| Frazier Life Sciences Management, L.P. |
| 0.23% | 0.26% | #2 | $10.7M | 500,333 | $10.0M | 500,333 | 00.00% | Unchanged |
| RA CAPITAL MANAGEMENT, L.P. |
| 0.06% | 0.07% | #4 | $7.1M | 333,333 | $6.7M | 333,333 | 00.00% | Unchanged |
| Affinity Asset Advisors, LLC |
| 0.24% | 0.25% | #1 | $5.3M | 245,000 | $4.9M | 245,000 | 00.00% | Unchanged |
| Bain Capital Life Sciences Investors, LLC |
| 0.13% | 0.18% | #3 | $2.1M | 99,999 | $2.0M | 99,999 | 00.00% | Unchanged |
| DEERFIELD MANAGEMENT COMPANY, L.P. |
| 0.02% | 0.02% | #5 | $2.0M | 92,787 | $1.9M | 92,787 | 00.00% | Unchanged |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #9 | $1.6M | 75,000 | $1.5M | 75,000 | 00.00% | Unchanged |
| ARISTEIA CAPITAL, L.L.C. |
| <0.01% | 0.01% | #6 | $343,377 | 15,708 | $342,670 | 15,708 | 00.00% | Unchanged |
| WOLVERINE ASSET MANAGEMENT LLC |
| <0.01% | <0.01% | #8 | $318,947 | 14,925 | $42,625 | 2,127 | +12,798+601.69% | Add |
| Vestcor Inc |
| <0.01% | <0.01% | #7 | $142,452 | 6,666 | $131,000 | 6,666 | 00.00% | Unchanged |
| UBS Group AG |
| <0.01% | <0.01% | #10 | $8,523 | 443 | $7,936 | 396 | +47+11.87% | Add |
