| Frazier Life Sciences Management, L.P. |
| 13.35% | 13.96% | #3 | $613.0M | 18.1M | $542.4M | 16.9M | +1.1M+6.76% | Add |
| Capital World Investors |
| 0.05% | 0.05% | #61 | $414.5M | 12.2M | $355.6M | 11.1M | +1.1M+10.10% | Add |
| FMR LLC |
| 0.02% | 0.01% | #78 | $350.4M | 10.3M | $280.6M | 8.8M | +1.6M+17.95% | Add |
| RA CAPITAL MANAGEMENT, L.P. |
| 2.81% | 3.24% | #6 | $323.7M | 9.6M | $305.7M | 9.6M | 00.00% | Unchanged |
| FCPM III SERVICES B.V. |
| 38.34% | 40.77% | #2 | $287.7M | 8.5M | $294.5M | 9.2M | -708,547-7.70% | Reduce |
| DEERFIELD MANAGEMENT COMPANY, L.P. |
| 1.51% | 1.61% | #10 | $144.5M | 4.3M | $136.5M | 4.3M | 00.00% | Unchanged |
| VIKING GLOBAL INVESTORS LP |
| 0.41% | 0.38% | #24 | $142.5M | 4.2M | $134.6M | 4.2M | 00.00% | Unchanged |
| Bain Capital Life Sciences Investors, LLC |
| 7.67% | 21.09% | #4 | $129.0M | 3.8M | $233.9M | 7.3M | -3.5M-47.90% | Reduce |
| MAVERICK CAPITAL LTD |
| 0.98% | 0.81% | #13 | $110.7M | 3.3M | $70.0M | 2.2M | +1.1M+49.46% | Add |
| Duquesne Family Office LLC |
| 2% | 2.91% | #9 | $104.0M | 3.1M | $98.3M | 3.1M | 00.00% | Unchanged |
| Jupiter Topco LLC |
| 0.04% | — | #66 | $86.0M | 2.5M | $0 | 0 | +2.5M | New Buy |
| Medicxi Ventures Management (Jersey) Ltd |
| 42.19% | 8.72% | #1 | $74.9M | 2.2M | $85.6M | 2.7M | -465,543-17.41% | Reduce |
| JENNISON ASSOCIATES LLC |
| 0.04% | 0.06% | #63 | $71.2M | 2.1M | $88.0M | 2.8M | -648,117-23.56% | Reduce |
| Orbis Allan Gray Ltd |
| 0.2% | — | #37 | $59.2M | 1.7M | $0 | 0 | +1.7M | New Buy |
| Polar Capital Holdings Plc |
| 0.14% | 0.32% | #46 | $58.4M | 1.7M | $90.6M | 2.8M | -1.1M-39.10% | Reduce |
| Capital International Investors |
| 0.01% | 0.01% | #85 | $58.4M | 1.7M | $46.1M | 1.4M | +282,364+19.59% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | 0.01% | #98 | $52.9M | 1.6M | $62.3M | 1.9M | -384,463-19.75% | Reduce |
| WESTFIELD CAPITAL MANAGEMENT CO LP |
| 0.17% | 0.3% | #41 | $52.1M | 1.5M | $70.5M | 2.2M | -666,441-30.25% | Reduce |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #104 | $49.8M | 1.5M | $14.9M | 465,425 | +1.0M+216.04% | Add |
| Castle Hook Partners LP |
| 0.21% | 0.67% | #36 | $46.5M | 1.4M | $33.4M | 1.0M | +328,368+31.49% | Add |
| AMERIPRISE FINANCIAL INC |
| 0.01% | 0.01% | #91 | $42.5M | 1.3M | $24.1M | 753,054 | +500,495+66.46% | Add |
| ALLIANCEBERNSTEIN L.P. |
| 0.01% | 0.01% | #80 | $40.3M | 1.3M | $42.1M | 1.2M | +60,615+5.05% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | — | #103 | $39.6M | 1.2M | $0 | 0 | +1.2M | New Buy |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #120 | $38.4M | 1.1M | $25.9M | 884,228 | +248,727+28.13% | Add |
| Aberdeen Group plc |
| 0.05% | 0.04% | #59 | $37.4M | 1.1M | $26.8M | 837,005 | +265,780+31.75% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #155 | $36.1M | 1.1M | $28.4M | 886,616 | +177,134+19.98% | Add |
