| SB投资顾问(英国)SB INVESTMENT ADVISERS (UK) LTD |
| 6.81% | 3.59% | #6 | $5.22亿 | 2,790.5万股 | $2.78亿 | 2,790.5万股 | 00.00% | 持仓不变 |
| 富达投资FMR LLC |
| 0.02% | <0.01% | #80 | $3.76亿 | 2,011.0万股 | $3,677.0万 | 369.5万股 | +1,641.5万股+444.19% | 加仓 |
| Casdin Capital, LLC |
| 15.02% | 10.86% | #1 | $3.00亿 | 1,603.5万股 | $1.43亿 | 1,441.9万股 | +161.7万股+11.21% | 加仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #120 | $2.86亿 | 1,528.8万股 | $1.29亿 | 1,297.5万股 | +231.3万股+17.83% | 加仓 |
| 洞察顾问PERCEPTIVE ADVISORS LLC |
| 3.96% | 1.9% | #9 | $2.64亿 | 1,410.6万股 | $9,702.4万 | 975.1万股 | +435.5万股+44.66% | 加仓 |
| Commodore Capital LP |
| 13.37% | 9.79% | #2 | $2.25亿 | 1,200.0万股 | $1.69亿 | 1,700.0万股 | -500.0万股-29.41% | 减仓 |
| 道富集团STATE STREET CORP |
| 0.01% | <0.01% | #107 | $1.89亿 | 1,012.5万股 | $6,202.4万 | 623.4万股 | +389.2万股+62.43% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #128 | $1.68亿 | 896.4万股 | $7,350.5万 | 738.7万股 | +157.7万股+21.35% | 加仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.01% | <0.01% | #81 | $1.44亿 | 770.9万股 | $1,915.4万 | 192.5万股 | +578.4万股+300.45% | 加仓 |
| Nextech Invest Ltd. |
| 6.04% | 3.87% | #7 | $1.27亿 | 677.7万股 | $5,498.9万 | 552.7万股 | +125.0万股+22.62% | 加仓 |
| Bellevue 集团Bellevue Group AG |
| 2.44% | 1.85% | #12 | $1.16亿 | 618.6万股 | $7,756.3万 | 779.5万股 | -160.9万股-20.64% | 减仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #114 | $8,844.9万 | 472.7万股 | $3,493.8万 | 351.1万股 | +121.6万股+34.64% | 加仓 |
| TCG Crossover 管理TCG Crossover Management, LLC |
| 1.92% | 1.22% | #14 | $7,995.4万 | 427.3万股 | $4,252.0万 | 427.3万股 | 00.00% | 持仓不变 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #125 | $7,205.4万 | 385.1万股 | $920.9万 | 176.4万股 | +208.7万股+118.30% | 加仓 |
| Siren, L.L.C. |
| 1.38% | — | #16 | $6,829.2万 | 365.0万股 | $0 | 0股 | +365.0万股 | 新买入 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| 0.01% | <0.01% | #108 | $6,377.7万 | 340.9万股 | $2,529.2万 | 254.2万股 | +86.7万股+34.10% | 加仓 |
| Westfield资本管理WESTFIELD CAPITAL MANAGEMENT CO LP |
| 0.2% | — | #36 | $6,255.7万 | 334.3万股 | $0 | 0股 | +334.3万股 | 新买入 |
| Kynam Capital Management, LP |
| 3.41% | 0.87% | #10 | $6,174.3万 | 330.0万股 | $1,417.1万 | 142.4万股 | +187.6万股+131.70% | 加仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| 0.01% | 0.01% | #88 | $5,853.4万 | 312.8万股 | $2,924.8万 | 294.1万股 | +18.7万股+6.36% | 加仓 |
| Spruce Street Capital LP |
| 10.95% | 7.14% | #3 | $5,583.3万 | 298.4万股 | $2,969.2万 | 298.4万股 | 00.00% | 持仓不变 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #144 | $5,412.4万 | 289.3万股 | $1,854.2万 | 186.4万股 | +102.9万股+55.23% | 加仓 |
| 贝克兄弟顾问BAKER BROS. ADVISORS LP |
| 0.27% | 0.07% | #35 | $5,288.9万 | 282.7万股 | $1,154.3万 | 116.0万股 | +166.7万股+143.66% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #132 | $5,042.5万 | 269.5万股 | $1,928.0万 | 193.8万股 | +75.7万股+39.09% | 加仓 |
| MPM BioImpact LLC |
| 2.76% | 1.81% | #11 | $4,519.7万 | 241.6万股 | $2,347.8万 | 236.0万股 | +5.6万股+2.38% | 加仓 |
| 箭街资本ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
| 0.02% | <0.01% | #73 | $4,189.0万 | 223.9万股 | $664.9万 | 66.8万股 | +157.1万股+235.02% | 加仓 |
| 联博ALLIANCEBERNSTEIN L.P. |
