| 富达投资FMR LLC |
| 0.01% | 0.01% | #60 | $3.00亿 | 1,672.8万股 | $2.31亿 | 1,663.1万股 | +9.7万股+0.59% | 加仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #96 | $1.59亿 | 882.7万股 | $1.23亿 | 882.9万股 | -1,751股-0.02% | 减仓 |
| 洞察顾问PERCEPTIVE ADVISORS LLC |
| 2.25% | 2.25% | #9 | $1.50亿 | 833.5万股 | $1.15亿 | 828.5万股 | +5.0万股+0.60% | 加仓 |
| TCG Crossover 管理TCG Crossover Management, LLC |
| 2.7% | 2.48% | #6 | $1.12亿 | 624.4万股 | $8,678.9万 | 624.4万股 | 00.00% | 持仓不变 |
| Commodore Capital LP |
| 6.04% | 4.54% | #2 | $1.01亿 | 565.0万股 | $7,853.5万 | 565.0万股 | 00.00% | 持仓不变 |
| 木星资产管理Jupiter Topco LLC |
| 0.04% | — | #49 | $9,401.4万 | 523.6万股 | $0 | 0股 | +523.6万股 | 新买入 |
| Saturn V Capital Management LP |
| 11.91% | 10.95% | #1 | $8,304.9万 | 462.4万股 | $6,046.3万 | 435.0万股 | +27.4万股+6.30% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #108 | $7,586.7万 | 422.4万股 | $5,756.8万 | 414.2万股 | +8.3万股+2.00% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #88 | $5,622.9万 | 313.1万股 | $2,650.5万 | 195.0万股 | +118.1万股+60.53% | 加仓 |
| Driehaus资本管理DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.32% | 0.31% | #23 | $5,454.4万 | 303.7万股 | $4,152.1万 | 298.7万股 | +5.0万股+1.67% | 加仓 |
| First Light Asset Management, LLC |
| 3.3% | 3.97% | #5 | $5,429.8万 | 302.3万股 | $4,435.0万 | 319.1万股 | -16.7万股-5.25% | 减仓 |
| 富兰克林资源FRANKLIN RESOURCES INC |
| 0.01% | 0.01% | #64 | $5,298.6万 | 295.0万股 | $3,143.6万 | 226.2万股 | +68.9万股+30.45% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #77 | $5,133.4万 | 285.8万股 | $3,650.1万 | 262.6万股 | +23.2万股+8.84% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #113 | $4,675.6万 | 260.3万股 | $3,284.8万 | 236.3万股 | +24.0万股+10.16% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #97 | $4,194.9万 | 233.5万股 | $3,073.7万 | 221.1万股 | +12.4万股+5.63% | 加仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #102 | $3,492.2万 | 186.4万股 | $203.7万 | 16.0万股 | +170.4万股+1,067.24% | 加仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.05% | 0.08% | #43 | $3,412.4万 | 190.0万股 | $4,949.5万 | 356.1万股 | -166.1万股-46.64% | 减仓 |
| Siren, L.L.C. |
| 0.54% | 0.47% | #17 | $2,659.1万 | 148.1万股 | $1,709.7万 | 123.0万股 | +25.1万股+20.37% | 加仓 |
| 683 Capital Management, LLC |
| 1.21% | 1.18% | #12 | $2,471.5万 | 137.6万股 | $2,261.0万 | 162.7万股 | -25.0万股-15.40% | 减仓 |
| 暮色资产管理EVENTIDE ASSET MANAGEMENT, LLC |
| 0.32% | 0.35% | #22 | $2,384.4万 | 132.8万股 | $2,104.2万 | 151.4万股 | -18.6万股-12.31% | 减仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #125 | $1,906.5万 | 106.2万股 | $1,313.2万 | 94.5万股 | +11.7万股+12.36% | 加仓 |
| Alyeska投资集团Alyeska Investment Group, L.P. |
| 0.05% | — | #42 | $1,891.2万 | 105.3万股 | $0 | 0股 | +105.3万股 | 新买入 |
| Almitas Capital LLC |
| 4.08% | 6.67% | #3 | $1,750.9万 | 97.5万股 | $2,950.4万 | 212.3万股 | -114.8万股-54.07% | 减仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #89 | $1,621.5万 | 90.2万股 | $1,254.4万 | 90.3万股 | -729股-0.08% | 减仓 |
| Jones Hill Capital LP |
| 3.41% | 4.76% | #4 | $1,605.7万 | 89.4万股 | $2,222.3万 | 159.9万股 | -70.5万股-44.08% | 减仓 |
