| BlackRock, Inc. |
| <0.01% | <0.01% | #107 | $137.2M | 4.8M | $78.5M | 4.5M | +292,613+6.47% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #104 | $70.4M | 2.5M | $47.9M | 2.8M | -291,527-10.56% | Reduce |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #122 | $62.6M | 2.2M | $37.5M | 2.2M | +37,018+1.71% | Add |
| DEERFIELD MANAGEMENT COMPANY, L.P. |
| 0.59% | 0.45% | #11 | $56.9M | 2.0M | $38.0M | 2.2M | -193,382-8.83% | Reduce |
| ARK Investment Management LLC |
| 0.36% | 0.3% | #20 | $55.7M | 2.0M | $38.7M | 2.2M | -274,025-12.30% | Reduce |
| Boston Partners |
| 0.05% | 0.03% | #39 | $55.2M | 1.9M | $32.7M | 1.9M | +54,067+2.87% | Add |
| BAMCO INC /NY/ |
| 0.08% | 0.17% | #37 | $55.2M | 1.9M | $57.9M | 3.3M | -1.4M-41.93% | Reduce |
| GAGNON SECURITIES LLC |
| 9.81% | 7.06% | #3 | $50.5M | 1.8M | $30.6M | 1.8M | +8,861+0.50% | Add |
| Chevy Chase Trust Holdings, LLC |
| 0.11% | 0.08% | #31 | $41.0M | 1.4M | $26.1M | 1.5M | -66,659-4.43% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #108 | $37.9M | 1.3M | $21.8M | 1.3M | +73,923+5.89% | Add |
| Ophir Asset Management Pty Ltd |
| 2.96% | 2% | #4 | $36.0M | 1.3M | $17.2M | 988,051 | +276,758+28.01% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| 0.05% | 0.03% | #40 | $35.4M | 1.2M | $20.6M | 1.2M | +58,561+4.94% | Add |
| BRAIDWELL LP |
| 1.29% | 1.26% | #7 | $34.8M | 1.2M | $37.7M | 2.2M | -952,544-43.83% | Reduce |
| Sumitomo Mitsui Trust Group, Inc. |
| 0.02% | 0.02% | #51 | $34.0M | 1.2M | $25.6M | 1.5M | -283,496-19.22% | Reduce |
| Blue Water Life Science Advisors, LP |
| 21.36% | 13.02% | #1 | $33.9M | 1.2M | $16.2M | 935,000 | +255,000+27.27% | Add |
| Amova Asset Management Americas, Inc. |
| 0.44% | 0.36% | #17 | $33.8M | 1.2M | $25.6M | 1.5M | -287,051-19.46% | Reduce |
| DIMENSIONAL FUND ADVISORS LP |
| 0.01% | 0.01% | #74 | $33.7M | 1.2M | $25.4M | 1.5M | -280,837-19.21% | Reduce |
| D. E. Shaw & Co., Inc. |
| 0.02% | 0.01% | #54 | $32.4M | 1.1M | $15.2M | 874,908 | +262,752+30.03% | Add |
| JACOBS LEVY EQUITY MANAGEMENT, INC |
| 0.1% | 0.06% | #32 | $28.4M | 995,669 | $15.0M | 864,468 | +131,201+15.18% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #124 | $28.2M | 989,529 | $14.8M | 851,433 | +138,096+16.22% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #128 | $22.1M | 774,299 | $7.1M | 486,299 | +288,000+59.22% | Add |
| Divisadero Street Capital Management, LP |
| 0.45% | — | #16 | $20.0M | 700,938 | $0 | 0 | +700,938 | New Buy |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #112 | $19.9M | 699,993 | $12.7M | 733,332 | -33,339-4.55% | Reduce |
| Portolan Capital Management, LLC |
| 0.73% | 0.31% | #10 | $19.5M | 684,805 | $5.9M | 340,352 | +344,453+101.20% | Add |
| First Eagle Investment Management, LLC |
| 0.03% | 0.02% | #47 | $17.1M | 598,497 | $10.0M | 575,365 | +23,132+4.02% | Add |
