| BROWN ADVISORY INC |
| 0.05% | 0.04% | #19 | $32.1M | 1.7M | $24.1M | 1.5M | +160,965+10.60% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #62 | $24.3M | 1.3M | $18.6M | 1.2M | +98,668+8.40% | Add |
| BRAIDWELL LP |
| 0.78% | 0.58% | #2 | $21.1M | 1.1M | $17.5M | 1.1M | 00.00% | Unchanged |
| Granahan Investment Management, LLC |
| 0.74% | 0.69% | #3 | $20.8M | 1.1M | $14.2M | 896,741 | +189,223+21.10% | Add |
| MILLENNIUM MANAGEMENT LLC |
| 0.01% | 0.01% | #30 | $15.6M | 816,830 | $19.6M | 1.2M | -420,069-33.96% | Reduce |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #34 | $15.2M | 794,309 | $14.1M | 887,444 | -93,135-10.49% | Reduce |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #65 | $14.5M | 755,624 | $11.4M | 718,176 | +37,448+5.21% | Add |
| Soleus Capital Management, L.P. |
| 0.48% | 0.4% | #7 | $14.0M | 732,144 | $9.8M | 615,447 | +116,697+18.96% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #51 | $13.3M | 693,387 | $20.6M | 1.1M | -418,061-37.61% | Reduce |
| WASATCH ADVISORS LP |
| 0.06% | 0.03% | #16 | $9.9M | 515,677 | $5.2M | 329,320 | +186,357+56.59% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #38 | $9.2M | 480,848 | $8.7M | 546,626 | -65,778-12.03% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #59 | $8.7M | 452,354 | $6.9M | 432,668 | +19,686+4.55% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #68 | $7.5M | 391,630 | $6.6M | 414,041 | -22,411-5.41% | Reduce |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #48 | $6.4M | 334,651 | $2.9M | 185,393 | +149,258+80.51% | Add |
| Roubaix Capital, LLC |
| 2.1% | 2.15% | #1 | $5.9M | 306,564 | $4.6M | 290,047 | +16,517+5.69% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #55 | $5.8M | 304,712 | $5.4M | 342,443 | -37,731-11.02% | Reduce |
| AIGH Capital Management LLC |
| 0.33% | — | #9 | $5.2M | 269,765 | $0 | 0 | +269,765 | New Buy |
| Nantahala Capital Management, LLC |
| 0.15% | 0.12% | #12 | $4.6M | 242,342 | $3.2M | 199,449 | +42,893+21.51% | Add |
| AWM Investment Company, Inc. |
| 0.39% | 0.42% | #8 | $4.5M | 237,169 | $3.8M | 237,169 | 00.00% | Unchanged |
| Nuveen, LLC |
| <0.01% | <0.01% | #41 | $4.3M | 222,869 | $2.6M | 163,987 | +58,882+35.91% | Add |
| HARBOR CAPITAL ADVISORS, INC. |
| 0.26% | 0.17% | #10 | $3.8M | 199,682 | $2.2M | 135,985 | +63,697+46.84% | Add |
| Squarepoint Ops LLC |
| <0.01% | <0.01% | #33 | $3.7M | 195,468 | $1.6M | 100,238 | +95,230+95.00% | Add |
| DAFNA Capital Management LLC |
| 0.69% | 0.35% | #4 | $3.6M | 189,130 | $1.5M | 95,659 | +93,471+97.71% | Add |
| KENNEDY CAPITAL MANAGEMENT LLC |
| 0.06% | 0.06% | #17 | $3.5M | 182,871 | $3.0M | 186,321 | -3,450-1.85% | Reduce |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #74 | $3.3M | 171,268 | $2.4M | 150,298 | +20,970+13.95% | Add |
| TUDOR INVESTMENT CORP ET AL |
