| ARK Investment Management LLC |
| 1.85% | 1.45% | #3 | $285.5M | 16.9M | $186.0M | 14.5M | +2.4M+16.31% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #131 | $260.7M | 15.4M | $155.8M | 12.2M | +3.3M+26.76% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #124 | $156.3M | 9.2M | $88.7M | 6.9M | +2.3M+33.40% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.01% | <0.01% | #116 | $124.1M | 7.3M | $79.8M | 6.2M | +1.1M+17.82% | Add |
| D. E. Shaw & Co., Inc. |
| 0.05% | 0.04% | #52 | $109.0M | 6.4M | $73.4M | 5.7M | +715,146+12.48% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #167 | $102.0M | 6.0M | $65.2M | 5.1M | +944,481+18.58% | Add |
| TWO SIGMA INVESTMENTS, LP |
| 0.06% | 0.05% | #45 | $88.6M | 5.2M | $60.3M | 4.7M | +529,447+11.25% | Add |
| FMR LLC |
| <0.01% | <0.01% | #138 | $80.8M | 4.8M | $26.5M | 2.1M | +2.7M+130.89% | Add |
| RA CAPITAL MANAGEMENT, L.P. |
| 0.67% | — | #11 | $76.6M | 4.5M | $0 | 0 | +4.5M | New Buy |
| REGENERON PHARMACEUTICALS, INC. |
| 35.35% | 99.14% | #1 | $62.7M | 3.7M | $47.5M | 3.7M | 00.00% | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #143 | $61.4M | 3.6M | $36.6M | 2.9M | +779,589+27.34% | Add |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
| 0.02% | 0.01% | #76 | $55.5M | 3.3M | $17.9M | 1.4M | +1.9M+134.80% | Add |
| Sumitomo Mitsui Trust Group, Inc. |
| 0.03% | 0.02% | #72 | $49.0M | 2.9M | $25.3M | 2.0M | +924,468+46.85% | Add |
| Amova Asset Management Americas, Inc. |
| 0.63% | 0.36% | #12 | $49.0M | 2.9M | $25.3M | 2.0M | +924,468+46.85% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| 0.01% | 0.01% | #104 | $44.0M | 2.6M | $29.7M | 2.3M | +284,834+12.29% | Add |
| UBS Group AG |
| 0.01% | 0.01% | #118 | $41.4M | 2.4M | $41.8M | 3.3M | -811,758-24.91% | Reduce |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #141 | $38.3M | 2.3M | $20.9M | 1.6M | +636,230+39.07% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #148 | $36.5M | 2.2M | $34.6M | 2.7M | -548,186-20.28% | Reduce |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC |
| 0.15% | 0.08% | #32 | $35.0M | 2.1M | $20.7M | 1.6M | +454,822+28.22% | Add |
| Contrarius Group Holdings Ltd |
| 1.52% | 1.39% | #5 | $33.1M | 2.0M | $24.5M | 1.9M | +43,389+2.27% | Add |
| JUPITER ASSET MANAGEMENT LTD |
| 0.16% | 0.12% | #30 | $31.3M | 1.8M | $22.8M | 1.8M | +68,444+3.84% | Add |
| MORGAN STANLEY |
| <0.01% | 0.01% | #180 | $29.3M | 1.7M | $104.0M | 6.0M | -4.3M-71.24% | Reduce |
| ARMISTICE CAPITAL, LLC |
| 0.31% | 0.08% | #19 | $25.4M | 1.5M | $4.3M | 336,000 | +1.2M+346.43% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| 0.03% | — | #64 | $23.7M | 1.4M | $0 | 0 | +1.4M | New Buy |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #155 | $21.5M | 1.3M | $12.4M | 966,293 | +305,843+31.65% | Add |
| HRT FINANCIAL LP |
| 0.04% | 0.02% | #60 | $21.0M | 1.2M | $6.4M | 502,337 | +740,980+147.51% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #151 | $20.4M | 1.2M | $12.1M | 941,285 | +266,656+28.33% | Add |
| Ghisallo Capital Management LLC |
| 0.12% | — | #34 | $20.3M | 1.2M | $0 | 0 | +1.2M | New Buy |
| Woodline Partners LP |
| 0.06% | 0.01% | #50 | $18.2M | 1.1M | $2.6M | 200,998 | +874,351+435.00% | Add |
| STIFEL FINANCIAL CORP |
| 0.01% | 0.01% | #87 | $17.2M | 1.0M | $13.0M | 1.0M | +1,681+0.17% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #199 | $16.5M | 976,216 | $17.7M | 1.4M | -405,487-29.35% | Reduce |
| BAKER BROS. ADVISORS LP |
| 0.08% | — | #44 | $15.7M | 930,232 | $0 | 0 | +930,232 | New Buy |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #139 | $15.6M | 921,121 | $9.6M | 748,103 | +173,018+23.13% | Add |
| Connor, Clark & Lunn Investment Management Ltd. |
| 0.03% | 0.02% | #69 | $15.2M | 898,963 | $9.6M | 748,636 | +150,327+20.08% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #181 | $13.3M | 788,812 | $14.3M | 1.1M | -328,829-29.42% | Reduce |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd |
| 0.84% | 0.71% | #9 | $13.2M | 777,948 | $9.3M | 724,286 | +53,662+7.41% | Add |
| JACOBS LEVY EQUITY MANAGEMENT, INC |
| 0.04% | <0.01% | #56 | $12.3M | 726,057 | $768,982 | 59,983 | +666,074+1,110.44% | Add |
| FEDERATED HERMES, INC. |
| 0.02% | 0.01% | #83 | $12.3M | 725,970 | $4.7M | 368,617 | +357,353+96.94% | Add |
| RAYMOND JAMES FINANCIAL INC |
| <0.01% | <0.01% | #144 | $11.8M | 699,390 | $7.4M | 576,930 | +122,460+21.23% | Add |
| ROYAL BANK OF CANADA |
| <0.01% | <0.01% | #176 | $11.4M | 673,340 | $6.0M | 465,499 | +207,841+44.65% | Add |
| Marex Group plc |
| 0.04% | 0.05% | #54 | $10.6M | 623,600 | $8.0M | 623,600 | 00.00% | Unchanged |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #212 | $10.3M | 606,150 | $17.3M | 1.4M | -744,907-55.14% | Reduce |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #123 | $9.8M | 577,825 | $7.4M | 579,430 | -1,605-0.28% | Reduce |
| Caption Management, LLC |
| 0.04% | 0.04% | #55 | $9.5M | 562,700 | $7.5M | 584,900 | -22,200-3.80% | Reduce |
| Point72 Asset Management, L.P. |
| 0.01% | <0.01% | #96 | $9.2M | 542,163 | $3.8M | 297,011 | +245,152+82.54% | Add |
| Vestmark Advisory Solutions, Inc. |
| 0.08% | 0.08% | #43 | $9.0M | 532,817 | $7.1M | 550,144 | -17,327-3.15% | Reduce |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #243 | $8.9M | 527,662 | $6.4M | 548,491 | -20,829-3.80% | Reduce |
| AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #147 | $8.3M | 492,954 | $8.1M | 630,529 | -137,575-21.82% | Reduce |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #149 | $8.3M | 491,226 | $904,566 | 70,559 | +420,667+596.19% | Add |
| Invesco Ltd. |
| <0.01% | <0.01% | #236 | $7.0M | 412,010 | $5.6M | 434,753 | -22,743-5.23% | Reduce |
