| 富达投资FMR LLC |
| 0.02% | 0.02% | #65 | $4.33亿 | 1,260.9万股 | $2.97亿 | 1,245.2万股 | +15.7万股+1.26% | 加仓 |
| 法伦资本FARALLON CAPITAL MANAGEMENT, L.L.C. |
| 1.62% | 1.38% | #9 | $3.51亿 | 1,023.6万股 | $2.42亿 | 1,013.5万股 | +10.2万股+1.00% | 加仓 |
| ARK投资管理ARK Investment Management LLC |
| 2.27% | 2.25% | #7 | $3.51亿 | 1,023.5万股 | $2.89亿 | 1,213.3万股 | -189.9万股-15.65% | 减仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #109 | $3.09亿 | 899.8万股 | $2.02亿 | 848.8万股 | +51.0万股+6.01% | 加仓 |
| 道富集团STATE STREET CORP |
| 0.01% | <0.01% | #106 | $2.00亿 | 582.7万股 | $1.36亿 | 569.9万股 | +12.8万股+2.24% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.01% | 0.01% | #87 | $1.69亿 | 492.1万股 | $1.09亿 | 457.1万股 | +35.0万股+7.67% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #129 | $1.58亿 | 459.9万股 | $1.04亿 | 437.7万股 | +22.2万股+5.07% | 加仓 |
| ARCH Venture Management, LLC |
| 14.16% | 15.98% | #1 | $1.56亿 | 454.0万股 | $1.08亿 | 454.0万股 | 00.00% | 持仓不变 |
| 三井住友信托集团Sumitomo Mitsui Trust Group, Inc. |
| 0.07% | 0.06% | #42 | $1.19亿 | 345.5万股 | $9,116.4万 | 382.6万股 | -37.1万股-9.69% | 减仓 |
| Amova资产管理Amova Asset Management Americas, Inc. |
| 1.53% | 1.29% | #10 | $1.19亿 | 345.5万股 | $9,116.4万 | 382.6万股 | -37.1万股-9.69% | 减仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.01% | 0.01% | #74 | $1.17亿 | 341.5万股 | $6,465.8万 | 271.3万股 | +70.2万股+25.87% | 加仓 |
| Kynam Capital Management, LP |
| 5.39% | 5.41% | #2 | $9,749.6万 | 284.1万股 | $8,774.6万 | 368.2万股 | -84.1万股-22.85% | 减仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #108 | $8,914.4万 | 259.7万股 | $5,764.7万 | 241.9万股 | +17.8万股+7.37% | 加仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| 0.01% | 0.01% | #70 | $7,639.7万 | 222.6万股 | $5,132.7万 | 215.5万股 | +7.1万股+3.31% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #125 | $6,695.7万 | 195.1万股 | $1,564.8万 | 64.5万股 | +130.6万股+202.59% | 加仓 |
| Contrarius Group Holdings Ltd |
| 2.55% | 0.72% | #5 | $5,541.1万 | 161.5万股 | $1,271.2万 | 53.3万股 | +108.1万股+202.66% | 加仓 |
| 瑞银资产管理(美洲)UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
| 0.01% | 0.01% | #82 | $5,325.7万 | 155.2万股 | $3,940.8万 | 165.4万股 | -10.2万股-6.16% | 减仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| 0.03% | 0.02% | #54 | $4,764.4万 | 138.8万股 | $2,885.5万 | 121.1万股 | +17.7万股+14.65% | 加仓 |
| Casdin Capital, LLC |
| 2.32% | 2.44% | #6 | $4,633.2万 | 135.0万股 | $3,217.1万 | 135.0万股 | 00.00% | 持仓不变 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #120 | $4,496.1万 | 131.0万股 | $2,396.7万 | 100.6万股 | +30.4万股+30.26% | 加仓 |
| Redmile Group, LLC |
| 2.68% | 1.95% | #4 | $3,995.7万 | 116.4万股 | $2,949.3万 | 123.8万股 | -7.3万股-5.93% | 减仓 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| 0.02% | 0.01% | #68 | $3,665.0万 | 106.8万股 | $1,669.6万 | 70.1万股 | +36.7万股+52.41% | 加仓 |
| 深轨资本Deep Track Capital, LP |