| <0.01% | <0.01% | #32 | $3.3M | 170,022 | $2.7M | 168,983 | +1,039+0.61% | Add |
| Triodos Investment Management BV |
| 0.19% | 0.18% | #11 | $3.2M | 165,000 | $2.3M | 147,000 | +18,000+12.24% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #63 | $3.0M | 157,789 | $2.4M | 150,431 | +7,358+4.89% | Add |
| Prosight Management, LP |
| 0.52% | 0.79% | #6 | $3.0M | 157,500 | $4.8M | 302,399 | -144,899-47.92% | Reduce |
| RIVERBRIDGE PARTNERS LLC |
| 0.08% | — | #15 | $3.0M | 155,315 | $0 | 0 | +155,315 | New Buy |
| BROWN CAPITAL MANAGEMENT LLC |
| 0.59% | 0.7% | #5 | $2.9M | 153,314 | $4.9M | 310,548 | -157,234-50.63% | Reduce |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC |
| 0.03% | 0.03% | #20 | $2.8M | 145,578 | $2.4M | 153,123 | -7,545-4.93% | Reduce |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #60 | $2.7M | 143,127 | $2.2M | 139,097 | +4,030+2.90% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #56 | $2.2M | 117,274 | $1.9M | 120,254 | -2,980-2.48% | Reduce |
| LAZARD ASSET MANAGEMENT LLC |
| <0.01% | — | #35 | $1.8M | 92,249 | $0 | 0 | +92,249 | New Buy |
| D. E. Shaw & Co., Inc. |
| <0.01% | <0.01% | #46 | $1.7M | 91,415 | $1.2M | 73,071 | +18,344+25.10% | Add |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #77 | $1.6M | 81,403 | $1.4M | 91,224 | -9,821-10.77% | Reduce |
| AQR CAPITAL MANAGEMENT LLC |
| <0.01% | — | #54 | $1.5M | 78,291 | $0 | 0 | +78,291 | New Buy |
| COMMONWEALTH EQUITY SERVICES, LLC |
| <0.01% | <0.01% | #37 | $1.4M | 72,123 | $1.1M | 72,123 | 00.00% | Unchanged |
| Conestoga Capital Advisors, LLC |
| 0.03% | 0.02% | #21 | $1.2M | 64,535 | $1.0M | 64,535 | 00.00% | Unchanged |
| SEI INVESTMENTS CO |
| <0.01% | <0.01% | #40 | $1.2M | 64,245 | $1.3M | 82,081 | -17,836-21.73% | Reduce |
| NORGES BANK |
| <0.01% | — | #80 | $1.2M | 63,500 | $0 | 0 | +63,500 | New Buy |
| Prime Capital Investment Advisors, LLC |
| 0.01% | 0.01% | #24 | $1.2M | 62,451 | $990,415 | 62,408 | +43+0.07% | Add |
| CenterBook Partners LP |
| 0.05% | 0.07% | #18 | $1.1M | 56,895 | $1.3M | 79,396 | -22,501-28.34% | Reduce |
| HRT FINANCIAL LP |
| <0.01% | <0.01% | #36 | $1.1M | 55,483 | $769,000 | 48,489 | +6,994+14.42% | Add |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #73 | $991,852 | 51,848 | $787,723 | 49,636 | +2,212+4.46% | Add |
| Grandeur Peak Global Advisors, LLC |
| 0.1% | 0.35% | #14 | $953,707 | 49,854 | $1.5M | 94,090 | -44,236-47.01% | Reduce |
| PARADIGM CAPITAL MANAGEMENT INC/NY |
| 0.02% | 0.03% | #22 | $899,110 | 47,000 | $745,890 | 47,000 | 00.00% | Unchanged |
| Trexquant Investment LP |
| 0.01% | <0.01% | #31 | $876,690 | 45,828 | $250,191 | 15,765 | +30,063+190.69% | Add |
| AMERICAN CENTURY COMPANIES INC |
| <0.01% | <0.01% | #64 | $774,822 | 40,503 | $644,830 | 40,632 | -129-0.32% | Reduce |
