| TCG Crossover 管理TCG Crossover Management, LLC |
| 19.24% | 20.65% | #1 | $8.01亿 | 600.8万股 | $7.22亿 | 648.1万股 | -47.3万股-7.30% | 减仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| 0.05% | 0.02% | #126 | $6.19亿 | 464.8万股 | $1.43亿 | 128.5万股 | +336.3万股+261.77% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| 0.06% | 0.02% | #118 | $5.66亿 | 424.4万股 | $1.49亿 | 133.9万股 | +290.5万股+216.93% | 加仓 |
| Helikon 投资Helikon Investments Ltd |
| 11.1% | 4.26% | #11 | $3.71亿 | 278.7万股 | $1.13亿 | 101.3万股 | +177.4万股+175.05% | 加仓 |
| Darwin Global Management, Ltd. |
| 9.26% | 9.34% | #16 | $3.48亿 | 362.2万股 | $3.52亿 | 346.9万股 | +15.3万股+4.41% | 加仓 |
| Vestal Point 资本Vestal Point Capital, LP |
| 7.32% | 4.67% | #19 | $3.13亿 | 234.9万股 | $1.67亿 | 150.0万股 | +84.9万股+56.63% | 加仓 |
| 木星资产管理Jupiter Topco LLC |
| 0.1% | — | #107 | $2.55亿 | 191.4万股 | $0 | 0股 | +191.4万股 | 新买入 |
| 瑞银集团UBS Group AG |
| 0.03% | 0.08% | #140 | $2.48亿 | 186.1万股 | $5.06亿 | 454.7万股 | -268.7万股-59.08% | 减仓 |
| ADAR1 Capital Management, LLC |
| 11.36% | 9.43% | #9 | $2.46亿 | 184.9万股 | $1.60亿 | 143.8万股 | +41.1万股+28.59% | 加仓 |
| Caligan Partners LP |
| 9.77% | 10.83% | #14 | $2.08亿 | 155.8万股 | $1.63亿 | 146.2万股 | +9.6万股+6.57% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| 0.01% | 0.01% | #175 | $1.91亿 | 143.2万股 | $1.25亿 | 147.1万股 | -3.9万股-2.62% | 减仓 |
| Westfield资本管理WESTFIELD CAPITAL MANAGEMENT CO LP |
| 0.57% | 0.62% | #72 | $1.75亿 | 131.0万股 | $1.47亿 | 132.3万股 | -1.3万股-0.99% | 减仓 |
| RA资本管理RA CAPITAL MANAGEMENT, L.P. |
| 1.31% | — | #55 | $1.51亿 | 113.3万股 | $0 | 0股 | +113.3万股 | 新买入 |
| 挪威央行投资管理NORGES BANK |
| 0.01% | — | #163 | $1.47亿 | 110.0万股 | $0 | 0股 | +110.0万股 | 新买入 |
| Logos Global Management LP |
| 5.87% | 3.75% | #23 | $1.36亿 | 102.4万股 | $7,516.1万 | 67.5万股 | +34.9万股+51.70% | 加仓 |
| Octagon Capital Advisors LP |
| 11.89% | 8.34% | #8 | $1.32亿 | 99.3万股 | $7,538.4万 | 67.7万股 | +31.6万股+46.68% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| 0.01% | 0.01% | #179 | $1.29亿 | 97.1万股 | $8,192.3万 | 73.6万股 | +23.6万股+32.04% | 加仓 |
| Ikarian Capital, LLC |
| 12.96% | 3.16% | #5 | $1.22亿 | 92.0万股 | $3,889.2万 | 35.1万股 | +56.9万股+162.08% | 加仓 |
| Eversept Partners, LP |
| 6.32% | 5.49% | #21 | $1.22亿 | 91.4万股 | $1.04亿 | 93.4万股 | -2.1万股-2.20% | 减仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| 0.01% | <0.01% | #177 | $1.06亿 | 79.3万股 | $3,883.9万 | 34.9万股 | +44.4万股+127.27% | 加仓 |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. |
| 5.59% | 7.23% | #24 | $1.02亿 | 76.5万股 | $8,528.5万 | 76.6万股 | -583股-0.08% | 减仓 |
| DIADEMA PARTNERS LP |
| 12.56% | 5.19% | #7 | $1.02亿 | 76.5万股 | $3,048.7万 | 27.6万股 | +48.9万股+177.32% | 加仓 |
| 布斯湾基金管理BOOTHBAY FUND MANAGEMENT, LLC |
| 1.33% | 0.81% | #54 | $9,974.1万 | 74.8万股 | $6,227.4万 | 55.9万股 | +18.9万股+33.83% | 加仓 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 1.88% | 1.03% | #46 | $9,948.2万 | 74.7万股 | $5,185.6万 | 46.6万股 | +28.1万股+60.30% | 加仓 |
| LMR合伙人LMR Partners LLP |
| 0.36% | 0.06% | #82 | $9,483.5万 | 71.2万股 | $2,536.0万 | 22.8万股 | +48.4万股+212.47% | 加仓 |