| 0.01% | <0.01% | #83 | $4,075.1万 | 409.6万股 | $122.9万 | 14.5万股 | +395.0万股+2,719.67% | 加仓 |
| 百达资产管理Pictet Asset Management Holding SA |
| 0.04% | <0.01% | #61 | $3,922.0万 | 207.7万股 | $19.5万 | 2.0万股 | +205.8万股+10,502.78% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #119 | $3,654.9万 | 195.3万股 | $1,667.0万 | 167.5万股 | +27.8万股+16.60% | 加仓 |
| 普信投资管理T. Rowe Price Investment Management, Inc. |
| 0.02% | — | #65 | $3,583.8万 | 191.5万股 | $0 | 0股 | +191.5万股 | 新买入 |
| 富兰克林资源FRANKLIN RESOURCES INC |
| 0.01% | <0.01% | #99 | $3,474.3万 | 185.7万股 | $48.7万 | 4.9万股 | +180.8万股+3,696.20% | 加仓 |
| 极地资本控股Polar Capital Holdings Plc |
| 0.08% | — | #43 | $3,347.3万 | 178.9万股 | $0 | 0股 | +178.9万股 | 新买入 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.05% | 0.04% | #57 | $3,255.5万 | 174.0万股 | $2,577.1万 | 259.0万股 | -85.0万股-32.82% | 减仓 |
| Caption管理Caption Management, LLC |
| 0.13% | 0.07% | #37 | $2,833.8万 | 151.5万股 | $1,114.4万 | 112.0万股 | +39.5万股+35.23% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #127 | $2,808.0万 | 150.1万股 | $1,106.3万 | 111.2万股 | +38.9万股+34.98% | 加仓 |
| Elmind Capital, LP |
| 6.89% | 1.52% | #5 | $2,741.5万 | 146.5万股 | $534.3万 | 53.7万股 | +92.8万股+172.89% | 加仓 |
| PanAgora资产管理PANAGORA ASSET MANAGEMENT INC |
| 0.07% | 0.03% | #45 | $2,415.8万 | 129.1万股 | $814.0万 | 81.8万股 | +47.3万股+57.84% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #139 | $2,408.1万 | 128.7万股 | $201.4万 | 20.2万股 | +108.5万股+536.02% | 加仓 |
| AQR资本管理AQR CAPITAL MANAGEMENT LLC |
| 0.01% | 0.01% | #95 | $2,393.9万 | 127.9万股 | $1,283.6万 | 129.0万股 | -1.1万股-0.82% | 减仓 |
| Foresite Capital Management IV, LLC |
| 8.06% | 4.2% | #4 | $2,338.8万 | 125.0万股 | $995.0万 | 100.0万股 | +25.0万股+25.00% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| 0.01% | <0.01% | #111 | $2,290.1万 | 122.4万股 | $896.0万 | 90.1万股 | +32.3万股+35.92% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #142 | $2,048.7万 | 109.5万股 | $525.0万 | 52.8万股 | +56.7万股+107.54% | 加仓 |
| 第一信托顾问FIRST TRUST ADVISORS LP |
| 0.01% | — | #85 | $2,011.6万 | 107.5万股 | $0 | 0股 | +107.5万股 | 新买入 |
| Affinity Asset Advisors, LLC |
| 0.89% | 0.21% | #18 | $1,964.6万 | 105.0万股 | $398.0万 | 40.0万股 | +65.0万股+162.50% | 加仓 |
| Frazier Life Sciences 管理Frazier Life Sciences Management, L.P. |
| 0.41% | — | #28 | $1,900.4万 | 101.6万股 | $0 | 0股 | +101.6万股 | 新买入 |
| Squadron Capital Management LLC |
| 5.63% | 3% | #8 | $1,814.9万 | 97.0万股 | $818.4万 | 82.3万股 | +14.8万股+17.93% | 加仓 |
| Connor Clark & Lunn投资管理Connor, Clark & Lunn Investment Management Ltd. |
| 0.03% | 0.02% | #62 | $1,799.3万 | 96.2万股 | $832.9万 | 83.7万股 | +12.5万股+14.89% | 加仓 |
| Woodline合伙人Woodline Partners LP |
| 0.05% | 0.03% | #54 | $1,739.5万 | 93.0万股 | $675.9万 | 67.9万股 | +25.0万股+36.85% | 加仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #184 | $1,596.6万 | 80.2万股 | $605.4万 | 64.8万股 | +15.4万股+23.80% | 加仓 |
| Alphabet公司Alphabet Inc. |
| 0.36% | 0.39% | #30 | $1,556.4万 | 156.4万股 | $1,556.4万 | 156.4万股 | 00.00% | 持仓不变 |
| Timothy G. Youngquist 2020 Irrevocable Trust |
| 0.64% | — | #19 | $1,499.5万 | 80.1万股 | $0 | 0股 | +80.1万股 | 新买入 |
