| 富达投资FMR LLC |
| 0.01% | 0.01% | #37 | $1.31亿 | 3,743.0万股 | $1.08亿 | 3,743.0万股 | -769股-0.00% | 减仓 |
| Flagship Pioneering, LLC |
| 5.67% | 6.2% | #1 | $8,725.6万 | 2,500.2万股 | $7,200.5万 | 2,500.2万股 | 00.00% | 持仓不变 |
| RA资本管理RA CAPITAL MANAGEMENT, L.P. |
| 0.57% | — | #4 | $6,543.8万 | 1,875.0万股 | $0 | 0股 | +1,875.0万股 | 新买入 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #83 | $5,819.6万 | 1,667.5万股 | $4,101.2万 | 1,424.0万股 | +243.5万股+17.10% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #78 | $3,909.9万 | 1,120.3万股 | $3,035.0万 | 1,053.8万股 | +66.5万股+6.31% | 加仓 |
| 加拿大养老金计划投资委员会(CPPIB)CANADA PENSION PLAN INVESTMENT BOARD |
| 0.02% | 0.02% | #20 | $3,566.2万 | 1,021.8万股 | $2,943.9万 | 1,022.2万股 | -3,500股-0.03% | 减仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #98 | $2,923.0万 | 837.5万股 | $2,141.2万 | 743.5万股 | +94.1万股+12.65% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #75 | $2,006.2万 | 574.8万股 | $848.7万 | 294.7万股 | +280.2万股+95.07% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #82 | $1,632.9万 | 467.8万股 | $1,204.6万 | 418.2万股 | +49.6万股+11.86% | 加仓 |
| Marex集团Marex Group plc |
| 0.06% | 0.07% | #12 | $1,392.2万 | 398.9万股 | $1,151.7万 | 399.9万股 | -1.0万股-0.25% | 减仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| 0.01% | <0.01% | #32 | $1,023.1万 | 293.1万股 | $191.4万 | 66.4万股 | +226.7万股+341.18% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #89 | $826.4万 | 236.8万股 | $916.2万 | 318.1万股 | -81.3万股-25.56% | 减仓 |
| Alphabet公司Alphabet Inc. |
| 0.19% | 0.2% | #6 | $810.0万 | 281.3万股 | $810.0万 | 281.3万股 | 00.00% | 持仓不变 |
| Integral Health 资产管理Integral Health Asset Management, LLC |
| 0.28% | 0.44% | #5 | $698.0万 | 200.0万股 | $921.6万 | 320.0万股 | -120.0万股-37.50% | 减仓 |
| 多伦多道明银行TORONTO DOMINION BANK |
| 0.01% | — | #33 | $688.4万 | 197.2万股 | $0 | 0股 | +197.2万股 | 新买入 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #125 | $656.7万 | 188.2万股 | $491.8万 | 170.8万股 | +17.4万股+10.20% | 加仓 |
| Jacobs Levy股票管理JACOBS LEVY EQUITY MANAGEMENT, INC |
| 0.02% | — | #18 | $652.2万 | 186.9万股 | $0 | 0股 | +186.9万股 | 新买入 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #93 | $559.8万 | 160.4万股 | $425.9万 | 147.9万股 | +12.5万股+8.47% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #95 | $481.3万 | 137.9万股 | $393.5万 | 136.6万股 | +1.3万股+0.95% | 加仓 |
| Woodline合伙人Woodline Partners LP |
| 0.01% | 0.01% | #25 | $460.0万 | 131.8万股 | $379.6万 | 131.8万股 | 00.00% | 持仓不变 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #81 | $431.9万 | 123.7万股 | $306.3万 | 106.4万股 | +17.4万股+16.34% | 加仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| 0.01% | 0.01% | #36 | $429.7万 | 123.1万股 | $417.9万 | 145.1万股 | -22.0万股-15.17% | 减仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #135 | $397.8万 | 114.0万股 | $311.2万 | 87.7万股 | +26.3万股+30.04% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #106 | $370.4万 | 106.1万股 | $390.3万 | 135.5万股 | -29.4万股-21.68% | 减仓 |
| AQR资本管理AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #77 | $336.1万 | 96.3万股 | $323.8万 | 112.4万股 | -16.1万股-14.33% | 减仓 |
