| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #78 | $6,983.1万 | 284.9万股 | $3,966.3万 | 226.8万股 | +58.1万股+25.63% | 加仓 |
| Cormorant Asset Management, LP |
| 2.98% | 2.54% | #7 | $5,859.4万 | 239.1万股 | $5,055.7万 | 289.1万股 | -50.0万股-17.30% | 减仓 |
| a16z资本管理a16z Capital Management, L.L.C. |
| 4.5% | 4.38% | #2 | $5,654.8万 | 323.3万股 | $5,654.8万 | 323.3万股 | 00.00% | 持仓不变 |
| Sofinnova Investments, Inc. |
| 2.91% | 1.52% | #8 | $5,622.1万 | 229.4万股 | $4,011.8万 | 229.4万股 | 00.00% | 持仓不变 |
| 木星资产管理Jupiter Topco LLC |
| 0.02% | — | #38 | $5,259.7万 | 214.5万股 | $0 | 0股 | +214.5万股 | 新买入 |
| Octagon Capital Advisors LP |
| 3.85% | 3.38% | #3 | $4,284.3万 | 174.8万股 | $3,057.3万 | 174.8万股 | 00.00% | 持仓不变 |
| RA资本管理RA CAPITAL MANAGEMENT, L.P. |
| 0.36% | 0.31% | #21 | $4,097.2万 | 167.2万股 | $2,887.0万 | 165.1万股 | +2.1万股+1.27% | 加仓 |
| MPM BioImpact LLC |
| 2.49% | — | #9 | $4,087.4万 | 166.8万股 | $0 | 0股 | +166.8万股 | 新买入 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #84 | $3,784.9万 | 154.4万股 | $2,369.7万 | 135.5万股 | +18.9万股+13.97% | 加仓 |
| 极地资本控股Polar Capital Holdings Plc |
| 0.06% | 0.07% | #31 | $2,628.3万 | 107.2万股 | $1,981.0万 | 113.3万股 | -6.0万股-5.32% | 减仓 |
| BRAIDWELL LP |
| 0.94% | 0.7% | #15 | $2,532.2万 | 103.3万股 | $2,099.8万 | 120.1万股 | -16.7万股-13.95% | 减仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #86 | $2,503.6万 | 102.1万股 | $1,488.2万 | 85.1万股 | +17.1万股+20.05% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #73 | $2,461.9万 | 100.4万股 | $1,310.9万 | 74.9万股 | +25.5万股+34.03% | 加仓 |
| Sands Capital Alternatives, LLC |
| 3.14% | 3.27% | #5 | $1,927.4万 | 78.6万股 | $1,375.3万 | 78.6万股 | 00.00% | 持仓不变 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 0.35% | 0.25% | #22 | $1,843.5万 | 75.2万股 | $1,245.0万 | 71.2万股 | +4.0万股+5.67% | 加仓 |
| D.E.肖D. E. Shaw & Co., Inc. |
| 0.01% | 0.01% | #45 | $1,820.5万 | 74.3万股 | $1,222.9万 | 69.9万股 | +4.4万股+6.23% | 加仓 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| 0.02% | 0.03% | #37 | $1,722.7万 | 70.3万股 | $2,321.9万 | 132.8万股 | -62.5万股-47.06% | 减仓 |
| Pivotal bioVenture Partners Investment Advisor LLC |
| 5.2% | 4.08% | #1 | $1,601.4万 | 65.3万股 | $1,142.8万 | 65.3万股 | 00.00% | 持仓不变 |
| Cosmic Management, LLC |
| 3.22% | 3.84% | #4 | $1,230.0万 | 50.2万股 | $877.7万 | 50.2万股 | 00.00% | 持仓不变 |
| STEMPOINT CAPITAL LP |
| 1.62% | 1.09% | #10 | $1,137.7万 | 46.4万股 | $592.3万 | 33.9万股 | +12.6万股+37.06% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #85 | $1,012.1万 | 41.3万股 | $241.0万 | 13.8万股 | +27.5万股+199.68% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #97 | $1,005.3万 | 41.0万股 | $501.9万 | 28.7万股 | +12.3万股+42.94% | 加仓 |
| Squadron Capital Management LLC |
| 3.08% | — | #6 | $992.7万 | 40.5万股 | $0 | 0股 | +40.5万股 | 新买入 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #68 | $966.2万 | 39.4万股 | $374.6万 | 21.5万股 | +18.0万股+83.71% | 加仓 |
| Jacobs Levy股票管理JACOBS LEVY EQUITY MANAGEMENT, INC |
| 0.03% | 0.03% | #34 | $924.2万 | 37.7万股 | $734.8万 | 42.0万股 | -4.3万股-10.24% | 减仓 |
