| EVENTIDE ASSET MANAGEMENT, LLC |
| 1.31% | 0.99% | #6 | $98.1M | 6.3M | $59.6M | 5.9M | +308,185+5.18% | Add |
| Soleus Capital Management, L.P. |
| 2.37% | 1.77% | #5 | $68.8M | 4.4M | $43.6M | 4.4M | +39,213+0.90% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #36 | $66.9M | 4.3M | $74.7M | 3.8M | +505,239+13.43% | Add |
| Sands Capital Alternatives, LLC |
| 9.47% | 8.82% | #3 | $58.1M | 3.7M | $37.2M | 3.7M | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #55 | $52.3M | 3.3M | $30.4M | 3.0M | +301,576+9.92% | Add |
| Point72 Asset Management, L.P. |
| 0.04% | 0.03% | #23 | $35.3M | 2.3M | $25.3M | 2.5M | -270,357-10.71% | Reduce |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #66 | $27.9M | 1.8M | $17.3M | 1.7M | +54,369+3.15% | Add |
| Vestal Point Capital, LP |
| 0.59% | 0.62% | #9 | $25.1M | 1.6M | $22.2M | 2.2M | -611,518-27.65% | Reduce |
| RTW INVESTMENTS, LP |
| 0.2% | 0.2% | #15 | $23.5M | 1.5M | $20.0M | 2.0M | -500,000-25.00% | Reduce |
| DEERFIELD MANAGEMENT COMPANY, L.P. |
| 0.22% | 0.16% | #14 | $20.7M | 1.3M | $13.3M | 1.3M | 00.00% | Unchanged |
| Omega Fund Management, LLC |
| 11.11% | 8.08% | #2 | $20.6M | 1.3M | $13.2M | 1.3M | 00.00% | Unchanged |
| Eversept Partners, LP |
| 1.02% | 0.75% | #7 | $19.6M | 1.2M | $14.2M | 1.4M | -165,397-11.69% | Reduce |
| Divisadero Street Capital Management, LP |
| 0.4% | — | #10 | $17.5M | 1.1M | $0 | 0 | +1.1M | New Buy |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #54 | $16.8M | 1.1M | $9.3M | 932,678 | +140,774+15.09% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #73 | $15.2M | 970,192 | $9.5M | 946,087 | +24,105+2.55% | Add |
| MILLENNIUM MANAGEMENT LLC |
| 0.01% | <0.01% | #34 | $15.0M | 956,244 | $8.6M | 860,866 | +95,378+11.08% | Add |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.02% | 0.01% | #28 | $13.4M | 855,682 | $6.2M | 617,915 | +237,767+38.48% | Add |
| PERCEPTIVE ADVISORS LLC |
| 0.2% | 0.17% | #16 | $13.1M | 832,944 | $8.4M | 842,944 | -10,000-1.19% | Reduce |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #61 | $12.0M | 703,356 | $3.0M | 307,229 | +396,127+128.94% | Add |
| Bruce & Co., Inc. |
| 2.92% | 1.58% | #4 | $10.4M | 665,700 | $5.5M | 550,700 | +115,000+20.88% | Add |
| FARALLON CAPITAL MANAGEMENT, L.L.C. |
| 0.04% | 0.21% | #22 | $9.3M | 595,000 | $36.2M | 3.6M | -3.0M-83.51% | Reduce |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #68 | $8.6M | 546,650 | $1.4M | 136,215 | +410,435+301.31% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #58 | $8.4M | 537,105 | $1.2M | 121,334 | +415,771+342.67% | Add |
| Trexquant Investment LP |
| 0.05% | 0.02% | #21 | $7.7M | 494,435 | $2.4M | 241,601 | +252,834+104.65% | Add |
| Tri Locum Partners LP |
| 0.95% | — | #8 | $7.7M | 493,344 | $0 | 0 | +493,344 | New Buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND |
| 0.01% | 0.01% | #31 | $6.4M | 409,300 | $5.5M | 546,132 | -136,832-25.05% | Reduce |
| UBS Group AG |
| <0.01% | <0.01% | #56 | $6.1M | 386,623 | $6.2M | 623,253 | -236,630-37.97% | Reduce |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #57 | $5.5M | 350,873 | $3.2M | 322,467 | +28,406+8.81% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #65 | $5.2M | 331,956 | $3.0M | 295,818 | +36,138+12.22% | Add |
| AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #45 | $4.8M | 308,468 | $604,075 | 60,287 | +248,181+411.67% | Add |
| Granahan Investment Management, LLC |
| 0.17% | 0.12% | #18 | $4.7M | 299,632 | $2.5M | 248,449 | +51,183+20.60% | Add |
| PURA VIDA INVESTMENTS, LLC |
| 11.91% | 18.94% | #1 | $4.4M | 281,164 | $2.8M | 281,250 | -86-0.03% | Reduce |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #88 | $4.3M | 272,984 | $2.3M | 229,042 | +43,942+19.19% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #53 | $4.2M | 267,915 | $2.7M | 272,086 | -4,171-1.53% | Reduce |
| Mariner, LLC |
| <0.01% | — | #35 | $3.5M | 220,359 | $0 | 0 | +220,359 | New Buy |
| Jain Global LLC |
| 0.01% | <0.01% | #29 | $2.7M | 172,584 | $567,292 | 56,616 | +115,968+204.83% | Add |
| Squarepoint Ops LLC |
| <0.01% | — | #39 | $2.5M | 161,098 | $0 | 0 | +161,098 | New Buy |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #78 | $1.9M | 122,897 | $990,017 | 98,804 | +24,093+24.38% | Add |
| LAZARD ASSET MANAGEMENT LLC |
| <0.01% | <0.01% | #42 | $1.5M | 95,554 | $720,488 | 71,905 | +23,649+32.89% | Add |
| Nuveen, LLC |
| <0.01% | <0.01% | #77 | $1.4M | 91,371 | $860,998 | 85,928 | +5,443+6.33% | Add |
| CITIGROUP INC |
| <0.01% | <0.01% | #76 | $1.2M | 74,055 | $20,170 | 2,013 | +72,042+3,578.84% | Add |
| Bellevue Group AG |
| 0.02% | 0.02% | #25 | $1.1M | 72,152 | $722,963 | 72,152 | 00.00% | Unchanged |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
| <0.01% | <0.01% | #49 | $1.1M | 69,959 | $713,534 | 71,211 | -1,252-1.76% | Reduce |
| TUDOR INVESTMENT CORP ET AL |
| <0.01% | <0.01% | #48 | $999,887 | 63,809 | $2.2M | 218,094 | -154,285-70.74% | Reduce |
| Y-Intercept (Hong Kong) Ltd |
| 0.02% | 0.09% | #27 | $987,821 | 63,039 | $4.9M | 485,854 | -422,815-87.03% | Reduce |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #106 | $902,592 | 57,600 | $190,380 | 19,000 | +38,600+203.16% | Add |
| Archon Capital Management LLC |
| 0.34% | — | #12 | $844,190 | 53,873 | $0 | 0 | +53,873 | New Buy |
| RHUMBLINE ADVISERS |
| <0.01% | <0.01% | #64 | $803,141 | 51,254 | $465,219 | 46,430 | +4,824+10.39% | Add |
| Values First Advisors, Inc. |
| 0.36% | 0.25% | #11 | $797,600 | 50,900 | $476,458 | 47,551 | +3,349+7.04% | Add |
| DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #86 | $755,639 | 48,222 | $437,883 | 43,701 | +4,521+10.35% | Add |
