| Rosalind Advisors, Inc. |
| 0.65% | 2.56% | #2 | $2.7M | 3.9M | $6.4M | 3.9M | 00.00% | Unchanged |
| Aberdeen Group plc |
| <0.01% | 0.01% | #11 | $2.6M | 3.7M | $5.2M | 3.2M | +525,000+16.54% | Add |
| Nantahala Capital Management, LLC |
| 0.08% | 0.2% | #4 | $2.4M | 3.4M | $5.5M | 3.4M | 00.00% | Unchanged |
| ORBIMED ADVISORS LLC |
| 0.04% | 0.1% | #6 | $2.2M | 3.1M | $5.1M | 3.1M | 00.00% | Unchanged |
| Parkman Healthcare Partners LLC |
| 0.17% | 0.41% | #3 | $1.7M | 2.4M | $3.9M | 2.4M | 00.00% | Unchanged |
| MARSHALL WACE, LLP |
| <0.01% | <0.01% | #13 | $1.3M | 1.9M | $3.0M | 1.9M | 00.00% | Unchanged |
| Soleus Capital Management, L.P. |
| 0.03% | 0.07% | #7 | $732,100 | 1.0M | $1.7M | 1.0M | 00.00% | Unchanged |
| PURA VIDA INVESTMENTS, LLC |
| 0.85% | 4.94% | #1 | $315,407 | 450,517 | $734,343 | 450,517 | 00.00% | Unchanged |
| INGALLS & SNYDER LLC |
| 0.01% | 0.02% | #9 | $258,197 | 368,800 | $618,000 | 379,300 | -10,500-2.77% | Reduce |
| Affiance Financial, LLC |
| 0.03% | 0.07% | #8 | $175,284 | 250,370 | $408,103 | 250,370 | 00.00% | Unchanged |
| Velan Capital Investment Management LP |
| 0.06% | 2.14% | #5 | $103,711 | 148,138 | $3.4M | 2.1M | -2.0M-92.94% | Reduce |
| BlackRock, Inc. |
| <0.01% | <0.01% | #30 | $86,108 | 122,993 | $131,132 | 80,449 | +42,544+52.88% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #22 | $78,994 | 112,832 | $28,703 | 17,609 | +95,223+540.76% | Add |
| Creative Planning |
| <0.01% | <0.01% | #24 | $76,286 | 108,964 | $32,134 | 19,714 | +89,250+452.72% | Add |
| Schonfeld Strategic Advisors LLC |
| <0.01% | — | #20 | $69,502 | 99,275 | $0 | 0 | +99,275 | New Buy |
| HRT FINANCIAL LP |
| <0.01% | — | #23 | $41,834 | 59,754 | $0 | 0 | +59,754 | New Buy |
| XTX Topco Ltd |
| <0.01% | <0.01% | #15 | $34,325 | 49,029 | $20,144 | 12,358 | +36,671+296.74% | Add |
| Centiva Capital, LP |
| <0.01% | <0.01% | #19 | $30,891 | 44,123 | $40,369 | 24,766 | +19,357+78.16% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #27 | $26,378 | 37,677 | $183,249 | 112,423 | -74,746-66.49% | Reduce |
| COURIER CAPITAL LLC |
| <0.01% | <0.01% | #12 | $21,003 | 30,000 | $48,900 | 30,000 | 00.00% | Unchanged |
| Mesirow Financial Investment Management, Inc. |
| <0.01% | <0.01% | #17 | $21,003 | 30,000 | $48,900 | 30,000 | 00.00% | Unchanged |
| MORGAN STANLEY |
| <0.01% | <0.01% | #33 | $19,863 | 28,371 | $207,286 | 86,011 | -57,640-67.01% | Reduce |
| VESTIA PERSONAL WEALTH ADVISORS |
| 0.01% | 0.02% | #10 | $17,100 | 24,425 | $39,812 | 24,425 | 00.00% | Unchanged |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | — | #31 | $14,418 | 20,594 | $0 | 0 | +20,594 | New Buy |
| Cambridge Investment Research Advisors, Inc. |
| <0.01% | — | #25 | $14,118 | 20,166 | $0 | 0 | +20,166 | New Buy |
| LPL Financial LLC |
| <0.01% | — | #29 | $13,037 | 18,621 | $0 | 0 | +18,621 | New Buy |
| OSAIC HOLDINGS, INC. |
| <0.01% | <0.01% | #26 | $11,165 | 15,952 | $17,036 | 10,452 | +5,500+52.62% | Add |
| Avestar Capital, LLC |
| <0.01% | <0.01% | #14 | $10,502 | 15,000 | $24,450 | 15,000 | 00.00% | Unchanged |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #32 | $9,521 | 13,600 | $107,173 | 65,750 | -52,150-79.32% | Reduce |
| Pallas Capital Advisors LLC |
| <0.01% | <0.01% | #21 | $7,701 | 11,000 | $21,190 | 13,000 | -2,000-15.38% | Reduce |
| McKinley Carter Wealth Services, Inc. |
| <0.01% | <0.01% | #16 | $7,001 | 10,000 | $16,300 | 10,000 | 00.00% | Unchanged |
| AdvisorNet Financial, Inc |
| <0.01% | <0.01% | #18 | $6,149 | 8,783 | $14,316 | 8,783 | 00.00% | Unchanged |
| UBS Group AG |
| <0.01% | <0.01% | #34 | $3,720 | 5,314 | $3,420 | 2,098 | +3,216+153.29% | Add |
| Farther Finance Advisors, LLC |
| <0.01% | <0.01% | #28 | $700 | 1,000 | $1,570 | 1,000 | 00.00% | Unchanged |
| SIMPLEX TRADING, LLC |
| <0.01% | <0.01% | #35 | $521 | 745 | $982 | 603 | +142+23.55% | Add |
| CITIGROUP INC |
| <0.01% | — | #37 | $1 | 1 | $0 | 0 | +1 | New Buy |
| Caitong International Asset Management Co., Ltd |
| <0.01% | — | #36 | $1 | 1 | $0 | 0 | +1 | New Buy |