| Walleye资本Walleye Capital LLC |
| 0.03% | 0.01% | #35 | $868.6万 | 35.4万股 | $265.3万 | 15.2万股 | +20.3万股+133.66% | 加仓 |
| 纽文Nuveen, LLC |
| <0.01% | <0.01% | #61 | $855.7万 | 34.9万股 | $85.2万 | 4.9万股 | +30.0万股+617.10% | 加仓 |
| DIADEMA PARTNERS LP |
| 1.05% | 0.18% | #14 | $849.1万 | 34.6万股 | $104.9万 | 6.0万股 | +28.6万股+477.39% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #79 | $841.1万 | 34.3万股 | $392.0万 | 22.4万股 | +11.9万股+53.11% | 加仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.01% | 0.01% | #44 | $735.3万 | 30.0万股 | $874.5万 | 50.0万股 | -20.0万股-40.00% | 减仓 |
| Integral Health 资产管理Integral Health Asset Management, LLC |
| 0.29% | — | #23 | $735.3万 | 30.0万股 | $0 | 0股 | +30.0万股 | 新买入 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #105 | $692.1万 | 28.2万股 | $134.2万 | 22.8万股 | +5.4万股+23.77% | 加仓 |
| 富兰克林资源FRANKLIN RESOURCES INC |
| <0.01% | <0.01% | #71 | $691.1万 | 28.2万股 | $464.1万 | 26.5万股 | +1.7万股+6.25% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #81 | $670.0万 | 27.3万股 | $432.5万 | 24.7万股 | +2.6万股+10.55% | 加仓 |
| Comprehensive Financial 管理Comprehensive Financial Management LLC |
| 0.22% | 0.16% | #24 | $666.3万 | 27.2万股 | $475.5万 | 27.2万股 | 00.00% | 持仓不变 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #93 | $663.7万 | 27.1万股 | $273.6万 | 15.6万股 | +11.4万股+73.08% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #101 | $632.0万 | 25.8万股 | $107.6万 | 6.2万股 | +19.6万股+319.22% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #60 | $606.9万 | 24.8万股 | $752.9万 | 43.0万股 | -18.3万股-42.48% | 减仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #110 | $583.8万 | 23.4万股 | $274.8万 | 17.4万股 | +6.0万股+34.80% | 加仓 |
| ACADIAN ASSET MANAGEMENT LLC |
| 0.01% | 0.01% | #49 | $550.1万 | 22.4万股 | $685.6万 | 39.2万股 | -16.8万股-42.79% | 减仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #75 | $538.2万 | 22.0万股 | $342.7万 | 19.6万股 | +2.4万股+12.08% | 加仓 |
| SPHERA FUNDS MANAGEMENT LTD. |
| 0.68% | 0.24% | #17 | $523.7万 | 21.4万股 | $151.3万 | 8.7万股 | +12.7万股+146.97% | 加仓 |
| Ikarian Capital, LLC |
| 0.52% | — | #18 | $490.2万 | 20.0万股 | $0 | 0股 | +20.0万股 | 新买入 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #121 | $449.9万 | 18.4万股 | $332.8万 | 19.0万股 | -6,735股-3.54% | 减仓 |
| Yiheng Capital Management, L.P. |
| 1.55% | — | #12 | $418.0万 | 17.1万股 | $0 | 0股 | +17.1万股 | 新买入 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| 0.01% | <0.01% | #51 | $406.1万 | 16.6万股 | $242.4万 | 13.9万股 | +2.7万股+19.56% | 加仓 |
| Ensign Peak顾问Ensign Peak Advisors, Inc |
| 0.01% | 0.01% | #50 | $347.3万 | 14.2万股 | $290.7万 | 16.6万股 | -2.5万股-14.75% | 减仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #103 | $339.6万 | 13.9万股 | $30.1万 | 1.7万股 | +12.1万股+705.61% | 加仓 |
| 景顺Invesco Ltd. |
| <0.01% | <0.01% | #117 | $312.3万 | 12.7万股 | $308.0万 | 17.6万股 | -4.9万股-27.65% | 减仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #100 | $263.1万 | 10.7万股 | $132.2万 | 7.6万股 | +3.2万股+42.03% | 加仓 |