| FRANKLIN RESOURCES INC |
| 0.01% | 0.01% | #94 | $33.7M | 993,917 | $24.7M | 770,160 | +223,757+29.05% | Add |
| TimesSquare Capital Management, LLC |
| 0.4% | 0.41% | #26 | $27.0M | 796,162 | $24.1M | 751,988 | +44,174+5.87% | Add |
| BNP Paribas Asset Management Holding S.A. |
| 0.03% | — | #71 | $26.5M | 781,140 | $0 | 0 | +781,140 | New Buy |
| Woodline Partners LP |
| 0.08% | 0.09% | #50 | $25.5M | 752,489 | $24.1M | 752,308 | +181+0.02% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #130 | $24.9M | 735,483 | $27.1M | 847,089 | -111,606-13.18% | Reduce |
| Jefferies Financial Group Inc. |
| 0.16% | — | #44 | $24.5M | 722,728 | $0 | 0 | +722,728 | New Buy |
| NWI MANAGEMENT LP |
| 1.1% | 1.14% | #12 | $23.8M | 702,000 | $24.6M | 702,000 | 00.00% | Unchanged |
| AMERICAN CENTURY COMPANIES INC |
| 0.01% | 0.01% | #89 | $23.2M | 684,813 | $16.6M | 519,455 | +165,358+31.83% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #114 | $23.2M | 684,205 | $24.6M | 767,064 | -82,859-10.80% | Reduce |
| Rock Springs Capital Management LP |
| 0.96% | 1.11% | #14 | $19.7M | 582,744 | $18.8M | 588,794 | -6,050-1.03% | Reduce |
| First Turn Management, LLC |
| 2.11% | 2% | #8 | $19.7M | 582,497 | $17.9M | 558,336 | +24,161+4.33% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #142 | $19.5M | 575,825 | $42.6M | 1.5M | -921,654-61.55% | Reduce |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.03% | 0.05% | #72 | $18.6M | 550,000 | $35.4M | 1.1M | -556,631-50.30% | Reduce |
| Artia Global Partners LP |
| 3.15% | 3.23% | #5 | $17.1M | 503,936 | $16.1M | 503,936 | 00.00% | Unchanged |
| MILLENNIUM MANAGEMENT LLC |
| 0.01% | <0.01% | #95 | $17.0M | 501,614 | $9.7M | 303,848 | +197,766+65.09% | Add |
| PERCEPTIVE ADVISORS LLC |
| 0.25% | — | #31 | $16.9M | 500,000 | $0 | 0 | +500,000 | New Buy |
| Cormorant Asset Management, LP |
| 0.86% | 1.53% | #16 | $16.9M | 500,000 | $30.4M | 950,000 | -450,000-47.37% | Reduce |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #137 | $16.7M | 493,536 | $7.2M | 224,701 | +268,835+119.64% | Add |
| KENNEDY CAPITAL MANAGEMENT LLC |
| 0.25% | 0.28% | #32 | $14.3M | 421,374 | $13.1M | 408,492 | +12,882+3.15% | Add |
| Ikarian Capital, LLC |
| 1.44% | — | #11 | $13.6M | 400,000 | $0 | 0 | +400,000 | New Buy |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #126 | $12.0M | 353,298 | $12.1M | 378,800 | -25,502-6.73% | Reduce |
| HRT FINANCIAL LP |
| 0.02% | — | #73 | $11.9M | 349,843 | $0 | 0 | +349,843 | New Buy |
| UBS Group AG |
| <0.01% | <0.01% | #133 | $11.7M | 344,065 | $25.4M | 794,976 | -450,911-56.72% | Reduce |
| Slate Path Capital LP |
| 0.15% | 0.15% | #45 | $10.8M | 319,000 | $10.2M | 319,000 | 00.00% | Unchanged |
