| 富达投资FMR LLC |
| 0.02% | 0.02% | #72 | $3.58亿 | 489.4万股 | $3.57亿 | 558.7万股 | -69.2万股-12.39% | 减仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #105 | $1.81亿 | 246.8万股 | $1.45亿 | 227.4万股 | +19.4万股+8.53% | 加仓 |
| RA资本管理RA CAPITAL MANAGEMENT, L.P. |
| 1.56% | 1.66% | #17 | $1.79亿 | 245.0万股 | $1.57亿 | 245.0万股 | 00.00% | 持仓不变 |
| 摩根大通JPMORGAN CHASE & CO |
| 0.01% | 0.01% | #84 | $1.40亿 | 187.6万股 | $8,335.9万 | 137.1万股 | +50.4万股+36.77% | 加仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.01% | 0.01% | #75 | $1.37亿 | 187.5万股 | $9,906.7万 | 154.9万股 | +32.6万股+21.04% | 加仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| 0.02% | 0.02% | #66 | $1.27亿 | 174.1万股 | $1.11亿 | 173.5万股 | +5,975股+0.34% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #100 | $1.21亿 | 164.9万股 | $1.09亿 | 169.8万股 | -4.9万股-2.91% | 减仓 |
| Vestal Point 资本Vestal Point Capital, LP |
| 2.65% | 1.25% | #10 | $1.13亿 | 155.0万股 | $4,475.8万 | 70.0万股 | +85.0万股+121.43% | 加仓 |
| Atlas Venture Life Science Advisors, LLC |
| 12.56% | 12.25% | #1 | $1.11亿 | 151.4万股 | $9,679.7万 | 151.4万股 | 00.00% | 持仓不变 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #117 | $1.00亿 | 136.9万股 | $8,794.5万 | 137.5万股 | -6,403股-0.47% | 减仓 |
| Frazier Life Sciences 管理Frazier Life Sciences Management, L.P. |
| 2.16% | 2.23% | #13 | $9,909.4万 | 135.5万股 | $8,662.9万 | 135.5万股 | 00.00% | 持仓不变 |
| TCG Crossover 管理TCG Crossover Management, LLC |
| 2.36% | 2.45% | #11 | $9,814.4万 | 134.2万股 | $8,579.9万 | 134.2万股 | 00.00% | 持仓不变 |
| BVF INC/IL |
| 2.16% | 2.59% | #14 | $8,437.5万 | 115.4万股 | $8,135.2万 | 127.2万股 | -11.9万股-9.33% | 减仓 |
| Woodline合伙人Woodline Partners LP |
| 0.22% | 0.23% | #34 | $7,008.9万 | 95.8万股 | $6,127.2万 | 95.8万股 | 00.00% | 持仓不变 |
| Siren, L.L.C. |
| 1.31% | 1.75% | #18 | $6,497.8万 | 88.8万股 | $6,319.8万 | 98.8万股 | -10.0万股-10.12% | 减仓 |
| Logos Global Management LP |
| 2.76% | 1.79% | #9 | $6,399.8万 | 87.5万股 | $3,580.6万 | 56.0万股 | +31.5万股+56.25% | 加仓 |
| Opaleye Management Inc. |
| 5.66% | 3.55% | #3 | $6,253.5万 | 85.5万股 | $2,691.9万 | 42.1万股 | +43.4万股+103.09% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #102 | $5,777.2万 | 79.0万股 | $4,759.5万 | 74.4万股 | +4.6万股+6.11% | 加仓 |
| Deerfield管理DEERFIELD MANAGEMENT COMPANY, L.P. |
| 0.5% | 0.5% | #26 | $4,805.3万 | 65.7万股 | $4,200.9万 | 65.7万股 | 00.00% | 持仓不变 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| 0.01% | 0.01% | #85 | $4,162.2万 | 56.9万股 | $2,521.2万 | 39.4万股 | +17.5万股+44.26% | 加仓 |
| Bellevue 集团Bellevue Group AG |
| 0.86% | 0.7% | #19 | $4,095.8万 | 56.0万股 | $2,936.9万 | 45.9万股 | +10.1万股+21.92% | 加仓 |
| Saturn V Capital Management LP |
| 5.5% | 5.21% | #4 | $3,837.9万 | 52.5万股 | $2,876.8万 | 45.0万股 | +7.5万股+16.63% | 加仓 |
| 停战资本ARMISTICE CAPITAL, LLC |
| 0.41% | 0.61% | #28 | $3,364.4万 | 46.0万股 | $3,427.2万 | 53.6万股 | -7.6万股-14.18% | 减仓 |
| 詹尼森联营JENNISON ASSOCIATES LLC |
| 0.02% | 0.03% | #68 | $3,214.6万 | 44.0万股 | $3,902.8万 | 61.0万股 | -17.1万股-27.99% | 减仓 |
| 安本标准投资Aberdeen Group plc |
| 0.04% | 0.04% | #52 | $3,204.8万 | 43.8万股 | $2,401.7万 | 37.6万股 | +6.3万股+16.66% | 加仓 |
