| FEDERATED HERMES, INC. |
| 0.04% | 0.05% | #11 | $25.9M | 4.7M | $30.8M | 5.1M | -442,798-8.66% | Reduce |
| Jupiter Topco LLC |
| 0.01% | — | #14 | $24.3M | 4.4M | $0 | 0 | +4.4M | New Buy |
| Vivo Capital, LLC |
| 2.19% | 2.17% | #3 | $24.0M | 4.3M | $26.0M | 4.3M | 00.00% | Unchanged |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.03% | 0.03% | #12 | $23.6M | 4.3M | $25.7M | 4.3M | -1,600-0.04% | Reduce |
| Logos Global Management LP |
| 0.79% | 0.97% | #8 | $18.3M | 3.3M | $19.4M | 3.2M | +73,777+2.29% | Add |
| FARALLON CAPITAL MANAGEMENT, L.L.C. |
| 0.06% | 0.08% | #10 | $13.1M | 2.4M | $14.2M | 2.4M | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #28 | $12.4M | 2.2M | $3.8M | 624,857 | +1.6M+258.57% | Add |
| Ally Bridge Group (NY) LLC |
| 10.68% | 8.06% | #1 | $12.1M | 2.2M | $10.0M | 1.7M | +520,302+31.43% | Add |
| Foresite Capital Management VI LLC |
| 1.71% | 2.6% | #5 | $11.0M | 2.0M | $12.0M | 2.0M | -1,016-0.05% | Reduce |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #26 | $10.5M | 1.9M | $11.1M | 1.8M | +46,976+2.54% | Add |
| Spruce Street Capital LP |
| 1.8% | 2.4% | #4 | $9.2M | 1.7M | $10.0M | 1.7M | 00.00% | Unchanged |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.01% | 0.01% | #13 | $7.9M | 1.4M | $8.5M | 1.4M | 00.00% | Unchanged |
| Trails Edge Capital Partners, LP |
| 1.25% | 1.96% | #6 | $7.9M | 1.4M | $8.5M | 1.4M | 00.00% | Unchanged |
| Seven Fleet Capital Management LP |
| 0.92% | 0.48% | #7 | $5.6M | 1.0M | $1.5M | 248,476 | +752,897+303.01% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #25 | $5.4M | 974,236 | $2.0M | 338,735 | +635,501+187.61% | Add |
| DV EQUITIES, LLC |
| 0.6% | — | #9 | $4.2M | 754,397 | $0 | 0 | +754,397 | New Buy |
| ACUTA CAPITAL PARTNERS, LLC |
| 2.74% | 3.02% | #2 | $3.9M | 709,500 | $4.3M | 709,500 | 00.00% | Unchanged |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #18 | $3.0M | 533,602 | $4.3M | 708,291 | -174,689-24.66% | Reduce |
| STATE STREET CORP |
| <0.01% | <0.01% | #34 | $2.4M | 424,915 | $339,503 | 56,349 | +368,566+654.08% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #23 | $1.7M | 302,604 | $1.6M | 264,047 | +38,557+14.60% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #27 | $1.6M | 292,117 | $562,181 | 93,308 | +198,809+213.07% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #38 | $1.3M | 234,754 | $0 | 0 | +234,754 | New Buy |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #35 | $798,945 | 143,954 | $192,872 | 32,012 | +111,942+349.69% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #33 | $630,619 | 113,625 | $186,775 | 31,000 | +82,625+266.53% | Add |
| Bank of New York Mellon Corp |
| <0.01% | — | #36 | $419,468 | 75,580 | $0 | 0 | +75,580 | New Buy |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #19 | $406,815 | 73,300 | $540,444 | 89,700 | -16,400-18.28% | Reduce |
| Y-Intercept (Hong Kong) Ltd |
| 0.01% | — | #15 | $359,013 | 64,687 | $0 | 0 | +64,687 | New Buy |
| Walleye Capital LLC |
| <0.01% | — | #17 | $299,128 | 53,897 | $0 | 0 | +53,897 | New Buy |
| Nuveen, LLC |
| <0.01% | — | #37 | $252,403 | 45,478 | $0 | 0 | +45,478 | New Buy |
| UBS Group AG |
| <0.01% | <0.01% | #43 | $234,254 | 42,208 | $407,109 | 67,570 | -25,362-37.53% | Reduce |
| Invesco Ltd. |
| <0.01% | — | #48 | $220,274 | 39,689 | $0 | 0 | +39,689 | New Buy |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #50 | $209,413 | 37,732 | $240,819 | 39,970 | -2,238-5.60% | Reduce |
| Apella Capital, LLC |
| <0.01% | <0.01% | #16 | $201,533 | 42,250 | $284,343 | 42,250 | 00.00% | Unchanged |
| DEUTSCHE BANK AG\ |
| <0.01% | — | #40 | $184,687 | 33,277 | $0 | 0 | +33,277 | New Buy |
| WELLS FARGO & COMPANY/MN |
| <0.01% | — | #46 | $167,993 | 30,269 | $0 | 0 | +30,269 | New Buy |
| RHUMBLINE ADVISERS |
| <0.01% | — | #30 | $165,755 | 29,867 | $0 | 0 | +29,867 | New Buy |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | — | #49 | $154,962 | 27,921 | $0 | 0 | +27,921 | New Buy |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #32 | $142,496 | 25,675 | $128,899 | 21,394 | +4,281+20.01% | Add |
| NEW YORK STATE COMMON RETIREMENT FUND |
| <0.01% | — | #29 | $109,890 | 19,800 | $0 | 0 | +19,800 | New Buy |
| CITIGROUP INC |
| <0.01% | — | #44 | $88,650 | 15,973 | $0 | 0 | +15,973 | New Buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
| <0.01% | — | #31 | $87,013 | 15,678 | $0 | 0 | +15,678 | New Buy |
| Vanguard Global Advisers, LLC |
| <0.01% | <0.01% | #41 | $85,109 | 15,335 | $143,714 | 23,853 | -8,518-35.71% | Reduce |
| JPMORGAN CHASE & CO |
| <0.01% | — | #55 | $76,644 | 14,115 | $0 | 0 | +14,115 | New Buy |
| MORGAN STANLEY |
| <0.01% | <0.01% | #57 | $69,058 | 12,443 | $23,172 | 11,008 | +1,435+13.04% | Add |
| Police & Firemen's Retirement System of New Jersey |
| <0.01% | — | #22 | $57,420 | 10,346 | $0 | 0 | +10,346 | New Buy |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #47 | $43,806 | 7,893 | $374 | 62 | +7,831+12,630.65% | Add |
| BARCLAYS PLC |
| <0.01% | <0.01% | #52 | $37,884 | 6,826 | $880 | 146 | +6,680+4,575.34% | Add |
| Tower Research Capital LLC (TRC) |
| <0.01% | — | #20 | $20,407 | 3,677 | $0 | 0 | +3,677 | New Buy |
| Legal & General Group Plc |
| <0.01% | — | #56 | $18,426 | 3,320 | $0 | 0 | +3,320 | New Buy |
| Ameritas Investment Partners, Inc. |
| <0.01% | — | #21 | $17,150 | 3,090 | $0 | 0 | +3,090 | New Buy |
