| Jupiter Topco LLC |
| 0.02% | — | #26 | $55.9M | 20.7M | $0 | 0 | +20.7M | New Buy |
| EVENTIDE ASSET MANAGEMENT, LLC |
| 0.42% | 0.36% | #12 | $31.8M | 11.8M | $22.0M | 9.9M | +1.9M+19.11% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #60 | $29.1M | 10.8M | $3.4M | 1.5M | +9.3M+605.90% | Add |
| RA CAPITAL MANAGEMENT, L.P. |
| 0.25% | 0.25% | #14 | $28.2M | 10.5M | $23.8M | 10.7M | -213,032-1.99% | Reduce |
| Affinity Asset Advisors, LLC |
| 1.23% | 1.22% | #3 | $27.3M | 10.1M | $23.6M | 10.6M | -491,756-4.62% | Reduce |
| STATE STREET CORP |
| <0.01% | <0.01% | #53 | $21.3M | 7.9M | $1.2M | 520,283 | +7.4M+1,418.55% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #59 | $20.9M | 7.8M | $11.7M | 5.3M | +2.5M+47.58% | Add |
| ADAR1 Capital Management, LLC |
| 0.92% | 0.59% | #5 | $20.0M | 7.4M | $10.1M | 4.5M | +2.9M+63.23% | Add |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.02% | 0.02% | #27 | $18.1M | 6.7M | $12.3M | 5.5M | +1.2M+21.43% | Add |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.02% | 0.02% | #24 | $16.6M | 6.2M | $13.7M | 6.2M | 00.00% | Unchanged |
| FEDERATED HERMES, INC. |
| 0.02% | 0.01% | #25 | $16.0M | 6.0M | $7.9M | 3.6M | +2.4M+66.67% | Add |
| BRAIDWELL LP |
| 0.59% | — | #9 | $15.9M | 5.9M | $0 | 0 | +5.9M | New Buy |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #54 | $11.0M | 4.1M | $2.9M | 1.3M | +2.8M+208.98% | Add |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 0.87% | 0.23% | #6 | $8.3M | 3.1M | $2.2M | 1.0M | +2.1M+210.11% | Add |
| STEMPOINT CAPITAL LP |
| 0.93% | — | #4 | $6.5M | 2.4M | $0 | 0 | +2.4M | New Buy |
| Ikarian Capital, LLC |
| 0.65% | 0.52% | #8 | $6.1M | 2.3M | $6.4M | 2.9M | -625,000-21.59% | Reduce |
| Point72 Asset Management, L.P. |
| 0.01% | <0.01% | #35 | $5.2M | 1.9M | $2.9M | 1.3M | +625,117+47.34% | Add |
| SPHERA FUNDS MANAGEMENT LTD. |
| 0.48% | 0.57% | #10 | $3.6M | 1.4M | $3.6M | 1.6M | -269,828-16.63% | Reduce |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #63 | $3.4M | 1.2M | $565,665 | 254,804 | +991,335+389.06% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #52 | $3.1M | 1.1M | $1.5M | 693,256 | +447,497+64.55% | Add |
| Propel Bio Management, LLC |
| 1.57% | 1.28% | #1 | $3.0M | 1.1M | $2.0M | 921,457 | +194,081+21.06% | Add |
| Rosalind Advisors, Inc. |
| 0.71% | 0.99% | #7 | $3.0M | 1.1M | $2.5M | 1.1M | 00.00% | Unchanged |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #81 | $2.8M | 1.0M | $0 | 0 | +1.0M | New Buy |
| Sio Capital Management, LLC |
| 0.45% | 0.4% | #11 | $2.7M | 1.0M | $2.8M | 1.3M | -247,047-19.73% | Reduce |
| Ensign Peak Advisors, Inc |
| <0.01% | — | #39 | $2.7M | 988,084 | $0 | 0 | +988,084 | New Buy |
| Nuveen, LLC |
| <0.01% | — | #55 | $2.4M | 893,254 | $0 | 0 | +893,254 | New Buy |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #41 | $2.2M | 832,378 | $2.8M | 1.3M | -424,491-33.77% | Reduce |
| WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #64 | $2.2M | 826,206 | $1.6M | 713,625 | +112,581+15.78% | Add |
| ORBIMED ADVISORS LLC |
| 0.04% | — | #22 | $2.0M | 747,000 | $0 | 0 | +747,000 | New Buy |
| BOOTHBAY FUND MANAGEMENT, LLC |
| 0.03% | 0.03% | #23 | $2.0M | 737,758 | $2.1M | 927,913 | -190,155-20.49% | Reduce |
| Saturn V Capital Management LP |
| 0.26% | 1.68% | #13 | $1.8M | 663,060 | $9.2M | 4.2M | -3.5M-84.09% | Reduce |
| Ally Bridge Group (NY) LLC |
| 1.49% | 5.05% | #2 | $1.7M | 624,561 | $6.3M | 2.8M | -2.2M-77.84% | Reduce |
| UBS Group AG |
| <0.01% | <0.01% | #79 | $1.2M | 458,917 | $616,397 | 277,656 | +181,261+65.28% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #78 | $1.2M | 444,042 | $159,840 | 72,000 | +372,042+516.73% | Add |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #73 | $1.1M | 416,318 | $122,184 | 55,038 | +361,280+656.42% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #89 | $1.1M | 409,490 | $644,759 | 290,432 | +119,058+40.99% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | — | #72 | $1.0M | 387,767 | $0 | 0 | +387,767 | New Buy |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #88 | $894,942 | 332,692 | $339,320 | 152,847 | +179,845+117.66% | Add |
| Informed Momentum Co LLC |
| 0.06% | 0.07% | #19 | $698,407 | 259,631 | $600,062 | 270,298 | -10,667-3.95% | Reduce |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #98 | $692,406 | 257,400 | $4.8M | 2.2M | -1.9M-88.14% | Reduce |
| Atom Investors LP |
| 0.06% | — | #20 | $677,439 | 251,836 | $0 | 0 | +251,836 | New Buy |
| CIBC WORLD MARKET INC. |
| <0.01% | <0.01% | #48 | $588,709 | 218,851 | $553,559 | 249,351 | -30,500-12.23% | Reduce |
| Parkman Healthcare Partners LLC |
| 0.05% | 0.05% | #21 | $532,477 | 197,947 | $462,215 | 208,205 | -10,258-4.93% | Reduce |
| SEI INVESTMENTS CO |
| <0.01% | <0.01% | #57 | $529,083 | 196,685 | $730,211 | 328,924 | -132,239-40.20% | Reduce |
| CITIGROUP INC |
| <0.01% | <0.01% | #75 | $513,946 | 191,058 | $253,617 | 114,242 | +76,816+67.24% | Add |
| Invesco Ltd. |
| <0.01% | <0.01% | #104 | $470,481 | 174,900 | $225,510 | 101,581 | +73,319+72.18% | Add |
| RHUMBLINE ADVISERS |
| <0.01% | — | #65 | $457,666 | 170,139 | $0 | 0 | +170,139 | New Buy |
| AMERICAN CENTURY COMPANIES INC |
| <0.01% | — | #71 | $455,638 | 169,382 | $0 | 0 | +169,382 | New Buy |
| DEUTSCHE BANK AG\ |
| <0.01% | — | #83 | $401,862 | 149,391 | $0 | 0 | +149,391 | New Buy |
| Rafferty Asset Management, LLC |
| <0.01% | — | #50 | $367,922 | 136,774 | $0 | 0 | +136,774 | New Buy |