| Palo Alto Investors LP |
| 4.45% | 3.93% | #6 | $3,047.3万 | 41.7万股 | $2,568.6万 | 40.2万股 | +1.5万股+3.72% | 加仓 |
| 暮色资产管理EVENTIDE ASSET MANAGEMENT, LLC |
| 0.39% | 0.42% | #29 | $2,893.8万 | 39.6万股 | $2,529.2万 | 39.6万股 | +79股+0.02% | 加仓 |
| 百达资产管理Pictet Asset Management Holding SA |
| 0.03% | 0.03% | #60 | $2,818.6万 | 38.5万股 | $2,474.5万 | 38.7万股 | -1,630股-0.42% | 减仓 |
| Assenagon资产管理Assenagon Asset Management S.A. |
| 0.04% | 0.05% | #57 | $2,809.7万 | 38.4万股 | $3,492.7万 | 54.6万股 | -16.2万股-29.67% | 减仓 |
| 卢米斯塞勒斯LOOMIS SAYLES & CO L P |
| 0.04% | 0.03% | #56 | $2,793.0万 | 38.2万股 | $2,028.3万 | 31.7万股 | +6.5万股+20.38% | 加仓 |
| Foresite Capital Management V, LLC |
| 7.55% | 8.83% | #2 | $2,735.9万 | 37.4万股 | $2,391.8万 | 37.4万股 | 00.00% | 持仓不变 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 0.49% | 1.35% | #27 | $2,615.0万 | 35.8万股 | $6,825.9万 | 106.8万股 | -71.0万股-66.51% | 减仓 |
| 贝克兄弟顾问BAKER BROS. ADVISORS LP |
| 0.13% | 0.13% | #38 | $2,557.4万 | 35.0万股 | $2,235.7万 | 35.0万股 | 00.00% | 持仓不变 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #138 | $2,062.1万 | 28.2万股 | $1,581.5万 | 24.7万股 | +3.5万股+13.99% | 加仓 |
| Octagon Capital Advisors LP |
| 1.78% | 1.91% | #15 | $1,974.8万 | 27.0万股 | $1,726.4万 | 27.0万股 | 00.00% | 持仓不变 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #116 | $1,938.1万 | 26.5万股 | $1,580.6万 | 24.7万股 | +1.8万股+7.20% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #112 | $1,882.5万 | 25.7万股 | $1,606.1万 | 25.1万股 | +6,187股+2.46% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #118 | $1,772.2万 | 24.2万股 | $838.4万 | 13.1万股 | +11.1万股+84.78% | 加仓 |
| Checkpoint Capital L.P. |
| 4.51% | 6.58% | #5 | $1,756.3万 | 24.0万股 | $1,832.9万 | 28.7万股 | -4.7万股-16.23% | 减仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #99 | $1,647.1万 | 22.5万股 | $1,390.3万 | 21.7万股 | +7,762股+3.57% | 加仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #114 | $1,497.4万 | 20.5万股 | $1,310.6万 | 20.5万股 | -241股-0.12% | 减仓 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| 0.01% | <0.01% | #88 | $1,350.9万 | 18.5万股 | $816.8万 | 12.8万股 | +5.7万股+44.59% | 加仓 |
| Catalio Capital Management, LP |
| 2.19% | 1.64% | #12 | $1,165.7万 | 15.9万股 | $786.3万 | 12.3万股 | +3.6万股+29.60% | 加仓 |
| Caption管理Caption Management, LLC |
| 0.05% | 0.11% | #49 | $1,097.1万 | 15.0万股 | $1,918.2万 | 30.0万股 | -15.0万股-50.00% | 减仓 |
| Sofinnova Investments, Inc. |
| 0.55% | 0.19% | #25 | $1,069.6万 | 14.6万股 | $500.8万 | 7.8万股 | +6.8万股+86.72% | 加仓 |
| Bain Capital Life Sciences Investors, LLC |
| 0.61% | 0.81% | #23 | $1,033.0万 | 14.1万股 | $903.1万 | 14.1万股 | 00.00% | 持仓不变 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| 0.01% | — | #86 | $1,000.2万 | 13.7万股 | $0 | 0股 | +13.7万股 | 新买入 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #156 | $988.2万 | 13.5万股 | $1,066.4万 | 16.7万股 | -3.2万股-18.99% | 减仓 |
| Alyeska投资集团Alyeska Investment Group, L.P. |
| 0.02% | 0.02% | #64 | $914.3万 | 12.5万股 | $799.3万 | 12.5万股 | 00.00% | 持仓不变 |
| Ensign Peak顾问Ensign Peak Advisors, Inc |
| 0.01% | 0.02% | #74 | $893.1万 | 12.2万股 | $1,224.4万 | 19.1万股 | -6.9万股-36.23% | 减仓 |
