| Frazier Life Sciences 管理Frazier Life Sciences Management, L.P. |
| 2.95% | 3.56% | #5 | $1.35亿 | 1,246.6万股 | $1.39亿 | 1,246.6万股 | 00.00% | 持仓不变 |
| Medicxi Ventures Management (Jersey) Ltd |
| 45.65% | 8.45% | #1 | $8,099.1万 | 746.5万股 | $8,293.1万 | 746.5万股 | 00.00% | 持仓不变 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #78 | $4,909.8万 | 452.5万股 | $4,512.9万 | 406.2万股 | +46.3万股+11.40% | 加仓 |
| 景顺Invesco Ltd. |
| <0.01% | 0.01% | #57 | $4,372.3万 | 403.0万股 | $4,801.8万 | 432.2万股 | -29.2万股-6.76% | 减仓 |
| 凯雷集团Carlyle Group Inc. |
| 0.38% | 0.37% | #9 | $3,794.0万 | 349.7万股 | $3,885.0万 | 349.7万股 | 00.00% | 持仓不变 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| 0.01% | 0.02% | #40 | $3,662.8万 | 337.6万股 | $4,469.5万 | 402.3万股 | -64.7万股-16.08% | 减仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #81 | $2,882.8万 | 265.7万股 | $2,870.4万 | 258.4万股 | +7.3万股+2.84% | 加仓 |
| GW&K Investment Management, LLC |
| 0.18% | 0.14% | #16 | $2,351.0万 | 216.7万股 | $1,578.9万 | 142.1万股 | +74.6万股+52.48% | 加仓 |
| 富兰克林资源FRANKLIN RESOURCES INC |
| <0.01% | <0.01% | #53 | $2,138.3万 | 197.1万股 | $1,104.9万 | 99.5万股 | +97.6万股+98.17% | 加仓 |
| NEA Management Company, LLC |
| 1.34% | 1.24% | #7 | $2,126.8万 | 196.0万股 | $2,177.7万 | 196.0万股 | 00.00% | 持仓不变 |
| 683 Capital Management, LLC |
| 0.99% | 1.07% | #8 | $2,007.3万 | 185.0万股 | $2,055.4万 | 185.0万股 | 00.00% | 持仓不变 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #63 | $1,929.2万 | 177.8万股 | $695.7万 | 62.6万股 | +115.2万股+183.94% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #88 | $1,721.2万 | 158.6万股 | $1,540.8万 | 138.7万股 | +19.9万股+14.38% | 加仓 |
| Catalys Pacific, LLC |
| 7.06% | 7.19% | #2 | $1,620.8万 | 149.4万股 | $1,659.7万 | 149.4万股 | 00.00% | 持仓不变 |
| 野村资产管理国际NOMURA ASSET MANAGEMENT INTERNATIONAL INC. |
| 0.02% | 0.02% | #31 | $1,587.1万 | 146.3万股 | $1,339.2万 | 120.5万股 | +25.7万股+21.35% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #76 | $1,427.8万 | 131.6万股 | $1,475.7万 | 132.8万股 | -1.2万股-0.93% | 减仓 |
| Wasatch顾问WASATCH ADVISORS LP |
| 0.09% | 0.1% | #22 | $1,418.4万 | 130.7万股 | $1,489.8万 | 134.1万股 | -3.4万股-2.51% | 减仓 |
| Ensign Peak顾问Ensign Peak Advisors, Inc |
| 0.02% | 0.03% | #36 | $1,141.3万 | 105.2万股 | $1,808.5万 | 162.8万股 | -57.6万股-35.38% | 减仓 |
| Propel Bio Management, LLC |
| 5.96% | 5.9% | #3 | $1,139.6万 | 105.0万股 | $935.4万 | 84.1万股 | +20.9万股+24.85% | 加仓 |
| Point72资产管理Point72 Asset Management, L.P. |
| 0.01% | — | #42 | $1,109.1万 | 102.2万股 | $0 | 0股 | +102.2万股 | 新买入 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #100 | $864.3万 | 79.7万股 | $740.0万 | 66.6万股 | +13.1万股+19.61% | 加仓 |
| SummitTX 资本SummitTX Capital, L.P. |
| 0.22% | 0.35% | #15 | $856.7万 | 79.0万股 | $1,106.4万 | 99.6万股 | -20.6万股-20.72% | 减仓 |
| 汇丰控股HSBC HOLDINGS PLC |
| <0.01% | — | #59 | $770.2万 | 71.0万股 | $0 | 0股 | +71.0万股 | 新买入 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #71 | $756.0万 | 69.7万股 | $1,020.1万 | 91.8万股 | -22.1万股-24.11% | 减仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| 0.01% | 0.01% | #50 | $722.7万 | 66.6万股 | $956.2万 | 86.1万股 | -19.5万股-22.61% | 减仓 |
