| Alphabet Inc. |
| 1.34% | 1.44% | #2 | $57.6M | 16.6M | $57.6M | 16.6M | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #83 | $35.4M | 9.6M | $29.6M | 8.5M | +1.1M+12.94% | Add |
| ARK Investment Management LLC |
| 0.2% | 0.17% | #8 | $30.8M | 8.3M | $21.7M | 6.2M | +2.1M+33.65% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #69 | $28.0M | 7.6M | $22.1M | 6.3M | +1.2M+19.41% | Add |
| T. Rowe Price Investment Management, Inc. |
| 0.01% | 0.01% | #25 | $19.3M | 5.2M | $19.1M | 5.5M | -244,561-4.46% | Reduce |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #93 | $16.7M | 4.5M | $15.6M | 4.5M | +48,478+1.08% | Add |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.02% | 0.02% | #23 | $14.6M | 4.0M | $14.3M | 4.1M | -154,283-3.74% | Reduce |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #62 | $12.7M | 3.4M | $3.4M | 970,425 | +2.5M+253.51% | Add |
| Casdin Capital, LLC |
| 0.58% | 0.83% | #4 | $11.7M | 3.2M | $11.0M | 3.2M | 00.00% | Unchanged |
| Woodline Partners LP |
| 0.03% | 0.04% | #18 | $11.1M | 3.0M | $10.5M | 3.0M | +591+0.02% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #54 | $10.3M | 2.8M | $10.1M | 2.9M | -93,729-3.24% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #79 | $10.0M | 2.7M | $9.6M | 2.7M | -31,254-1.14% | Reduce |
| Sumitomo Mitsui Trust Group, Inc. |
| 0.01% | 0.01% | #31 | $8.9M | 2.4M | $10.2M | 2.9M | -527,809-17.95% | Reduce |
| Amova Asset Management Americas, Inc. |
| 0.11% | 0.14% | #9 | $8.9M | 2.4M | $10.2M | 2.9M | -533,775-18.15% | Reduce |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #64 | $8.7M | 2.4M | $2.1M | 598,058 | +1.8M+293.51% | Add |
| ADAR1 Capital Management, LLC |
| 0.34% | 0.4% | #7 | $7.4M | 2.0M | $6.9M | 2.0M | +24,270+1.23% | Add |
| FMR LLC |
| <0.01% | <0.01% | #101 | $6.5M | 1.8M | $6.2M | 1.8M | -7,592-0.43% | Reduce |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #34 | $5.6M | 1.5M | $5.5M | 1.6M | -48,300-3.07% | Reduce |
| Redmile Group, LLC |
| 0.34% | 0.37% | #6 | $5.1M | 1.4M | $5.5M | 1.6M | -201,200-12.65% | Reduce |
| FARALLON CAPITAL MANAGEMENT, L.L.C. |
| 0.02% | 0.02% | #22 | $4.6M | 1.2M | $4.3M | 1.2M | 00.00% | Unchanged |
| Jump Financial, LLC |
| 0.04% | — | #16 | $4.6M | 1.2M | $0 | 0 | +1.2M | New Buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #94 | $4.5M | 1.2M | $4.7M | 1.3M | -124,050-9.19% | Reduce |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #108 | $3.6M | 981,335 | $2.0M | 577,004 | +404,331+70.07% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #122 | $3.5M | 961,826 | $3.0M | 862,204 | +99,622+11.55% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #87 | $3.4M | 927,538 | $3.2M | 917,212 | +10,326+1.13% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #91 | $3.4M | 912,597 | $3.1M | 886,716 | +25,881+2.92% | Add |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #121 | $3.0M | 810,095 | $2.7M | 844,154 | -34,059-4.03% | Reduce |
| Greenwich Wealth Management LLC |
| 0.1% | 0.11% | #10 | $2.8M | 768,001 | $2.6M | 750,001 | +18,000+2.40% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #75 | $2.8M | 764,633 | $2.5M | 717,002 | +47,631+6.64% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #129 | $2.6M | 708,963 | $4.0M | 731,004 | -22,041-3.02% | Reduce |
| Alessandra Capital Management, LLC |
| 1.74% | 1.26% | #1 | $2.5M | 666,603 | $1.5M | 425,510 | +241,093+56.66% | Add |
| D. E. Shaw & Co., Inc. |
| <0.01% | <0.01% | #60 | $2.4M | 648,940 | $4.8M | 1.4M | -744,681-53.43% | Reduce |
| Point72 Asset Management, L.P. |
| <0.01% | — | #45 | $2.0M | 533,553 | $0 | 0 | +533,553 | New Buy |
| MOORE CAPITAL MANAGEMENT, LP |
| 0.03% | 0.04% | #21 | $1.8M | 500,000 | $1.7M | 500,000 | 00.00% | Unchanged |
| CHELSEA COUNSEL CO |
| 0.7% | 0.72% | #3 | $1.7M | 449,060 | $1.6M | 462,340 | -13,280-2.87% | Reduce |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | — | #81 | $1.6M | 427,097 | $0 | 0 | +427,097 | New Buy |
| HighTower Advisors, LLC |
| <0.01% | <0.01% | #57 | $1.3M | 340,365 | $1.2M | 340,255 | +110+0.03% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #113 | $1.1M | 304,678 | $1.1M | 304,522 | +156+0.05% | Add |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #115 | $1.1M | 304,444 | $967,857 | 278,120 | +26,324+9.46% | Add |
| Nuveen, LLC |
| <0.01% | <0.01% | #105 | $1.0M | 275,931 | $960,240 | 275,931 | 00.00% | Unchanged |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #146 | $1.0M | 272,000 | $1.3M | 369,500 | -97,500-26.39% | Reduce |
| WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #124 | $928,947 | 251,747 | $1.1M | 319,550 | -67,803-21.22% | Reduce |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #125 | $909,010 | 246,344 | $929,922 | 267,219 | -20,875-7.81% | Reduce |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd |
| 0.05% | 0.05% | #15 | $833,198 | 225,799 | $714,754 | 205,389 | +20,410+9.94% | Add |
| MARSHALL WACE, LLP |
| <0.01% | <0.01% | #74 | $800,143 | 216,841 | $494,010 | 141,957 | +74,884+52.75% | Add |
| XTX Topco Ltd |
| 0.01% | 0.01% | #28 | $795,963 | 215,708 | $547,341 | 157,282 | +58,426+37.15% | Add |
| Jain Global LLC |
| <0.01% | — | #39 | $794,154 | 215,218 | $0 | 0 | +215,218 | New Buy |
| JUPITER ASSET MANAGEMENT LTD |
| <0.01% | — | #36 | $773,018 | 209,490 | $0 | 0 | +209,490 | New Buy |
| Swiss National Bank |
| <0.01% | <0.01% | #90 | $768,627 | 208,300 | $621,528 | 178,600 | +29,700+16.63% | Add |
| PEAK6 LLC |
| <0.01% | — | #51 | $767,730 | 208,057 | $0 | 0 | +208,057 | New Buy |
