| 富达投资FMR LLC |
| <0.01% | <0.01% | #60 | $9,425.2万 | 510.0万股 | $4,299.1万 | 287.9万股 | +222.1万股+77.12% | 加仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #78 | $8,067.5万 | 436.6万股 | $488.3万 | 32.7万股 | +403.8万股+1,234.70% | 加仓 |
| 深轨资本Deep Track Capital, LP |
| 0.97% | — | #18 | $6,671.3万 | 361.0万股 | $0 | 0股 | +361.0万股 | 新买入 |
| Caligan Partners LP |
| 2.75% | 1.62% | #2 | $5,846.8万 | 316.4万股 | $2,441.1万 | 163.5万股 | +152.9万股+93.51% | 加仓 |
| TCG Crossover 管理TCG Crossover Management, LLC |
| 1.34% | 0.32% | #12 | $5,575.6万 | 301.7万股 | $1,102.4万 | 73.8万股 | +227.9万股+308.61% | 加仓 |
| Affinity Asset Advisors, LLC |
| 2.42% | 1.03% | #6 | $5,359.2万 | 290.0万股 | $2,001.9万 | 134.1万股 | +155.9万股+116.28% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #73 | $5,339.4万 | 288.9万股 | $107.0万 | 7.2万股 | +281.8万股+3,932.28% | 加仓 |
| 法伦资本FARALLON CAPITAL MANAGEMENT, L.L.C. |
| 0.21% | 0.08% | #32 | $4,616.3万 | 249.8万股 | $1,367.6万 | 91.6万股 | +158.2万股+172.71% | 加仓 |
| Point72资产管理Point72 Asset Management, L.P. |
| 0.05% | 0.02% | #41 | $4,411.2万 | 238.7万股 | $1,367.8万 | 91.6万股 | +147.1万股+160.55% | 加仓 |
| Avoro资本顾问Avoro Capital Advisors LLC |
| 0.39% | 0.21% | #29 | $4,312.0万 | 233.3万股 | $2,105.1万 | 141.0万股 | +92.3万股+65.48% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #86 | $4,184.3万 | 226.4万股 | $1,074.5万 | 72.0万股 | +154.5万股+214.61% | 加仓 |
| BVF INC/IL |
| 0.98% | 0.78% | #17 | $3,835.6万 | 207.6万股 | $2,437.8万 | 163.3万股 | +44.3万股+27.11% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #68 | $3,536.8万 | 191.4万股 | $960.0万 | 64.3万股 | +127.1万股+197.64% | 加仓 |
| Nantahala 资本管理Nantahala Capital Management, LLC |
| 1.15% | 0.68% | #13 | $3,441.4万 | 186.2万股 | $1,843.9万 | 123.5万股 | +62.7万股+50.79% | 加仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.04% | 0.02% | #44 | $3,195.2万 | 172.9万股 | $1,275.0万 | 85.4万股 | +87.5万股+102.46% | 加仓 |
| Soleus 资本管理Soleus Capital Management, L.P. |
| 1.05% | 0.27% | #16 | $3,058.4万 | 165.5万股 | $659.9万 | 44.2万股 | +121.3万股+274.45% | 加仓 |
| BRAIDWELL LP |
| 1.11% | — | #15 | $3,010.7万 | 162.9万股 | $0 | 0股 | +162.9万股 | 新买入 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | — | #65 | $2,424.0万 | 131.2万股 | $0 | 0股 | +131.2万股 | 新买入 |
| 联博ALLIANCEBERNSTEIN L.P. |
| 0.01% | — | #59 | $2,329.8万 | 126.1万股 | $0 | 0股 | +126.1万股 | 新买入 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #63 | $2,234.3万 | 120.9万股 | $1,705.0万 | 114.2万股 | +6.7万股+5.87% | 加仓 |
| Logos Global Management LP |
| 0.91% | 0.97% | #20 | $2,125.2万 | 115.0万股 | $1,940.9万 | 130.0万股 | -15.0万股-11.54% | 减仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #80 | $2,042.8万 | 110.5万股 | $253.8万 | 17.0万股 | +93.5万股+550.49% | 加仓 |
| Commodore Capital LP |
| 1.12% | 0.42% | #14 | $1,881.9万 | 101.8万股 | $721.1万 | 48.3万股 | +53.5万股+110.83% | 加仓 |
| RA资本管理RA CAPITAL MANAGEMENT, L.P. |
| 0.16% | 0.1% | #35 | $1,848.0万 | 100.0万股 | $989.8万 | 66.3万股 | +33.7万股+50.84% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #75 | $1,748.8万 | 94.6万股 | $89.7万 | 6.0万股 | +88.6万股+1,474.42% | 加仓 |
