| BlackRock, Inc. |
| <0.01% | <0.01% | #101 | $239.6M | 6.5M | $194.7M | 5.8M | +701,040+12.18% | Add |
| FARALLON CAPITAL MANAGEMENT, L.L.C. |
| 1.01% | 1.1% | #12 | $219.6M | 5.9M | $192.3M | 5.7M | +233,400+4.11% | Add |
| ARMISTICE CAPITAL, LLC |
| 2.37% | 3.56% | #6 | $193.3M | 5.2M | $200.1M | 5.9M | -706,000-11.93% | Reduce |
| STATE STREET CORP |
| <0.01% | <0.01% | #97 | $131.1M | 3.5M | $113.7M | 3.4M | +168,754+5.02% | Add |
| Lynx1 Capital Management LP |
| 24.92% | 13.96% | #1 | $126.5M | 3.4M | $88.3M | 2.6M | +797,369+30.53% | Add |
| D. E. Shaw & Co., Inc. |
| 0.05% | 0.05% | #37 | $115.3M | 3.1M | $90.7M | 2.7M | +425,836+15.88% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #89 | $107.6M | 2.9M | $88.3M | 2.6M | +287,162+11.00% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #126 | $99.5M | 2.7M | $89.1M | 2.6M | +49,529+1.88% | Add |
| Erste Asset Management GmbH |
| 0.64% | 0.74% | #14 | $82.0M | 2.2M | $80.1M | 2.7M | -550,000-20.33% | Reduce |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. |
| 0.12% | 0.09% | #26 | $78.3M | 2.1M | $50.6M | 1.5M | +616,374+41.24% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | 0.01% | #87 | $62.5M | 1.7M | $52.7M | 1.6M | +126,805+8.15% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #108 | $58.4M | 1.6M | $49.7M | 1.5M | +106,358+7.25% | Add |
| ADAR1 Capital Management, LLC |
| 2.2% | 0.28% | #7 | $47.8M | 1.3M | $4.8M | 140,672 | +1.1M+815.64% | Add |
| BNP Paribas Asset Management Holding S.A. |
| 0.05% | — | #42 | $47.5M | 1.3M | $0 | 0 | +1.3M | New Buy |
| DIMENSIONAL FUND ADVISORS LP |
| 0.01% | 0.01% | #74 | $46.3M | 1.2M | $38.9M | 1.2M | +97,124+8.43% | Add |
| GW&K Investment Management, LLC |
| 0.35% | 0.36% | #16 | $44.8M | 1.2M | $41.1M | 1.2M | -8,286-0.68% | Reduce |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #99 | $42.7M | 1.2M | $27.7M | 817,676 | +333,256+40.76% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #93 | $36.6M | 985,831 | $4.5M | 132,540 | +853,291+643.80% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #133 | $35.7M | 963,256 | $16.7M | 416,998 | +546,258+131.00% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #98 | $33.9M | 913,187 | $26.0M | 769,413 | +143,774+18.69% | Add |
| Nuveen, LLC |
| 0.01% | 0.01% | #75 | $32.4M | 873,560 | $24.4M | 722,348 | +151,212+20.93% | Add |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
| 0.01% | <0.01% | #66 | $30.1M | 810,530 | $8.5M | 250,461 | +560,069+223.62% | Add |
| Foresite Capital Management VI LLC |
| 4.53% | 3.86% | #2 | $29.1M | 785,000 | $17.8M | 525,000 | +260,000+49.52% | Add |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #119 | $27.7M | 746,598 | $28.5M | 841,440 | -94,842-11.27% | Reduce |
| AQR CAPITAL MANAGEMENT LLC |
| 0.01% | <0.01% | #73 | $25.4M | 684,340 | $1.2M | 36,410 | +647,930+1,779.54% | Add |
| Parkman Healthcare Partners LLC |