| EcoR1 Capital, LLC |
| 0.33% | 0.29% | #12 | $678.1万 | 62.5万股 | $694.4万 | 62.5万股 | 00.00% | 持仓不变 |
| 洞察顾问PERCEPTIVE ADVISORS LLC |
| 0.09% | 0.2% | #23 | $577.2万 | 53.2万股 | $1,027.7万 | 92.5万股 | -39.3万股-42.49% | 减仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #55 | $563.2万 | 51.9万股 | $535.7万 | 48.2万股 | +3.7万股+7.66% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #84 | $497.3万 | 45.8万股 | $461.0万 | 41.5万股 | +4.3万股+10.45% | 加仓 |
| StepStone Group LP |
| 2.05% | 2.26% | #6 | $468.9万 | 42.2万股 | $468.9万 | 42.2万股 | 00.00% | 持仓不变 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #82 | $454.7万 | 41.9万股 | $454.4万 | 40.9万股 | +1.0万股+2.46% | 加仓 |
| Woodline合伙人Woodline Partners LP |
| 0.01% | 0.02% | #41 | $400.4万 | 36.9万股 | $410.0万 | 36.9万股 | 00.00% | 持仓不变 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #73 | $384.7万 | 35.5万股 | $376.3万 | 33.9万股 | +1.6万股+4.68% | 加仓 |
| Hennion & Walsh Asset Management, Inc. |
| 0.1% | 0.05% | #21 | $355.1万 | 32.7万股 | $162.1万 | 14.6万股 | +18.1万股+124.27% | 加仓 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #80 | $319.0万 | 29.4万股 | $282.4万 | 25.4万股 | +4.0万股+15.64% | 加仓 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #113 | $314.5万 | 29.0万股 | $98.0万 | 8.8万股 | +20.2万股+228.69% | 加仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #124 | $299.2万 | 27.5万股 | $302.7万 | 28.7万股 | -1.2万股-4.24% | 减仓 |
| 简化资产管理Simplify Asset Management Inc. |
| 0.04% | 0.04% | #26 | $270.5万 | 24.9万股 | $291.5万 | 26.2万股 | -1.3万股-5.00% | 减仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #118 | $269.4万 | 24.8万股 | $508.9万 | 45.8万股 | -21.0万股-45.79% | 减仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | 0.01% | #58 | $245.6万 | 22.6万股 | $339.7万 | 30.6万股 | -7.9万股-25.96% | 减仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #110 | $222.0万 | 20.5万股 | $400.4万 | 36.0万股 | -15.6万股-43.23% | 减仓 |
| NewEdge顾问NewEdge Advisors, LLC |
| 0.01% | 0.01% | #49 | $221.3万 | 20.4万股 | $203.3万 | 18.3万股 | +2.1万股+11.45% | 加仓 |
| Avidity Partners Management LP |
| 0.35% | 0.56% | #11 | $217.0万 | 20.0万股 | $277.1万 | 24.9万股 | -4.9万股-19.80% | 减仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #133 | $216.9万 | 20.0万股 | $300.8万 | 25.6万股 | -5.6万股-21.78% | 减仓 |
| 跳跃金融Jump Financial, LLC |
| 0.02% | <0.01% | #38 | $208.2万 | 19.2万股 | $29.4万 | 2.6万股 | +16.5万股+625.53% | 加仓 |
| Opaleye Management Inc. |
| 0.18% | — | #17 | $201.4万 | 18.6万股 | $0 | 0股 | +18.6万股 | 新买入 |
| Trexquant投资Trexquant Investment LP |
| 0.01% | 0.02% | #43 | $188.7万 | 17.4万股 | $325.9万 | 29.3万股 | -11.9万股-40.72% | 减仓 |
| Jones Hill Capital LP |
| 0.37% | — | #10 | $175.2万 | 16.1万股 | $0 | 0股 | +16.1万股 | 新买入 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #111 | $165.3万 | 15.2万股 | $137.8万 | 12.4万股 | +2.8万股+22.82% | 加仓 |
| 富国银行WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #112 | $164.9万 | 15.2万股 | $51.2万 | 4.6万股 | +10.6万股+229.63% | 加仓 |