| Trails Edge Capital Partners, LP |
| 2.62% | — | #3 | $1,648.2万 | 89.2万股 | $0 | 0股 | +89.2万股 | 新买入 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #61 | $1,647.3万 | 89.1万股 | $257.0万 | 17.2万股 | +71.9万股+417.81% | 加仓 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| 0.02% | 0.01% | #50 | $1,592.4万 | 86.2万股 | $1,092.3万 | 73.2万股 | +13.0万股+17.79% | 加仓 |
| Vestal Point 资本Vestal Point Capital, LP |
| 0.33% | — | #31 | $1,432.2万 | 77.5万股 | $0 | 0股 | +77.5万股 | 新买入 |
| Seven Fleet Capital Management LP |
| 2.35% | 1.01% | #8 | $1,424.4万 | 77.1万股 | $319.2万 | 21.4万股 | +55.7万股+260.48% | 加仓 |
| Parkman Healthcare Partners LLC |
| 1.45% | — | #11 | $1,416.1万 | 76.6万股 | $0 | 0股 | +76.6万股 | 新买入 |
| 布斯湾基金管理BOOTHBAY FUND MANAGEMENT, LLC |
| 0.17% | 0.09% | #34 | $1,297.4万 | 70.2万股 | $725.2万 | 48.6万股 | +21.6万股+44.53% | 加仓 |
| SquarepointSquarepoint Ops LLC |
| 0.01% | <0.01% | #55 | $1,088.9万 | 58.9万股 | $121.4万 | 8.1万股 | +50.8万股+624.91% | 加仓 |
| Caption管理Caption Management, LLC |
| 0.05% | 0.09% | #43 | $1,025.3万 | 55.5万股 | $1,622.4万 | 108.7万股 | -53.2万股-48.95% | 减仓 |
| 贝克兄弟顾问BAKER BROS. ADVISORS LP |
| 0.05% | — | #40 | $1,016.4万 | 55.0万股 | $0 | 0股 | +55.0万股 | 新买入 |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 0.96% | — | #19 | $924.7万 | 50.0万股 | $0 | 0股 | +50.0万股 | 新买入 |
| Davern Capital Partners, LP |
| 1.48% | — | #10 | $866.1万 | 46.9万股 | $0 | 0股 | +46.9万股 | 新买入 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #82 | $832.0万 | 45.0万股 | $389.0万 | 26.1万股 | +19.0万股+72.81% | 加仓 |
| Pivotal bioVenture Partners Investment Advisor LLC |
| 2.61% | 1.58% | #4 | $802.1万 | 43.4万股 | $441.8万 | 29.6万股 | +13.8万股+46.67% | 加仓 |
| 富兰克林资源FRANKLIN RESOURCES INC |
| <0.01% | — | #74 | $746.9万 | 40.4万股 | $0 | 0股 | +40.4万股 | 新买入 |
| Boxer Capital Management, LLC |
| 0.52% | 0.59% | #25 | $693.0万 | 37.5万股 | $447.9万 | 30.0万股 | +7.5万股+25.00% | 加仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| 0.01% | <0.01% | #57 | $660.1万 | 35.7万股 | $179.3万 | 12.0万股 | +23.7万股+197.38% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #89 | $636.7万 | 34.5万股 | $45.6万 | 3.1万股 | +31.4万股+1,027.51% | 加仓 |
| DV EQUITIES, LLC |
| 0.88% | — | #21 | $613.9万 | 33.2万股 | $0 | 0股 | +33.2万股 | 新买入 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #76 | $600.2万 | 32.5万股 | $129.0万 | 8.6万股 | +23.8万股+275.79% | 加仓 |
| Velan Capital Investment Management LP |
| 3.65% | 1.73% | #1 | $599.6万 | 32.4万股 | $276.4万 | 18.5万股 | +13.9万股+75.26% | 加仓 |
| Schonfeld战略顾问Schonfeld Strategic Advisors LLC |
| 0.02% | — | #49 | $572.9万 | 31.0万股 | $0 | 0股 | +31.0万股 | 新买入 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #95 | $527.8万 | 28.6万股 | $951.3万 | 63.7万股 | -35.2万股-55.17% | 减仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #102 | $526.1万 | 28.5万股 | $0 | 0股 | +28.5万股 | 新买入 |
| Vivo Capital, LLC |
| 0.46% | — | #27 | $508.2万 | 27.5万股 | $0 | 0股 | +27.5万股 | 新买入 |
