| RA CAPITAL MANAGEMENT, L.P. |
| 3.39% | 4.95% | #7 | $389.6M | 12.2M | $467.2M | 12.2M | 00.00% | Unchanged |
| FMR LLC |
| 0.01% | 0.02% | #47 | $284.9M | 8.9M | $296.7M | 7.7M | +1.2M+15.14% | Add |
| Jupiter Topco LLC |
| 0.06% | — | #28 | $139.2M | 4.4M | $0 | 0 | +4.4M | New Buy |
| Alta Partners Management Company, L.P. |
| 95.92% | 96.97% | #1 | $122.1M | 3.8M | $146.4M | 3.8M | 00.00% | Unchanged |
| Nextech Invest Ltd. |
| 5.41% | 10.93% | #4 | $113.5M | 3.6M | $155.3M | 4.1M | -502,276-12.38% | Reduce |
| TCG Crossover Management, LLC |
| 2.49% | 3.56% | #9 | $103.8M | 3.2M | $124.4M | 3.2M | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #85 | $96.8M | 3.0M | $84.9M | 2.2M | +814,043+36.70% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.01% | <0.01% | #53 | $88.9M | 2.8M | $37.8M | 986,061 | +1.8M+182.19% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #78 | $68.4M | 2.1M | $46.6M | 1.2M | +924,290+76.01% | Add |
| Commodore Capital LP |
| 3.57% | 5.48% | #6 | $59.9M | 1.9M | $94.8M | 2.5M | -600,000-24.24% | Reduce |
| Paradigm Biocapital Advisors LP |
| 1.09% | 1.61% | #16 | $58.4M | 1.8M | $78.7M | 2.1M | -226,384-11.02% | Reduce |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #96 | $48.2M | 1.5M | $43.1M | 1.1M | +382,477+33.97% | Add |
| BVF INC/IL |
| 1.21% | 2.41% | #14 | $47.1M | 1.5M | $75.7M | 2.0M | -500,000-25.30% | Reduce |
| 5AM Venture Management, LLC |
| 11.42% | 10.94% | #3 | $32.9M | 1.0M | $39.4M | 1.0M | 00.00% | Unchanged |
| DEERFIELD MANAGEMENT COMPANY, L.P. |
| 0.34% | 0.25% | #18 | $32.5M | 1.0M | $21.0M | 549,000 | +468,000+85.25% | Add |
| Hood River Capital Management LLC |
| 0.24% | — | #20 | $32.5M | 1.0M | $0 | 0 | +1.0M | New Buy |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #81 | $31.0M | 970,734 | $25.2M | 658,482 | +312,252+47.42% | Add |
| Caligan Partners LP |
| 1.21% | 3.25% | #13 | $25.8M | 806,986 | $48.9M | 1.3M | -469,982-36.80% | Reduce |
| Canaan Partners XI LLC |
| 18.82% | 37.76% | #2 | $24.0M | 750,000 | $28.7M | 750,000 | 00.00% | Unchanged |
| Siren, L.L.C. |
| 0.47% | — | #17 | $23.2M | 725,000 | $0 | 0 | +725,000 | New Buy |
| Sio Capital Management, LLC |
| 3.68% | 3.33% | #5 | $22.2M | 695,315 | $23.2M | 605,439 | +89,876+14.84% | Add |
| STEMPOINT CAPITAL LP |
| 2.88% | 1.42% | #8 | $20.2M | 632,754 | $7.7M | 293,177 | +339,577+115.83% | Add |
| MARSHALL WACE, LLP |
| 0.01% | 0.01% | #45 | $18.6M | 583,133 | $7.6M | 197,748 | +385,385+194.89% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #87 | $14.8M | 463,477 | $21.1M | 550,334 | -86,857-15.78% | Reduce |
| JENNISON ASSOCIATES LLC |
| 0.01% | 0.02% | #54 | $14.4M | 450,964 | $24.2M | 632,432 | -181,468-28.69% | Reduce |
| TWO SIGMA INVESTMENTS, LP |
| 0.01% | <0.01% | #50 | $14.4M | 449,808 | $3.9M | 101,618 | +348,190+342.65% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #112 | $12.9M | 403,019 | $9.5M | 247,270 | +155,749+62.99% | Add |
| Defilade Capital Management, L.P. |
| 1.61% | — | #11 | $12.0M | 376,870 | $0 | 0 | +376,870 | New Buy |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #105 | $11.2M | 349,732 | $8.0M | 209,922 | +139,810+66.60% | Add |
| Walleye Capital LLC |
| 0.04% | <0.01% | #33 | $11.1M | 347,898 | $716,785 | 18,715 | +329,183+1,758.93% | Add |
| Woodline Partners LP |
| 0.03% | 0.04% | #36 | $10.2M | 320,040 | $11.5M | 301,040 | +19,000+6.31% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #91 | $9.9M | 310,084 | $8.4M | 218,508 | +91,576+41.91% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #120 | $9.6M | 300,322 | $4.5M | 322,143 | -21,821-6.77% | Reduce |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #102 | $9.6M | 299,500 | $2.6M | 68,243 | +231,257+338.87% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #97 | $8.9M | 278,307 | $1.8M | 47,796 | +230,511+482.28% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #92 | $8.6M | 267,699 | $7.6M | 199,111 | +68,588+34.45% | Add |
| Qube Research & Technologies Ltd |
| 0.01% | — | #57 | $8.5M | 266,934 | $0 | 0 | +266,934 | New Buy |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #63 | $7.7M | 240,227 | $7.3M | 190,039 | +50,188+26.41% | Add |
| ALGERT GLOBAL LLC |
| 0.09% | 0.11% | #23 | $7.6M | 239,120 | $7.2M | 188,010 | +51,110+27.18% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #83 | $7.2M | 224,805 | $6.0M | 157,791 | +67,014+42.47% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #88 | $6.9M | 217,078 | $3.5M | 91,826 | +125,252+136.40% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #76 | $6.5M | 202,672 | $10.0M | 261,581 | -58,909-22.52% | Reduce |
| Affinity Asset Advisors, LLC |
| 0.29% | 0.51% | #19 | $6.4M | 200,012 | $9.9M | 257,512 | -57,500-22.33% | Reduce |
| FRANKLIN RESOURCES INC |
| <0.01% | <0.01% | #89 | $6.1M | 192,340 | $496,751 | 12,970 | +179,370+1,382.96% | Add |
| HighVista Strategies LLC |
| 1.35% | 1.39% | #12 | $5.9M | 184,774 | $5.0M | 131,304 | +53,470+40.72% | Add |
| RAYMOND JAMES FINANCIAL INC |
| <0.01% | <0.01% | #84 | $5.8M | 180,881 | $9.5M | 247,098 | -66,217-26.80% | Reduce |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #129 | $5.7M | 178,263 | $2.3M | 66,789 | +111,474+166.90% | Add |
| BOOTHBAY FUND MANAGEMENT, LLC |
| 0.07% | 0.14% | #26 | $5.5M | 173,559 | $10.5M | 273,274 | -99,715-36.49% | Reduce |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.01% | — | #60 | $5.2M | 162,000 | $0 | 0 | +162,000 | New Buy |
| Jump Financial, LLC |
| 0.04% | 0.02% | #32 | $5.0M | 157,000 | $1.6M | 41,375 | +115,625+279.46% | Add |
