| RA资本管理RA CAPITAL MANAGEMENT, L.P. |
| 2.04% | 1.78% | #6 | $2.34亿 | 699.6万股 | $1.68亿 | 699.6万股 | 00.00% | 持仓不变 |
| TRV GP V, LLC |
| 41.78% | 37.25% | #2 | $2.08亿 | 621.6万股 | $1.49亿 | 621.6万股 | 00.00% | 持仓不变 |
| Driehaus资本管理DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.86% | 0.78% | #11 | $1.48亿 | 443.3万股 | $1.06亿 | 439.6万股 | +3.7万股+0.85% | 加仓 |
| TRV GP VI, LLC |
| 60.72% | 74.64% | #1 | $1.41亿 | 421.2万股 | $1.01亿 | 421.2万股 | 00.00% | 持仓不变 |
| Samsara BioCapital, LLC |
| 8.66% | 7.35% | #3 | $1.05亿 | 314.9万股 | $7,567.4万 | 314.9万股 | 00.00% | 持仓不变 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| 0.01% | 0.01% | #42 | $1.03亿 | 306.3万股 | $6,984.1万 | 290.6万股 | +15.6万股+5.38% | 加仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #70 | $6,470.6万 | 193.2万股 | $4,378.7万 | 182.2万股 | +11.0万股+6.03% | 加仓 |
| Siren, L.L.C. |
| 1.29% | 1.33% | #9 | $6,363.1万 | 190.0万股 | $4,806.0万 | 200.0万股 | -10.0万股-5.00% | 减仓 |
| Avoro资本顾问Avoro Capital Advisors LLC |
| 0.4% | 0.32% | #15 | $4,479.3万 | 133.8万股 | $3,214.0万 | 133.8万股 | 00.00% | 持仓不变 |
| 木星资产管理Jupiter Topco LLC |
| 0.02% | — | #37 | $4,372.3万 | 130.8万股 | $0 | 0股 | +130.8万股 | 新买入 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #72 | $4,091.4万 | 122.2万股 | $2,876.3万 | 119.7万股 | +2.5万股+2.06% | 加仓 |
| PRIMECAP管理PRIMECAP MANAGEMENT CO/CA/ |
| 0.02% | 0.02% | #33 | $3,909.6万 | 116.7万股 | $2,520.3万 | 104.9万股 | +11.9万股+11.30% | 加仓 |
| First Light Asset Management, LLC |
| 1.96% | 1.58% | #7 | $3,226.0万 | 96.3万股 | $1,761.1万 | 73.3万股 | +23.0万股+31.44% | 加仓 |
| ADAR1 Capital Management, LLC |
| 1.45% | 1.54% | #8 | $3,150.6万 | 94.1万股 | $2,618.8万 | 109.0万股 | -14.9万股-13.68% | 减仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #66 | $2,275.0万 | 67.9万股 | $1,550.6万 | 64.5万股 | +3.4万股+5.27% | 加仓 |
| Caption管理Caption Management, LLC |
| 0.11% | — | #23 | $2,270.6万 | 67.8万股 | $0 | 0股 | +67.8万股 | 新买入 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #84 | $2,185.7万 | 65.3万股 | $1,517.4万 | 63.1万股 | +2.1万股+3.35% | 加仓 |
| 卢米斯塞勒斯LOOMIS SAYLES & CO L P |
| 0.03% | — | #31 | $2,092.3万 | 62.5万股 | $0 | 0股 | +62.5万股 | 新买入 |
| Casdin Capital, LLC |
| 0.93% | 1.01% | #10 | $1,852.9万 | 55.3万股 | $1,329.5万 | 55.3万股 | 00.00% | 持仓不变 |
| Catalio Capital Management, LP |
| 3.37% | 1.48% | #5 | $1,795.6万 | 53.6万股 | $707.3万 | 29.4万股 | +24.2万股+82.14% | 加仓 |
| Algert全球ALGERT GLOBAL LLC |
| 0.16% | 0.01% | #21 | $1,331.2万 | 39.7万股 | $50.5万 | 2.1万股 | +37.6万股+1,789.65% | 加仓 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| 0.01% | 0.01% | #39 | $1,173.6万 | 35.0万股 | $568.7万 | 23.7万股 | +11.4万股+48.07% | 加仓 |
| 都铎投资TUDOR INVESTMENT CORP ET AL |
| 0.02% | — | #38 | $1,101.7万 | 32.9万股 | $0 | 0股 | +32.9万股 | 新买入 |
| Longaeva 合伙人Longaeva Partners L.P. |
| 0.22% | 0.07% | #20 | $998.6万 | 29.8万股 | $179.2万 | 7.5万股 | +22.4万股+299.87% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #79 | $991.0万 | 29.6万股 | $175.4万 | 7.3万股 | +22.3万股+305.34% | 加仓 |
