| Decheng Capital LLC |
| 3.08% | 2.23% | #1 | $22.6M | 3.9M | $14.8M | 3.9M | 00.00% | Unchanged |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #18 | $7.7M | 1.3M | $4.9M | 1.3M | +46,589+3.60% | Add |
| Laurion Capital Management LP |
| 0.15% | 0.17% | #2 | $6.0M | 1.0M | $3.9M | 1.0M | 00.00% | Unchanged |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #37 | $3.2M | 562,877 | $2.1M | 554,101 | +8,776+1.58% | Add |
| AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #17 | $2.8M | 480,249 | $507,046 | 134,495 | +345,754+257.08% | Add |
| EcoR1 Capital, LLC |
| 0.12% | — | #3 | $2.4M | 410,894 | $0 | 0 | +410,894 | New Buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| <0.01% | <0.01% | #10 | $1.7M | 300,000 | $1.1M | 300,000 | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #50 | $1.1M | 187,045 | $3.0M | 792,571 | -605,526-76.40% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #44 | $863,529 | 149,844 | $1.2M | 309,449 | -159,605-51.58% | Reduce |
| CANTOR FITZGERALD, L. P. |
| 0.01% | <0.01% | #6 | $671,512 | 116,582 | $251,391 | 66,682 | +49,900+74.83% | Add |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #21 | $624,252 | 108,377 | $615,848 | 163,355 | -54,978-33.66% | Reduce |
| RAYMOND JAMES FINANCIAL INC |
| <0.01% | <0.01% | #30 | $456,676 | 79,284 | $41,055 | 10,890 | +68,394+628.04% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #32 | $432,991 | 75,172 | $313,702 | 83,210 | -8,038-9.66% | Reduce |
| Woodline Partners LP |
| <0.01% | <0.01% | #13 | $417,191 | 72,429 | $273,057 | 72,429 | 00.00% | Unchanged |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #27 | $402,900 | 69,948 | $370,719 | 98,334 | -28,386-28.87% | Reduce |
| STATE STREET CORP |
| <0.01% | <0.01% | #53 | $341,412 | 59,273 | $751,444 | 199,322 | -140,049-70.26% | Reduce |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #47 | $263,024 | 45,664 | $75,400 | 20,000 | +25,664+128.32% | Add |
| J. Goldman & Co LP |
| 0.01% | — | #7 | $233,280 | 40,500 | $0 | 0 | +40,500 | New Buy |
| IEQ CAPITAL, LLC |
| <0.01% | <0.01% | #16 | $221,080 | 38,382 | $62,148 | 16,485 | +21,897+132.83% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #46 | $205,281 | 35,639 | $595,238 | 157,888 | -122,249-77.43% | Reduce |
| MORGAN STANLEY |
| <0.01% | <0.01% | #55 | $173,820 | 30,177 | $909,860 | 68,462 | -38,285-55.92% | Reduce |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #49 | $161,741 | 28,080 | $334,019 | 88,599 | -60,519-68.31% | Reduce |
| CITIGROUP INC |
| <0.01% | <0.01% | #42 | $151,482 | 26,299 | $174,419 | 46,265 | -19,966-43.16% | Reduce |
| Cresset Asset Management, LLC |
| <0.01% | <0.01% | #20 | $138,430 | 24,033 | $163,086 | 43,259 | -19,226-44.44% | Reduce |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | — | #52 | $138,384 | 24,025 | $0 | 0 | +24,025 | New Buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #9 | $138,240 | 24,000 | $101,790 | 27,000 | -3,000-11.11% | Reduce |
| Point72 Asset Management, L.P. |
| <0.01% | — | #26 | $131,743 | 22,872 | $0 | 0 | +22,872 | New Buy |
| Mariner, LLC |
| <0.01% | — | #29 | $125,408 | 21,784 | $0 | 0 | +21,784 | New Buy |
| SMITH, MOORE & CO. |
| 0.01% | — | #5 | $115,200 | 20,000 | $0 | 0 | +20,000 | New Buy |
| XTX Topco Ltd |
| <0.01% | <0.01% | #11 | $114,555 | 19,888 | $75,080 | 19,915 | -27-0.14% | Reduce |
| MARSHALL WACE, LLP |
| <0.01% | — | #33 | $109,879 | 19,076 | $0 | 0 | +19,076 | New Buy |
| FMR LLC |
| <0.01% | <0.01% | #63 | $108,887 | 18,904 | $33,772 | 8,958 | +9,946+111.03% | Add |
| SIMPLEX TRADING, LLC |
| <0.01% | <0.01% | #40 | $91,681 | 15,917 | $15,996 | 4,243 | +11,674+275.14% | Add |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC |
| <0.01% | — | #28 | $79,298 | 10,434 | $0 | 0 | +10,434 | New Buy |
| PRELUDE CAPITAL MANAGEMENT, LLC |
| <0.01% | 0.01% | #8 | $71,574 | 12,426 | $115,501 | 30,637 | -18,211-59.44% | Reduce |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #60 | $70,508 | 12,241 | $73,153 | 19,404 | -7,163-36.92% | Reduce |
| MERCER GLOBAL ADVISORS INC /ADV |
| <0.01% | — | #35 | $66,033 | 11,464 | $0 | 0 | +11,464 | New Buy |
| Cerity Partners LLC |
| <0.01% | — | #36 | $62,042 | 10,771 | $0 | 0 | +10,771 | New Buy |
| Abel Hall, LLC |
| 0.01% | — | #4 | $57,980 | 10,066 | $0 | 0 | +10,066 | New Buy |
| Arax Advisory Partners |
| <0.01% | <0.01% | #23 | $48,234 | 8,374 | $23 | 24 | +8,350+34,791.67% | Add |
| Vanguard Global Advisers, LLC |
| <0.01% | <0.01% | #51 | $33,944 | 5,893 | $22,217 | 5,893 | 00.00% | Unchanged |
| Steward Partners Investment Advisory, LLC |
| <0.01% | <0.01% | #31 | $23,904 | 4,150 | $15,646 | 4,150 | 00.00% | Unchanged |
| China Universal Asset Management Co., Ltd. |
| <0.01% | <0.01% | #15 | $19,999 | 3,472 | $14,567 | 3,864 | -392-10.14% | Reduce |
| Tower Research Capital LLC (TRC) |
| <0.01% | <0.01% | #22 | $14,406 | 2,501 | $20,611 | 5,467 | -2,966-54.25% | Reduce |
| BARCLAYS PLC |
| <0.01% | <0.01% | #66 | $13,012 | 2,259 | $13,651 | 3,621 | -1,362-37.61% | Reduce |
| Integrated Wealth Concepts LLC |
| <0.01% | — | #41 | $11,194 | 1,943 | $0 | 0 | +1,943 | New Buy |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #70 | $9,241 | 1,784 | $24,086 | 6,617 | -4,833-73.04% | Reduce |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #65 | $7,534 | 1,308 | $12,192 | 3,234 | -1,926-59.55% | Reduce |
| Russell Investments Group, Ltd. |
| <0.01% | <0.01% | #61 | $7,137 | 1,239 | $1,768 | 469 | +770+164.18% | Add |
| Stone House Investment Management, LLC |
| <0.01% | <0.01% | #19 | $5,760 | 1,000 | $3,770 | 1,000 | 00.00% | Unchanged |