| Omega Fund Management, LLC |
| 1.59% | 1.49% | #3 | $294.5万 | 84.4万股 | $243.0万 | 84.4万股 | 00.00% | 持仓不变 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #152 | $268.2万 | 77.7万股 | $210.6万 | 78.6万股 | -8,536股-1.09% | 减仓 |
| Crestline Management, L.P. |
| 4.93% | 4.7% | #2 | $263.8万 | 75.6万股 | $217.7万 | 75.6万股 | 00.00% | 持仓不变 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #137 | $255.2万 | 73.1万股 | $197.5万 | 68.6万股 | +4.5万股+6.62% | 加仓 |
| ArrowMark Colorado Holdings LLC |
| 0.1% | 0.05% | #10 | $239.1万 | 68.5万股 | $197.3万 | 68.5万股 | 00.00% | 持仓不变 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #87 | $228.1万 | 65.4万股 | $458.2万 | 159.1万股 | -93.8万股-58.93% | 减仓 |
| DEUTSCHE 银行 AG\DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #92 | $225.1万 | 64.5万股 | $170.5万 | 59.2万股 | +5.3万股+8.98% | 加仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #66 | $223.0万 | 63.9万股 | $345.2万 | 119.9万股 | -56.0万股-46.70% | 减仓 |
| Corient私人财富Corient Private Wealth LLC |
| <0.01% | <0.01% | #65 | $219.2万 | 62.8万股 | $184.9万 | 64.2万股 | -1.4万股-2.16% | 减仓 |
| Point72资产管理Point72 Asset Management, L.P. |
| <0.01% | — | #55 | $207.7万 | 59.5万股 | $0 | 0股 | +59.5万股 | 新买入 |
| 景顺Invesco Ltd. |
| <0.01% | <0.01% | #154 | $176.0万 | 50.4万股 | $163.9万 | 56.9万股 | -6.5万股-11.41% | 减仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #127 | $166.7万 | 47.8万股 | $127.5万 | 44.3万股 | +3.5万股+7.89% | 加仓 |
| 纽文Nuveen, LLC |
| <0.01% | <0.01% | #124 | $129.0万 | 37.0万股 | $94.2万 | 32.7万股 | +4.3万股+13.07% | 加仓 |
| 瑞士央行Swiss National Bank |
| <0.01% | <0.01% | #96 | $121.5万 | 34.8万股 | $98.7万 | 34.3万股 | +5,500股+1.61% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #155 | $119.3万 | 34.2万股 | $221.7万 | 77.0万股 | -42.8万股-55.59% | 减仓 |
| 贝克兄弟顾问BAKER BROS. ADVISORS LP |
| 0.01% | 0.01% | #40 | $108.4万 | 31.0万股 | $89.4万 | 31.0万股 | 00.00% | 持仓不变 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #139 | $102.9万 | 29.5万股 | $83.9万 | 29.1万股 | +3,574股+1.23% | 加仓 |
| 瑞银资产管理(美洲)UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
| <0.01% | <0.01% | #142 | $99.3万 | 28.4万股 | $66.7万 | 23.2万股 | +5.3万股+22.77% | 加仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #170 | $98.7万 | 28.3万股 | $59.8万 | 20.7万股 | +7.5万股+36.35% | 加仓 |
| 花旗集团CITIGROUP INC |
| <0.01% | <0.01% | #122 | $95.1万 | 27.3万股 | $17.4万 | 6.0万股 | +21.2万股+351.27% | 加仓 |
| XTX资本XTX Topco Ltd |
| 0.01% | 0.01% | #26 | $79.1万 | 22.7万股 | $31.8万 | 11.0万股 | +11.6万股+105.41% | 加仓 |
| RhumbLine顾问RHUMBLINE ADVISERS |
| <0.01% | <0.01% | #99 | $78.0万 | 22.3万股 | $57.2万 | 19.9万股 | +2.5万股+12.44% | 加仓 |
| Rafferty资产管理Rafferty Asset Management, LLC |
| <0.01% | <0.01% | #67 | $68.7万 | 19.7万股 | $101.8万 | 35.4万股 | -15.7万股-44.36% | 减仓 |
| 洛杉矶资本管理LOS ANGELES CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #53 | $67.5万 | 19.3万股 | $21.6万 | 7.5万股 | +11.8万股+158.31% | 加仓 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
| <0.01% | <0.01% | #100 | $63.4万 | 18.2万股 | $47.1万 | 16.4万股 | +1.8万股+11.12% | 加仓 |
