| DEERFIELD MANAGEMENT COMPANY, L.P. |
| 1.13% | 1.89% | #4 | $108.6M | 35.6M | $160.2M | 35.6M | 00.00% | Unchanged |
| Blue Owl Capital Holdings LP |
| 4.39% | 9.12% | #1 | $30.1M | 9.9M | $34.0M | 8.1M | +1.8M+22.19% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #86 | $17.3M | 5.7M | $16.9M | 3.8M | +1.9M+51.33% | Add |
| Defilade Capital Management, L.P. |
| 1.5% | — | #2 | $11.2M | 3.7M | $0 | 0 | +3.7M | New Buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.06% | 0.1% | #11 | $9.6M | 3.2M | $13.2M | 2.9M | +229,024+7.80% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #95 | $9.1M | 3.0M | $12.9M | 2.9M | +108,552+3.79% | Add |
| RTW INVESTMENTS, LP |
| 0.07% | 0.07% | #9 | $7.8M | 2.6M | $6.8M | 1.5M | +1.1M+71.07% | Add |
| AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #37 | $7.2M | 2.4M | $3.7M | 817,517 | +1.6M+190.08% | Add |
| MARSHALL WACE, LLP |
| <0.01% | <0.01% | #27 | $6.1M | 2.0M | $4.2M | 933,464 | +1.1M+115.59% | Add |
| DAFNA Capital Management LLC |
| 1.17% | 2.08% | #3 | $6.1M | 2.0M | $9.1M | 2.0M | -21,000-1.03% | Reduce |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #63 | $5.6M | 1.8M | $7.4M | 1.7M | +191,325+11.58% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #57 | $5.2M | 1.7M | $2.7M | 600,132 | +1.1M+186.09% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #84 | $5.1M | 1.7M | $5.0M | 1.1M | +570,242+51.43% | Add |
| Qube Research & Technologies Ltd |
| <0.01% | <0.01% | #29 | $5.0M | 1.6M | $3.8M | 847,644 | +793,398+93.60% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #105 | $4.3M | 1.4M | $4.1M | 911,326 | +500,478+54.92% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #96 | $4.3M | 1.4M | $1.8M | 406,558 | +996,614+245.13% | Add |
| Woodline Partners LP |
| 0.01% | 0.02% | #20 | $4.3M | 1.4M | $6.3M | 1.4M | 00.00% | Unchanged |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | 0.01% | #46 | $4.1M | 1.3M | $16.3M | 3.6M | -2.3M-63.23% | Reduce |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #61 | $2.9M | 961,083 | $3.6M | 798,462 | +162,621+20.37% | Add |
| FMR LLC |
| <0.01% | <0.01% | #106 | $2.9M | 937,368 | $286,065 | 63,570 | +873,798+1,374.54% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #90 | $2.8M | 932,228 | $2.2M | 487,660 | +444,568+91.16% | Add |
| SPHERA FUNDS MANAGEMENT LTD. |
| 0.37% | — | #6 | $2.8M | 926,004 | $0 | 0 | +926,004 | New Buy |
| Nuveen, LLC |
| <0.01% | <0.01% | #56 | $2.7M | 895,304 | $3.0M | 674,915 | +220,389+32.65% | Add |
| Alyeska Investment Group, L.P. |
| <0.01% | 0.01% | #28 | $1.9M | 617,211 | $2.8M | 617,211 | 00.00% | Unchanged |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #94 | $1.7M | 550,266 | $1.7M | 376,503 | +173,763+46.15% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #82 | $1.4M | 448,168 | $1.3M | 289,632 | +158,536+54.74% | Add |
| Fi3 FINANCIAL ADVISORS, LLC |
| 0.3% | 0.04% | #7 | $1.3M | 2,915 | $132,719 | 29,493 | -26,578-90.12% | Reduce |
| LOS ANGELES CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #31 | $1.2M | 399,542 | $81,099 | 18,022 | +381,520+2,116.97% | Add |
| Hennion & Walsh Asset Management, Inc. |
| 0.03% | — | #15 | $1.2M | 396,726 | $0 | 0 | +396,726 | New Buy |
| SummitTX Capital, L.P. |
| 0.03% | 0.05% | #17 | $1.1M | 352,284 | $1.7M | 379,765 | -27,481-7.24% | Reduce |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #126 | $1.0M | 328,015 | $1.4M | 331,818 | -3,803-1.15% | Reduce |
| Gem Investment Advisors, LLC |
| 0.6% | 1.01% | #5 | $974,533 | 319,519 | $1.1M | 280,860 | +38,659+13.76% | Add |
| SIMPLEX TRADING, LLC |
| <0.01% | <0.01% | #58 | $939,119 | 307,908 | $1.0M | 233,100 | +74,808+32.09% | Add |
| Burkehill Global Management, LP |
| 0.03% | 0.07% | #16 | $915,000 | 300,000 | $1.4M | 300,000 | 00.00% | Unchanged |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | 0.01% | #47 | $907,201 | 297,443 | $3.3M | 739,942 | -442,499-59.80% | Reduce |
| ADAR1 Capital Management, LLC |
| 0.04% | 0.01% | #13 | $831,872 | 272,745 | $237,353 | 52,745 | +220,000+417.10% | Add |
| Cerity Partners LLC |
| <0.01% | <0.01% | #50 | $828,326 | 271,582 | $1.1M | 247,912 | +23,670+9.55% | Add |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #62 | $720,206 | 236,133 | $2.1M | 475,612 | -239,479-50.35% | Reduce |
| Seven Fleet Capital Management LP |
| 0.12% | 0.37% | #8 | $704,309 | 230,921 | $1.2M | 256,585 | -25,664-10.00% | Reduce |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #118 | $631,255 | 206,969 | $654,039 | 145,342 | +61,627+42.40% | Add |
| IEQ CAPITAL, LLC |
| <0.01% | <0.01% | #35 | $620,258 | 203,363 | $513,172 | 114,038 | +89,325+78.33% | Add |
| Caption Management, LLC |
| <0.01% | 0.02% | #36 | $588,705 | 193,018 | $3.6M | 799,224 | -606,206-75.85% | Reduce |
| Soleus Capital Management, L.P. |
| 0.02% | 0.19% | #19 | $573,711 | 188,102 | $4.8M | 1.1M | -878,858-82.37% | Reduce |
| JACOBS LEVY EQUITY MANAGEMENT, INC |
| <0.01% | <0.01% | #43 | $520,254 | 170,575 | $761,148 | 169,144 | +1,431+0.85% | Add |
| Susquehanna Portfolio Strategies, LLC |
| 0.01% | — | #24 | $503,726 | 165,156 | $0 | 0 | +165,156 | New Buy |
| ALLIANCEBERNSTEIN L.P. |
| <0.01% | <0.01% | #100 | $486,990 | 108,220 | $283,959 | 74,530 | +33,690+45.20% | Add |
| DIADEMA PARTNERS LP |
| 0.06% | 0.13% | #12 | $447,243 | 146,637 | $749,867 | 166,637 | -20,000-12.00% | Reduce |
| UBS Group AG |
| <0.01% | <0.01% | #128 | $440,194 | 144,326 | $133,646 | 29,699 | +114,627+385.96% | Add |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #121 | $423,435 | 138,831 | $482,989 | 107,331 | +31,500+29.35% | Add |
| STATE OF WISCONSIN INVESTMENT BOARD |
| <0.01% | <0.01% | #53 | $421,498 | 138,196 | $129,582 | 28,796 | +109,400+379.91% | Add |