| Cormorant Asset Management, LP |
| 4.57% | 4.25% | #30 | $8,995.1万 | 67.5万股 | $8,462.6万 | 76.0万股 | -8.5万股-11.18% | 减仓 |
| ExodusPoint资本ExodusPoint Capital Management, LP |
| 0.54% | — | #73 | $8,387.5万 | 62.9万股 | $0 | 0股 | +62.9万股 | 新买入 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| 0.1% | 0.03% | #108 | $8,321.3万 | 62.4万股 | $2,379.4万 | 21.4万股 | +41.1万股+192.22% | 加仓 |
| Boxer Capital Management, LLC |
| 6.07% | 2.92% | #22 | $8,062.2万 | 60.5万股 | $2,227.0万 | 20.0万股 | +40.5万股+202.50% | 加仓 |
| GREAT POINT PARTNERS LLC |
| 15.22% | — | #2 | $8,053.1万 | 60.4万股 | $0 | 0股 | +60.4万股 | 新买入 |
| Siren, L.L.C. |
| 1.55% | — | #50 | $7,675.8万 | 57.6万股 | $0 | 0股 | +57.6万股 | 新买入 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #239 | $7,649.9万 | 57.4万股 | $4,758.4万 | 42.7万股 | +14.7万股+34.34% | 加仓 |
| 峰会合伙人公共资产SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC |
| 1.34% | — | #53 | $7,595.8万 | 57.0万股 | $0 | 0股 | +57.0万股 | 新买入 |
| 都铎投资TUDOR INVESTMENT CORP ET AL |
| 0.1% | 0.02% | #110 | $6,995.3万 | 52.5万股 | $1,295.1万 | 11.6万股 | +40.9万股+351.32% | 加仓 |
| 安本标准投资Aberdeen Group plc |
| 0.1% | 0.08% | #109 | $6,956.5万 | 52.2万股 | $4,801.9万 | 43.1万股 | +9.1万股+21.05% | 加仓 |
| Saturn V Capital Management LP |
| 9.91% | 10.94% | #13 | $6,914.4万 | 51.9万股 | $6,042.9万 | 54.3万股 | -2.4万股-4.39% | 减仓 |
| Artia Global Partners LP |
| 12.7% | 13.39% | #6 | $6,882.2万 | 51.6万股 | $6,689.3万 | 60.1万股 | -8.4万股-14.03% | 减仓 |
| 两海资本Two Seas Capital LP |
| 1.35% | — | #52 | $6,809.5万 | 51.1万股 | $0 | 0股 | +51.1万股 | 新买入 |
| Ensign Peak顾问Ensign Peak Advisors, Inc |
| 0.11% | 0.13% | #105 | $6,722.6万 | 50.4万股 | $7,035.5万 | 63.2万股 | -12.7万股-20.16% | 减仓 |
| 百达资产管理Pictet Asset Management Holding SA |
| 0.06% | 0.01% | #120 | $6,557.3万 | 49.2万股 | $1,120.2万 | 10.4万股 | +38.9万股+375.22% | 加仓 |
| First Turn Management, LLC |
| 6.98% | 5.8% | #20 | $6,528.3万 | 49.0万股 | $5,187.5万 | 46.6万股 | +2.4万股+5.16% | 加仓 |
| Holocene顾问Holocene Advisors, LP |
| 0.13% | 0.07% | #101 | $5,579.0万 | 41.9万股 | $2,880.1万 | 25.9万股 | +16.0万股+61.86% | 加仓 |
| Vivo Capital, LLC |
| 5.05% | 2.22% | #28 | $5,528.9万 | 41.5万股 | $2,667.3万 | 24.0万股 | +17.5万股+73.21% | 加仓 |
| 暮色资产管理EVENTIDE ASSET MANAGEMENT, LLC |
| 0.7% | 0.59% | #64 | $5,262.5万 | 39.5万股 | $3,569.4万 | 32.1万股 | +7.4万股+23.20% | 加仓 |
| MPM BioImpact LLC |
| 2.73% | 0.92% | #36 | $4,482.2万 | 33.6万股 | $1,194.4万 | 10.7万股 | +22.9万股+213.56% | 加仓 |
| Kite Lake Capital Management (UK) LLP |
| 15.18% | 11.58% | #3 | $4,401.6万 | 33.0万股 | $1,444.2万 | 13.0万股 | +20.1万股+154.66% | 加仓 |
| Affinity Asset Advisors, LLC |
| 1.99% | 2.33% | #45 | $4,397.6万 | 33.0万股 | $4,509.7万 | 40.5万股 | -7.5万股-18.52% | 减仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| 0.01% | 0.03% | #164 | $4,099.6万 | 30.8万股 | $6,915.9万 | 62.1万股 | -31.3万股-50.47% | 减仓 |
| Melqart Asset Management (UK) Ltd |
| 3.9% | — | #32 | $4,094.4万 | 30.7万股 | $0 | 0股 | +30.7万股 | 新买入 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | 0.01% | #201 | $4,002.7万 | 30.0万股 | $7,701.8万 | 69.2万股 | -39.1万股-56.57% | 减仓 |
