #72 | $96.4万 | 9.8万股 | $32.8万 | 5.9万股 | +3.9万股+65.34% | 加仓 |
| AQR资本管理AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #82 | $95.6万 | 9.7万股 | $39.3万 | 7.1万股 | +2.6万股+37.10% | 加仓 |