| Woodline合伙人Woodline Partners LP |
| 0.05% | 0.04% | #44 | $1,520.1万 | 84.6万股 | $1,175.7万 | 84.6万股 | +587股+0.07% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #106 | $1,493.8万 | 83.2万股 | $1,084.1万 | 78.0万股 | +5.2万股+6.65% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #121 | $1,476.0万 | 82.2万股 | $1,849.7万 | 133.1万股 | -50.9万股-38.24% | 减仓 |
| Boxer Capital Management, LLC |
| 1.08% | 1.46% | #13 | $1,436.8万 | 80.0万股 | $1,112.0万 | 80.0万股 | 00.00% | 持仓不变 |
| 安本标准投资Aberdeen Group plc |
| 0.02% | — | #57 | $1,324.9万 | 73.8万股 | $0 | 0股 | +73.8万股 | 新买入 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #107 | $1,302.2万 | 72.5万股 | $995.6万 | 71.6万股 | +8,805股+1.23% | 加仓 |
| Connor Clark & Lunn投资管理Connor, Clark & Lunn Investment Management Ltd. |
| 0.02% | 0.03% | #53 | $1,294.9万 | 72.1万股 | $1,207.0万 | 86.8万股 | -14.7万股-16.97% | 减仓 |
| GREAT POINT PARTNERS LLC |
| 2.38% | 5.59% | #8 | $1,257.2万 | 70.0万股 | $2,432.5万 | 175.0万股 | -105.0万股-60.00% | 减仓 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| 0.02% | 0.02% | #59 | $1,230.2万 | 68.5万股 | $1,539.1万 | 110.7万股 | -42.2万股-38.14% | 减仓 |
| Qube研究科技Qube Research & Technologies Ltd |
| 0.01% | 0.01% | #63 | $1,223.8万 | 68.1万股 | $976.1万 | 70.2万股 | -2.1万股-2.97% | 减仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #94 | $1,119.0万 | 62.3万股 | $814.8万 | 58.6万股 | +3.7万股+6.30% | 加仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| 0.01% | <0.01% | #72 | $1,065.8万 | 59.3万股 | $225.1万 | 16.2万股 | +43.1万股+266.44% | 加仓 |
| DEUTSCHE 银行 AG\DEUTSCHE BANK AG\ |
| <0.01% | 0.01% | #91 | $1,002.1万 | 55.8万股 | $1,762.2万 | 126.8万股 | -71.0万股-55.99% | 减仓 |
| ADAR1 Capital Management, LLC |
| 0.44% | 0.82% | #19 | $959.9万 | 53.4万股 | $1,390.8万 | 100.1万股 | -46.6万股-46.58% | 减仓 |
| Rock Springs Capital Management LP |
| 0.44% | 0.41% | #20 | $897.6万 | 50.0万股 | $694.7万 | 50.0万股 | 00.00% | 持仓不变 |
| Nantahala 资本管理Nantahala Capital Management, LLC |
| 0.29% | 0.27% | #24 | $874.1万 | 48.7万股 | $744.6万 | 53.6万股 | -4.9万股-9.15% | 减仓 |
| Federated HermesFEDERATED HERMES, INC. |
| 0.01% | 0.01% | #62 | $830.1万 | 46.2万股 | $505.3万 | 36.4万股 | +9.9万股+27.14% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #135 | $804.3万 | 44.8万股 | $492.1万 | 35.4万股 | +9.4万股+26.51% | 加仓 |
| 近水资本市场Nearwater Capital Markets, Ltd |
| 0.13% | — | #33 | $763.3万 | 42.5万股 | $0 | 0股 | +42.5万股 | 新买入 |
| Parkman Healthcare Partners LLC |
| 0.73% | 0.89% | #16 | $716.2万 | 39.9万股 | $863.8万 | 62.1万股 | -22.3万股-35.83% | 减仓 |
| HighVista Strategies LLC |
| 1.58% | 1.35% | #11 | $693.4万 | 38.6万股 | $489.4万 | 35.2万股 | +3.4万股+9.66% | 加仓 |
| STEMPOINT CAPITAL LP |
| 0.98% | 1.72% | #14 | $690.2万 | 38.4万股 | $930.9万 | 67.0万股 | -28.5万股-42.61% | 减仓 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #141 | $677.4万 | 37.7万股 | $35.6万 | 2.6万股 | +35.2万股+1,373.30% | 加仓 |
| Logos Global Management LP |
| 0.27% | 0.49% | #25 | $628.6万 | 35.0万股 | $973.0万 | 70.0万股 | -35.0万股-50.00% | 减仓 |
| Trexquant投资Trexquant Investment LP |
| 0.04% | — | #51 | $627.6万 | 34.9万股 | $0 | 0股 | +34.9万股 | 新买入 |