| 0.5% | 0.32% | #15 | $3,432.0万 | 100.0万股 | $1,955.9万 | 82.1万股 | +17.9万股+21.84% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #122 | $3,203.7万 | 93.3万股 | $1,967.4万 | 82.6万股 | +10.8万股+13.07% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #116 | $3,040.4万 | 88.6万股 | $1,926.5万 | 80.8万股 | +7.7万股+9.58% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #156 | $2,473.3万 | 72.1万股 | $1,282.7万 | 53.8万股 | +18.2万股+33.88% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| 0.01% | <0.01% | #107 | $2,439.2万 | 71.1万股 | $1,632.0万 | 68.5万股 | +2.6万股+3.77% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #141 | $1,972.8万 | 57.5万股 | $1,968.5万 | 82.6万股 | -25.1万股-30.42% | 减仓 |
| RTW投资RTW INVESTMENTS, LP |
| 0.17% | 0.14% | #28 | $1,957.6万 | 57.0万股 | $1,359.2万 | 57.0万股 | 00.00% | 持仓不变 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #171 | $1,814.1万 | 51.5万股 | $1,207.5万 | 55.1万股 | -3.7万股-6.64% | 减仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| 0.01% | <0.01% | #72 | $1,643.9万 | 47.9万股 | $331.8万 | 13.9万股 | +34.0万股+243.99% | 加仓 |
| Elmind Capital, LP |
| 4.11% | 3.22% | #3 | $1,634.8万 | 47.6万股 | $1,135.1万 | 47.6万股 | 00.00% | 持仓不变 |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd |
| 1% | 0.88% | #14 | $1,564.8万 | 45.6万股 | $1,163.9万 | 48.8万股 | -3.2万股-6.65% | 减仓 |
| 木星资产管理JUPITER ASSET MANAGEMENT LTD |
| 0.08% | <0.01% | #41 | $1,529.7万 | 44.6万股 | $57.3万 | 2.4万股 | +42.2万股+1,752.53% | 加仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| 0.02% | 0.02% | #59 | $1,527.2万 | 44.5万股 | $1,223.9万 | 51.4万股 | -6.9万股-13.35% | 减仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #163 | $1,371.4万 | 40.0万股 | $1,326.4万 | 55.7万股 | -15.7万股-28.21% | 减仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #148 | $1,245.1万 | 36.3万股 | $820.9万 | 34.4万股 | +1.8万股+5.32% | 加仓 |
| Foresite Capital Management VI LLC |
| 1.76% | — | #8 | $1,132.6万 | 33.0万股 | $0 | 0股 | +33.0万股 | 新买入 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #162 | $1,083.5万 | 31.6万股 | $1,920.9万 | 80.6万股 | -49.0万股-60.83% | 减仓 |
| 百利吉福德BAILLIE GIFFORD & CO |
| 0.01% | 0.01% | #80 | $1,078.4万 | 31.4万股 | $919.6万 | 38.6万股 | -7.2万股-18.57% | 减仓 |
| Integral Health 资产管理Integral Health Asset Management, LLC |
| 0.41% | 0.34% | #19 | $1,029.6万 | 30.0万股 | $714.9万 | 30.0万股 | 00.00% | 持仓不变 |
| 箭街资本ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
| <0.01% | — | #110 | $1,016.9万 | 29.6万股 | $0 | 0股 | +29.6万股 | 新买入 |
| 百达资产管理Pictet Asset Management Holding SA |
| 0.01% | 0.01% | #84 | $875.7万 | 25.1万股 | $654.4万 | 29.8万股 | -4.7万股-15.70% | 减仓 |
| 纽文Nuveen, LLC |
| <0.01% | <0.01% | #149 | $841.8万 | 24.5万股 | $554.3万 | 23.3万股 | +1.3万股+5.45% | 加仓 |
| Alphabet公司Alphabet Inc. |
| 0.18% | 0.19% | #25 | $766.4万 | 32.2万股 | $766.4万 | 32.2万股 | 00.00% | 持仓不变 |
| 美国世纪投资AMERICAN CENTURY COMPANIES INC |
| <0.01% | <0.01% | #135 | $702.5万 | 20.5万股 | $401.9万 | 16.9万股 | +3.6万股+21.36% | 加仓 |
| 景顺Invesco Ltd. |
| <0.01% | <0.01% | #190 | $666.4万 | 19.4万股 | $524.2万 | 22.0万股 | -2.6万股-11.72% | 减仓 |
| Qube研究科技Qube Research & Technologies Ltd |
| 0.01% | 0.03% | #102 | $666.1万 | 19.4万股 | $2,585.0万 | 108.5万股 | -89.1万股-82.11% | 减仓 |
| 富国银行WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #164 | $650.0万 | 18.9万股 | $315.1万 | 13.2万股 | +5.7万股+43.21% | 加仓 |
| 麦肯齐金融MACKENZIE FINANCIAL CORP |
| 0.01% | — | #103 | $636.6万 | 18.5万股 | $0 | 0股 | +18.5万股 | 新买入 |
