| FMR LLC |
| <0.01% | <0.01% | #29 | $9.3M | 8.5M | $16.3M | 9.3M | -884,817-9.47% | Reduce |
| Jupiter Topco LLC |
| <0.01% | — | #14 | $5.7M | 5.2M | $0 | 0 | +5.2M | New Buy |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #48 | $4.0M | 3.7M | $5.0M | 2.9M | +749,354+25.83% | Add |
| Boxer Capital Management, LLC |
| 0.24% | 0.54% | #1 | $3.1M | 2.8M | $4.1M | 2.4M | +474,872+20.04% | Add |
| ADAR1 Capital Management, LLC |
| 0.11% | 0.15% | #3 | $2.4M | 2.1M | $2.6M | 1.5M | +673,802+45.83% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #44 | $1.7M | 1.6M | $801,552 | 460,662 | +1.1M+242.62% | Add |
| D. E. Shaw & Co., Inc. |
| <0.01% | <0.01% | #23 | $1.5M | 1.4M | $3.9M | 2.2M | -861,163-38.92% | Reduce |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #21 | $1.4M | 1.2M | $679,268 | 390,384 | +849,394+217.58% | Add |
| Stonepine Capital Management, LLC |
| 0.21% | — | #2 | $1.3M | 1.3M | $0 | 0 | +1.3M | New Buy |
| Eversept Partners, LP |
| 0.06% | 0.09% | #4 | $1.1M | 1.0M | $1.8M | 1.0M | 00.00% | Unchanged |
| Caption Management, LLC |
| <0.01% | — | #9 | $966,845 | 878,950 | $0 | 0 | +878,950 | New Buy |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #54 | $883,749 | 802,751 | $1.4M | 801,504 | +1,247+0.16% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #33 | $875,718 | 796,107 | $2.5M | 1.4M | -614,738-43.57% | Reduce |
| BlackRock, Inc. |
| <0.01% | <0.01% | #65 | $856,963 | 779,057 | $1.2M | 662,181 | +116,876+17.65% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #49 | $710,022 | 645,475 | $734,022 | 421,852 | +223,623+53.01% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #45 | $528,846 | 480,769 | $682,195 | 392,066 | +88,703+22.62% | Add |
| SIMPLEX TRADING, LLC |
| <0.01% | <0.01% | #32 | $518,540 | 471,400 | $198,882 | 114,300 | +357,100+312.42% | Add |
| GROUP ONE TRADING LLC |
| <0.01% | <0.01% | #24 | $509,520 | 463,200 | $164,778 | 94,700 | +368,500+389.12% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #25 | $397,473 | 361,339 | $1.1M | 643,777 | -282,438-43.87% | Reduce |
| STATE STREET CORP |
| <0.01% | <0.01% | #67 | $370,271 | 336,610 | $515,579 | 296,310 | +40,300+13.60% | Add |
| TUDOR INVESTMENT CORP ET AL |
| <0.01% | — | #27 | $330,000 | 300,000 | $0 | 0 | +300,000 | New Buy |
| DIADEMA PARTNERS LP |
| 0.04% | 0.19% | #6 | $302,720 | 275,200 | $1.1M | 637,865 | -362,665-56.86% | Reduce |
| GSA CAPITAL PARTNERS LLP |
| 0.02% | 0.03% | #7 | $291,512 | 265,011 | $461,000 | 265,075 | -64-0.02% | Reduce |
| UBS Group AG |
| <0.01% | <0.01% | #56 | $288,552 | 262,320 | $434,392 | 249,650 | +12,670+5.08% | Add |
| Quadrature Capital Ltd |
| <0.01% | — | #13 | $284,821 | 258,928 | $0 | 0 | +258,928 | New Buy |
| IMC-Chicago, LLC |
| <0.01% | <0.01% | #52 | $234,190 | 212,900 | $65,927 | 37,889 | +175,011+461.90% | Add |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #59 | $208,917 | 189,925 | $144,230 | 82,891 | +107,034+129.13% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #58 | $191,833 | 174,394 | $520,034 | 298,870 | -124,476-41.65% | Reduce |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| <0.01% | 0.01% | #11 | $190,300 | 173,000 | $301,020 | 173,000 | 00.00% | Unchanged |
| NOMURA HOLDINGS INC |
| <0.01% | — | #39 | $165,000 | 150,000 | $0 | 0 | +150,000 | New Buy |
| HRT FINANCIAL LP |
| <0.01% | <0.01% | #34 | $154,475 | 140,432 | $22,000 | 12,917 | +127,515+987.19% | Add |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main |
| <0.01% | — | #46 | $147,012 | 133,648 | $0 | 0 | +133,648 | New Buy |
| GMT CAPITAL CORP |
| 0.01% | 0.01% | #8 | $138,731 | 126,119 | $219,447 | 126,119 | 00.00% | Unchanged |
| XTX Topco Ltd |
| <0.01% | 0.01% | #18 | $116,416 | 105,833 | $370,058 | 212,677 | -106,844-50.24% | Reduce |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #68 | $103,092 | 93,720 | $77,820 | 44,724 | +48,996+109.55% | Add |
| Invesco Ltd. |
| <0.01% | — | #71 | $88,372 | 80,338 | $0 | 0 | +80,338 | New Buy |
| Green Alpha Advisors, LLC |
| 0.05% | 0.11% | #5 | $74,861 | 68,055 | $114,109 | 65,580 | +2,475+3.77% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #80 | $55,283 | 50,256 | $1.8M | 786,774 | -736,518-93.61% | Reduce |
| RAYMOND JAMES FINANCIAL INC |
| <0.01% | <0.01% | #66 | $46,515 | 42,286 | $28,785 | 16,543 | +25,743+155.61% | Add |
| Squarepoint Ops LLC |
| <0.01% | <0.01% | #55 | $40,030 | 36,391 | $43,216 | 24,837 | +11,554+46.52% | Add |
| Engineers Gate Manager LP |
| <0.01% | — | #26 | $37,060 | 33,691 | $0 | 0 | +33,691 | New Buy |
| Greenwich Wealth Management LLC |
| <0.01% | <0.01% | #19 | $35,199 | 31,999 | $43,000 | 24,899 | +7,100+28.52% | Add |
| Vanguard Global Advisers, LLC |
| <0.01% | <0.01% | #61 | $33,259 | 30,235 | $52,609 | 30,235 | 00.00% | Unchanged |
| Headlands Technologies LLC |
| <0.01% | — | #10 | $32,878 | 29,889 | $0 | 0 | +29,889 | New Buy |
| ZACKS INVESTMENT MANAGEMENT |
| <0.01% | — | #38 | $29,079 | 26,435 | $0 | 0 | +26,435 | New Buy |
| Prime Capital Investment Advisors, LLC |
| <0.01% | <0.01% | #41 | $18,839 | 17,126 | $29,799 | 17,126 | 00.00% | Unchanged |
| LPL Financial LLC |
| <0.01% | <0.01% | #73 | $18,826 | 17,114 | $32,323 | 18,576 | -1,462-7.87% | Reduce |
| StoneX Group Inc. |
| <0.01% | — | #22 | $18,077 | 14,252 | $0 | 0 | +14,252 | New Buy |
| TWO SIGMA SECURITIES, LLC |
| <0.01% | — | #16 | $17,554 | 15,958 | $0 | 0 | +15,958 | New Buy |
| STEPHENS INC /AR/ |
| <0.01% | <0.01% | #40 | $17,050 | 15,500 | $26,970 | 15,500 | 00.00% | Unchanged |
