| DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.01% | 0.02% | #4 | $1.8M | 166,713 | $2.9M | 166,713 | 00.00% | Unchanged |
| Jupiter Topco LLC |
| <0.01% | — | #6 | $1.5M | 140,000 | $0 | 0 | +140,000 | New Buy |
| Logos Global Management LP |
| 0.06% | 0.12% | #2 | $1.4M | 130,000 | $2.4M | 140,000 | -10,000-7.14% | Reduce |
| RA CAPITAL MANAGEMENT, L.P. |
| 0.01% | 0.01% | #5 | $670,318 | 62,124 | $1.2M | 70,000 | -7,876-11.25% | Reduce |
| BALYASNY ASSET MANAGEMENT L.P. |
| <0.01% | <0.01% | #7 | $443,577 | 41,110 | $717,164 | 41,169 | -59-0.14% | Reduce |
| MORGAN STANLEY |
| <0.01% | — | #15 | $294,265 | 27,272 | $0 | 0 | +27,272 | New Buy |
| Opaleye Management Inc. |
| 0.02% | — | #3 | $221,195 | 20,500 | $0 | 0 | +20,500 | New Buy |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #16 | $209,244 | 19,382 | $322,474 | 18,502 | +880+4.76% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #18 | $204,050 | 18,911 | $330,614 | 18,979 | -68-0.36% | Reduce |
| Miller Financial Services LLC |
| 0.13% | 0.24% | #1 | $161,850 | 15,000 | $219,492 | 12,600 | +2,400+19.05% | Add |
| LPL Financial LLC |
| <0.01% | <0.01% | #11 | $135,436 | 12,552 | $218,708 | 12,555 | -3-0.02% | Reduce |
| Woodline Partners LP |
| <0.01% | — | #8 | $121,323 | 11,244 | $0 | 0 | +11,244 | New Buy |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #14 | $95,405 | 8,842 | $152,843 | 8,774 | +68+0.78% | Add |
| BlackRock, Inc. |
| <0.01% | — | #22 | $60,985 | 5,652 | $0 | 0 | +5,652 | New Buy |
| UBS Group AG |
| <0.01% | <0.01% | #19 | $32,219 | 2,986 | $57,991 | 3,329 | -343-10.30% | Reduce |
| Vanguard Global Advisers, LLC |
| <0.01% | <0.01% | #17 | $13,488 | 1,250 | $21,775 | 1,250 | 00.00% | Unchanged |
| Tower Research Capital LLC (TRC) |
| <0.01% | <0.01% | #10 | $6,398 | 593 | $5,888 | 338 | +255+75.44% | Add |
| OSAIC HOLDINGS, INC. |
| <0.01% | <0.01% | #20 | $1,832 | 170 | $2,941 | 169 | +1+0.59% | Add |
| JONES FINANCIAL COMPANIES LLLP |
| <0.01% | <0.01% | #23 | $1,773 | 155 | $2,999 | 150 | +5+3.33% | Add |
| US BANCORP \DE\ |
| <0.01% | <0.01% | #21 | $1,349 | 125 | $2,178 | 125 | 00.00% | Unchanged |
| SBI Securities Co., Ltd. |
| <0.01% | <0.01% | #12 | $1,155 | 107 | $226 | 13 | +94+723.08% | Add |
| Forum Finance Group S.A. |
| <0.01% | <0.01% | #9 | $993 | 92 | $1,603 | 92 | 00.00% | Unchanged |
| WEST PACES ADVISORS INC. |
| <0.01% | — | #13 | $129 | 12 | $0 | 0 | +12 | New Buy |
| BARCLAYS PLC |
| <0.01% | — | #24 | $108 | 10 | $0 | 0 | +10 | New Buy |
| WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #25 | $43 | 4 | $139 | 8 | -4-50.00% | Reduce |
