| RA CAPITAL MANAGEMENT, L.P. |
| 0.21% | 0.41% | #5 | $23.7M | 4.2M | $38.2M | 4.2M | 00.00% | Unchanged |
| Alpha Wave Global, LP |
| 0.33% | 4.18% | #4 | $20.5M | 3.6M | $33.1M | 3.6M | 00.00% | Unchanged |
| FMR LLC |
| <0.01% | <0.01% | #52 | $20.2M | 3.6M | $32.9M | 3.6M | -38,879-1.08% | Reduce |
| Versant Venture Management, LLC |
| 9.28% | 17.19% | #2 | $15.1M | 2.7M | $24.3M | 2.7M | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #70 | $13.0M | 2.3M | $18.1M | 2.0M | +315,298+15.95% | Add |
| Squarepoint Ops LLC |
| 0.01% | 0.02% | #23 | $9.9M | 1.7M | $13.8M | 1.5M | +240,597+15.97% | Add |
| Aberdeen Group plc |
| 0.01% | 0.02% | #22 | $8.8M | 1.5M | $10.6M | 1.2M | +391,722+33.88% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #34 | $8.6M | 1.5M | $8.0M | 869,257 | +639,221+73.54% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #79 | $6.2M | 1.1M | $9.5M | 1.0M | +56,567+5.43% | Add |
| 72 Investment Holdings, LLC |
| 11.57% | 18.77% | #1 | $5.8M | 1.0M | $9.3M | 1.0M | 00.00% | Unchanged |
| Blue Owl Capital Holdings LP |
| 0.63% | 1.25% | #3 | $4.3M | 756,722 | $4.6M | 506,722 | +250,000+49.34% | Add |
| C WorldWide Group Holding A/S |
| 0.1% | 0.14% | #8 | $4.0M | 700,000 | $6.4M | 700,000 | 00.00% | Unchanged |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #61 | $3.3M | 580,629 | $1.4M | 153,700 | +426,929+277.77% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #74 | $3.2M | 564,662 | $4.8M | 524,574 | +40,088+7.64% | Add |
| Trexquant Investment LP |
| 0.02% | 0.01% | #18 | $2.8M | 497,526 | $2.0M | 214,408 | +283,118+132.05% | Add |
| MARSHALL WACE, LLP |
| <0.01% | <0.01% | #39 | $2.8M | 493,099 | $1.5M | 160,264 | +332,835+207.68% | Add |
| Qube Research & Technologies Ltd |
| <0.01% | — | #37 | $2.7M | 482,195 | $0 | 0 | +482,195 | New Buy |
| MORGAN STANLEY |
| <0.01% | <0.01% | #77 | $2.7M | 472,995 | $13.8M | 296,219 | +176,776+59.68% | Add |
| PRIMECAP MANAGEMENT CO/CA/ |
| <0.01% | <0.01% | #45 | $2.7M | 472,200 | $4.3M | 472,200 | 00.00% | Unchanged |
| TANG CAPITAL MANAGEMENT LLC |
| 0.12% | 0.21% | #6 | $2.6M | 451,114 | $4.1M | 451,114 | 00.00% | Unchanged |
| Alyeska Investment Group, L.P. |
| 0.01% | 0.01% | #29 | $2.5M | 438,882 | $4.2M | 463,495 | -24,613-5.31% | Reduce |
| STATE STREET CORP |
| <0.01% | <0.01% | #95 | $2.3M | 406,674 | $3.7M | 402,225 | +4,449+1.11% | Add |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #46 | $1.6M | 285,584 | $4.6M | 500,997 | -215,413-43.00% | Reduce |
| Rock Springs Capital Management LP |
| 0.07% | 0.14% | #10 | $1.5M | 257,460 | $2.4M | 257,460 | 00.00% | Unchanged |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #88 | $1.5M | 255,410 | $5.0M | 547,534 | -292,124-53.35% | Reduce |
| DISCOVERY CAPITAL MANAGEMENT, LLC / CT |
| 0.06% | 0.11% | #11 | $1.4M | 241,300 | $2.2M | 241,300 | 00.00% | Unchanged |
| AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #58 | $1.3M | 227,732 | $1.3M | 140,305 | +87,427+62.31% | Add |
| Jefferies Financial Group Inc. |
| 0.01% | — | #27 | $1.1M | 200,300 | $0 | 0 | +200,300 | New Buy |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #103 | $1.1M | 193,323 | $1.4M | 153,004 | +40,319+26.35% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #81 | $1.1M | 187,144 | $1.7M | 185,624 | +1,520+0.82% | Add |
| SCOGGIN MANAGEMENT LP |
| 0.11% | 0.11% | #7 | $994,000 | 175,000 | $1.1M | 125,000 | +50,000+40.00% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #80 | $981,544 | 172,807 | $1.4M | 149,544 | +23,263+15.56% | Add |
| Susquehanna Portfolio Strategies, LLC |
| 0.01% | — | #21 | $875,021 | 154,053 | $0 | 0 | +154,053 | New Buy |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #93 | $855,743 | 150,659 | $1.7M | 183,756 | -33,097-18.01% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #72 | $848,819 | 149,440 | $1.4M | 149,987 | -547-0.36% | Reduce |
| OCCUDO QUANTITATIVE STRATEGIES LP |
| 0.04% | — | #13 | $831,416 | 146,376 | $0 | 0 | +146,376 | New Buy |
| Quantinno Capital Management LP |
| <0.01% | <0.01% | #51 | $782,221 | 137,715 | $435,979 | 47,648 | +90,067+189.03% | Add |
| XTX Topco Ltd |
| 0.01% | 0.04% | #24 | $741,950 | 130,625 | $2.0M | 221,037 | -90,412-40.90% | Reduce |
| Jump Financial, LLC |
| 0.01% | 0.01% | #31 | $637,194 | 112,182 | $916,830 | 100,200 | +11,982+11.96% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #91 | $635,166 | 111,825 | $1.4M | 156,989 | -45,164-28.77% | Reduce |
| Woodline Partners LP |
| <0.01% | <0.01% | #42 | $568,000 | 100,000 | $915,000 | 100,000 | 00.00% | Unchanged |
| Affinity Asset Advisors, LLC |
| 0.03% | 0.05% | #17 | $568,000 | 100,000 | $915,000 | 100,000 | 00.00% | Unchanged |
| MANGROVE PARTNERS IM, LLC |
| 0.04% | — | #14 | $549,534 | 96,749 | $0 | 0 | +96,749 | New Buy |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #104 | $548,688 | 96,600 | $387,960 | 42,400 | +54,200+127.83% | Add |
| Rockefeller Capital Management L.P. |
| <0.01% | <0.01% | #53 | $524,548 | 92,350 | $671,062 | 73,340 | +19,010+25.92% | Add |
| KBC Group NV |
| <0.01% | <0.01% | #48 | $513,614 | 90,425 | $827,000 | 90,425 | 00.00% | Unchanged |
| HSBC HOLDINGS PLC |
| <0.01% | <0.01% | #71 | $448,538 | 79,811 | $203,833 | 21,894 | +57,917+264.53% | Add |
| Corient Private Wealth LLC |
| <0.01% | <0.01% | #65 | $424,468 | 74,730 | $340,922 | 37,259 | +37,471+100.57% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #107 | $415,668 | 73,181 | $364,000 | 39,621 | +33,560+84.70% | Add |
| Y-Intercept (Hong Kong) Ltd |
| 0.01% | 0.03% | #25 | $401,735 | 70,728 | $1.5M | 158,715 | -87,987-55.44% | Reduce |
