| Jupiter Topco LLC |
| 0.01% | — | #18 | $17.9M | 4.7M | $0 | 0 | +4.7M | New Buy |
| BlackRock, Inc. |
| <0.01% | <0.01% | #59 | $14.0M | 3.7M | $17.7M | 3.4M | +268,531+7.91% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | 0.01% | #26 | $11.8M | 3.1M | $14.8M | 2.8M | +269,958+9.54% | Add |
| Velan Capital Investment Management LP |
| 6.62% | 9.25% | #1 | $10.9M | 2.8M | $14.8M | 2.8M | +10,000+0.35% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #61 | $8.8M | 2.3M | $11.0M | 2.1M | +181,115+8.55% | Add |
| Blackstone Inc. |
| 0.03% | 0.05% | #12 | $8.7M | 2.3M | $11.8M | 2.3M | 00.00% | Unchanged |
| ORBIMED ADVISORS LLC |
| 0.16% | — | #10 | $8.5M | 2.2M | $0 | 0 | +2.2M | New Buy |
| Sio Capital Management, LLC |
| 1.21% | 1.47% | #4 | $7.3M | 1.9M | $10.3M | 2.0M | -47,967-2.44% | Reduce |
| ACORN CAPITAL ADVISORS, LLC |
| 1.83% | 2.59% | #2 | $6.7M | 1.8M | $9.1M | 1.8M | 00.00% | Unchanged |
| Integral Health Asset Management, LLC |
| 0.23% | 0.44% | #8 | $5.7M | 1.5M | $9.1M | 1.8M | -250,000-14.29% | Reduce |
| 5AM Venture Management, LLC |
| 1.82% | 1.98% | #3 | $5.2M | 1.4M | $7.1M | 1.4M | 00.00% | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #54 | $5.1M | 1.3M | $6.1M | 1.2M | +149,046+12.66% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #37 | $4.7M | 1.2M | $6.4M | 1.2M | -93-0.01% | Reduce |
| STATE STREET CORP |
| <0.01% | <0.01% | #65 | $4.1M | 1.1M | $5.2M | 1.0M | +63,153+6.28% | Add |
| Qube Research & Technologies Ltd |
| <0.01% | <0.01% | #27 | $4.0M | 1.0M | $922,191 | 177,004 | +868,512+490.67% | Add |
| BALYASNY ASSET MANAGEMENT L.P. |
| <0.01% | — | #23 | $3.9M | 1.0M | $0 | 0 | +1.0M | New Buy |
| BAKER BROS. ADVISORS LP |
| 0.02% | 0.03% | #13 | $3.7M | 971,614 | $5.1M | 971,614 | 00.00% | Unchanged |
| ADAR1 Capital Management, LLC |
| 0.17% | 0.29% | #9 | $3.6M | 940,512 | $4.9M | 940,512 | 00.00% | Unchanged |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #57 | $3.4M | 882,179 | $4.8M | 925,918 | -43,739-4.72% | Reduce |
| MARSHALL WACE, LLP |
| <0.01% | <0.01% | #30 | $2.7M | 701,021 | $264,308 | 50,731 | +650,290+1,281.84% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #41 | $2.6M | 683,230 | $2.8M | 531,267 | +151,963+28.60% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #55 | $2.1M | 552,306 | $2.0M | 374,852 | +177,454+47.34% | Add |
| Point72 Asset Management, L.P. |
| <0.01% | 0.01% | #29 | $2.1M | 548,932 | $6.0M | 1.2M | -603,782-52.38% | Reduce |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #63 | $2.1M | 546,227 | $2.1M | 397,981 | +148,246+37.25% | Add |
| Catalio Capital Management, LP |
| 0.37% | 0.63% | #6 | $2.0M | 520,148 | $3.0M | 580,024 | -59,876-10.32% | Reduce |
| MORGAN STANLEY |
| <0.01% | <0.01% | #69 | $1.9M | 508,434 | $472,166 | 108,544 | +399,890+368.41% | Add |
| Walleye Capital LLC |
| 0.01% | 0.01% | #19 | $1.9M | 505,432 | $2.3M | 443,401 | +62,031+13.99% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #71 | $1.9M | 491,657 | $2.1M | 412,604 | +79,053+19.16% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #56 | $1.7M | 456,773 | $7.3M | 1.4M | -945,640-67.43% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #51 | $1.3M | 334,683 | $1.6M | 308,842 | +25,841+8.37% | Add |
| Verdad Advisers, LP |
| 1.14% | — | #5 | $1.2M | 312,249 | $0 | 0 | +312,249 | New Buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC |
| <0.01% | <0.01% | #24 | $1.1M | 295,565 | $261,829 | 50,255 | +245,310+488.13% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #32 | $960,730 | 251,500 | $654,897 | 125,700 | +125,800+100.08% | Add |
| OPPENHEIMER & CO INC |
| 0.01% | 0.01% | #17 | $910,543 | 238,362 | $945,954 | 181,565 | +56,797+31.28% | Add |
| AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #52 | $798,262 | 208,969 | $348,053 | 66,805 | +142,164+212.80% | Add |
| Jump Financial, LLC |
| 0.01% | <0.01% | #20 | $775,842 | 203,100 | $347,919 | 66,779 | +136,321+204.14% | Add |
| CIBC WORLD MARKET INC. |
| <0.01% | <0.01% | #35 | $636,011 | 166,495 | $914,329 | 175,495 | -9,000-5.13% | Reduce |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #73 | $603,449 | 157,971 | $770,496 | 147,888 | +10,083+6.82% | Add |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #70 | $525,971 | 137,689 | $675,583 | 129,671 | +8,018+6.18% | Add |
| J. Goldman & Co LP |
| 0.01% | 0.13% | #16 | $515,700 | 135,000 | $4.5M | 856,247 | -721,247-84.23% | Reduce |
| SUPERSTRING CAPITAL MANAGEMENT LP |
| 0.29% | 0.45% | #7 | $463,966 | 121,457 | $632,791 | 121,457 | 00.00% | Unchanged |
| Fisher Asset Management, LLC |
| <0.01% | — | #66 | $380,342 | 99,566 | $0 | 0 | +99,566 | New Buy |
| AMERICAN CENTURY COMPANIES INC |
| <0.01% | <0.01% | #64 | $376,220 | 98,487 | $484,368 | 92,969 | +5,518+5.94% | Add |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| 0.01% | 0.01% | #21 | $325,961 | 85,330 | $366,419 | 70,330 | +15,000+21.33% | Add |
| Nuveen, LLC |
| <0.01% | <0.01% | #76 | $277,371 | 72,610 | $332,711 | 63,860 | +8,750+13.70% | Add |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #60 | $266,071 | 69,652 | $197,136 | 37,838 | +31,814+84.08% | Add |
| FMR LLC |
| <0.01% | <0.01% | #100 | $260,524 | 68,200 | $297,465 | 57,095 | +11,105+19.45% | Add |
| XTX Topco Ltd |
| <0.01% | 0.01% | #28 | $244,281 | 63,948 | $306,353 | 58,801 | +5,147+8.75% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #95 | $241,730 | 63,280 | $899,902 | 172,726 | -109,446-63.36% | Reduce |
| RHUMBLINE ADVISERS |
| <0.01% | <0.01% | #62 | $241,589 | 63,245 | $167,103 | 32,075 | +31,170+97.18% | Add |