| ROYCE & ASSOCIATES LP |
| 0.13% | 0.09% | #25 | $16.4M | 575,971 | $9.6M | 553,197 | +22,774+4.12% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #133 | $16.3M | 571,808 | $8.2M | 470,665 | +101,143+21.49% | Add |
| Gagnon Advisors, LLC |
| 9.91% | 6.81% | #2 | $15.6M | 546,893 | $9.3M | 532,892 | +14,001+2.63% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #106 | $15.3M | 538,125 | $8.9M | 510,405 | +27,720+5.43% | Add |
| Palo Alto Investors LP |
| 2.22% | 1.41% | #6 | $15.2M | 531,870 | $9.2M | 531,870 | 00.00% | Unchanged |
| Russell Investments Group, Ltd. |
| 0.01% | 0.01% | #60 | $14.6M | 513,550 | $9.7M | 558,336 | -44,786-8.02% | Reduce |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #130 | $13.7M | 479,873 | $4.3M | 250,351 | +229,522+91.68% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #116 | $13.6M | 478,798 | $7.9M | 454,508 | +24,290+5.34% | Add |
| Meridiem Capital Partners LP |
| 0.58% | 0.36% | #13 | $12.9M | 451,493 | $5.5M | 316,950 | +134,543+42.45% | Add |
| Invesco Ltd. |
| <0.01% | <0.01% | #136 | $12.7M | 447,205 | $8.4M | 484,938 | -37,733-7.78% | Reduce |
| TWO SIGMA INVESTMENTS, LP |
| 0.01% | <0.01% | #68 | $11.5M | 401,987 | $4.0M | 231,600 | +170,387+73.57% | Add |
| Zweig-DiMenna Associates LLC |
| 1.01% | 0.94% | #8 | $11.1M | 388,812 | $6.8M | 390,255 | -1,443-0.37% | Reduce |
| BNP PARIBAS FINANCIAL MARKETS |
| 0.01% | <0.01% | #78 | $10.7M | 374,909 | $8.0M | 458,301 | -83,392-18.20% | Reduce |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
| <0.01% | — | #83 | $10.6M | 372,111 | $0 | 0 | +372,111 | New Buy |
| Qube Research & Technologies Ltd |
| 0.01% | — | #65 | $10.5M | 369,837 | $0 | 0 | +369,837 | New Buy |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #102 | $10.4M | 366,541 | $6.1M | 352,466 | +14,075+3.99% | Add |
| Jupiter Topco LLC |
| <0.01% | — | #87 | $9.7M | 339,418 | $0 | 0 | +339,418 | New Buy |
| ArrowMark Colorado Holdings LLC |
| 0.4% | 0.22% | #19 | $9.6M | 338,549 | $8.4M | 486,668 | -148,119-30.44% | Reduce |
| SILVERCREST ASSET MANAGEMENT GROUP LLC |
| 0.06% | 0.04% | #38 | $8.4M | 296,200 | $5.4M | 310,539 | -14,339-4.62% | Reduce |
| Connor, Clark & Lunn Investment Management Ltd. |
| 0.01% | 0.01% | #56 | $7.6M | 268,207 | $6.4M | 370,183 | -101,976-27.55% | Reduce |
| FMR LLC |
| <0.01% | <0.01% | #171 | $7.2M | 253,314 | $4.0M | 231,305 | +22,009+9.52% | Add |
| AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #100 | $7.0M | 244,375 | $6.1M | 349,225 | -104,850-30.02% | Reduce |
| Aberdeen Group plc |
| 0.01% | 0.01% | #66 | $6.4M | 224,829 | $7.3M | 417,744 | -192,915-46.18% | Reduce |
| ExodusPoint Capital Management, LP |
| 0.04% | — | #44 | $6.1M | 214,342 | $0 | 0 | +214,342 | New Buy |
| Legal & General Group Plc |
| <0.01% | <0.01% | #125 | $6.0M | 211,967 | $3.6M | 209,763 | +2,204+1.05% | Add |