| 2.54% | 1.41% | #5 | $24.8M | 669,046 | $13.7M | 403,525 | +265,521+65.80% | Add |
| SCS Capital Management LLC |
| 0.21% | 0.22% | #21 | $22.7M | 612,850 | $20.7M | 612,850 | 00.00% | Unchanged |
| Qube Research & Technologies Ltd |
| 0.02% | 0.01% | #54 | $22.2M | 597,638 | $6.3M | 187,667 | +409,971+218.46% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #118 | $20.6M | 554,709 | $17.2M | 509,272 | +45,437+8.92% | Add |
| Defilade Capital Management, L.P. |
| 2.72% | — | #4 | $20.3M | 546,848 | $0 | 0 | +546,848 | New Buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #114 | $20.0M | 538,128 | $16.1M | 477,032 | +61,096+12.81% | Add |
| TWO SIGMA INVESTMENTS, LP |
| 0.01% | 0.01% | #62 | $19.9M | 536,380 | $8.5M | 251,636 | +284,744+113.16% | Add |
| Rock Springs Capital Management LP |
| 0.96% | 1.59% | #13 | $19.8M | 532,563 | $27.0M | 799,163 | -266,600-33.36% | Reduce |
| Schonfeld Strategic Advisors LLC |
| 0.07% | 0.05% | #34 | $19.3M | 520,083 | $6.8M | 200,061 | +320,022+159.96% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #149 | $18.8M | 507,869 | $17.2M | 507,900 | -31-0.01% | Reduce |
| Point72 Asset Management, L.P. |
| 0.02% | <0.01% | #53 | $18.8M | 506,344 | $994,602 | 29,400 | +476,944+1,622.26% | Add |
| Legal & General Group Plc |
| <0.01% | <0.01% | #104 | $16.1M | 434,719 | $14.3M | 423,915 | +10,804+2.55% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #107 | $14.7M | 395,868 | $12.9M | 382,021 | +13,847+3.62% | Add |
| PANAGORA ASSET MANAGEMENT INC |
| 0.04% | 0.03% | #43 | $13.9M | 373,931 | $8.1M | 238,468 | +135,463+56.81% | Add |
| KENNEDY CAPITAL MANAGEMENT LLC |
| 0.25% | 0.2% | #20 | $13.9M | 373,230 | $9.3M | 275,456 | +97,774+35.50% | Add |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #165 | $13.8M | 359,756 | $4.5M | 151,558 | +208,198+137.37% | Add |
| Connor, Clark & Lunn Investment Management Ltd. |
| 0.03% | 0.04% | #50 | $13.3M | 359,550 | $15.2M | 450,093 | -90,543-20.12% | Reduce |
| Squarepoint Ops LLC |
| 0.01% | 0.01% | #67 | $11.9M | 321,138 | $7.1M | 208,888 | +112,250+53.74% | Add |
| Ensign Peak Advisors, Inc |
| 0.02% | <0.01% | #57 | $11.0M | 297,630 | $222,263 | 6,570 | +291,060+4,430.14% | Add |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | 0.01% | #91 | $10.0M | 269,383 | $11.1M | 327,457 | -58,074-17.73% | Reduce |
| Tetragon Partners GP Ltd |
| 1.49% | 1.08% | #10 | $9.5M | 255,579 | $5.6M | 164,839 | +90,740+55.05% | Add |
| ALGERT GLOBAL LLC |
| 0.11% | 0.14% | #28 | $9.2M | 248,007 | $9.1M | 268,435 | -20,428-7.61% | Reduce |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #163 | $8.1M | 218,966 | $10.1M | 298,783 | -79,817-26.71% | Reduce |
| Palo Alto Investors LP |
| 1.16% | 1.11% | #11 | $7.9M | 213,601 | $7.2M | 213,601 | 00.00% | Unchanged |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #148 | $7.4M | 198,685 | $6.3M | 186,791 | +11,894+6.37% | Add |