| Soleus 资本管理Soleus Capital Management, L.P. |
| 0.32% | 0.27% | #16 | $921.0万 | 27.5万股 | $660.8万 | 27.5万股 | 00.00% | 持仓不变 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #98 | $770.9万 | 23.0万股 | $468.7万 | 19.5万股 | +3.5万股+18.02% | 加仓 |
| Universal投资服务Universal- Beteiligungs- und Servicegesellschaft mbH |
| 0.01% | 0.01% | #41 | $745.8万 | 22.3万股 | $538.3万 | 22.4万股 | -1,293股-0.58% | 减仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| 0.01% | <0.01% | #48 | $739.7万 | 22.1万股 | $181.1万 | 7.5万股 | +14.6万股+193.08% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #78 | $673.6万 | 20.1万股 | $395.4万 | 16.5万股 | +3.7万股+22.25% | 加仓 |
| Kalehua Capital Management LLC |
| 4.67% | 3.31% | #4 | $651.5万 | 19.5万股 | $467.5万 | 19.5万股 | 00.00% | 持仓不变 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #75 | $626.4万 | 18.7万股 | $436.3万 | 18.2万股 | +5,461股+3.01% | 加仓 |
| Woodline合伙人Woodline Partners LP |
| 0.02% | — | #36 | $621.4万 | 18.6万股 | $0 | 0股 | +18.6万股 | 新买入 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #65 | $554.8万 | 16.6万股 | $371.2万 | 15.4万股 | +1.1万股+7.23% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #113 | $450.0万 | 13.4万股 | $102.4万 | 5.4万股 | +8.0万股+146.75% | 加仓 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | — | #108 | $344.1万 | 10.3万股 | $0 | 0股 | +10.3万股 | 新买入 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #94 | $301.0万 | 9.0万股 | $281.1万 | 11.7万股 | -2.7万股-23.17% | 减仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #123 | $296.4万 | 8.5万股 | $197.3万 | 8.5万股 | +627股+0.74% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | — | #100 | $295.2万 | 8.8万股 | $0 | 0股 | +8.8万股 | 新买入 |
| Federated HermesFEDERATED HERMES, INC. |
| <0.01% | <0.01% | #50 | $290.5万 | 8.7万股 | $214.6万 | 8.9万股 | -2,548股-2.85% | 减仓 |
| 拉扎德资产管理LAZARD ASSET MANAGEMENT LLC |
| <0.01% | — | #51 | $252.6万 | 7.5万股 | $0 | 0股 | +7.5万股 | 新买入 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | — | #88 | $252.3万 | 7.5万股 | $0 | 0股 | +7.5万股 | 新买入 |
| 箭街资本ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
| <0.01% | — | #67 | $250.0万 | 7.5万股 | $0 | 0股 | +7.5万股 | 新买入 |
| Jacobs Levy股票管理JACOBS LEVY EQUITY MANAGEMENT, INC |
| 0.01% | <0.01% | #43 | $228.3万 | 6.8万股 | $68.3万 | 2.8万股 | +4.0万股+139.77% | 加仓 |
| HUSSMAN STRATEGIC ADVISORS, INC. |
| 0.49% | 0.55% | #12 | $211.0万 | 6.3万股 | $252.3万 | 10.5万股 | -4.2万股-40.00% | 减仓 |
| 美国世纪投资AMERICAN CENTURY COMPANIES INC |
| <0.01% | <0.01% | #71 | $204.2万 | 6.1万股 | $147.3万 | 6.1万股 | -317股-0.52% | 减仓 |
| DIADEMA PARTNERS LP |
| 0.25% | <0.01% | #17 | $199.9万 | 6.0万股 | $4,854 | 202股 | +5.9万股+29,454.46% | 加仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #105 | $188.1万 | 5.6万股 | $141.1万 | 5.9万股 | -2,533股-4.31% | 减仓 |
| XTX资本XTX Topco Ltd |
| 0.02% | 0.02% | #32 | $182.5万 | 5.4万股 | $88.2万 | 3.7万股 | +1.8万股+48.38% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #86 | $169.3万 | 5.1万股 | $298.2万 | 12.4万股 | -7.4万股-59.26% | 减仓 |
