| Avoro Capital Advisors LLC |
| 2.78% | 0.96% | #11 | $309.9M | 6.7M | $97.4M | 6.0M | +768,182+12.89% | Add |
| JPMORGAN CHASE & CO |
| 0.01% | <0.01% | #109 | $230.8M | 4.9M | $41.8M | 2.8M | +2.0M+71.55% | Add |
| RTW INVESTMENTS, LP |
| 1.55% | 0.42% | #20 | $181.5M | 3.9M | $42.3M | 2.6M | +1.4M+52.40% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| 0.01% | 0.01% | #112 | $161.0M | 3.5M | $59.6M | 3.6M | -149,503-4.10% | Reduce |
| STATE STREET CORP |
| <0.01% | <0.01% | #138 | $133.8M | 2.9M | $37.0M | 2.3M | +643,313+28.46% | Add |
| Aberdeen Group plc |
| 0.18% | 0.14% | #53 | $131.2M | 2.8M | $86.8M | 5.3M | -2.5M-46.33% | Reduce |
| CITADEL ADVISORS LLC |
| 0.01% | <0.01% | #107 | $115.5M | 2.5M | $29.9M | 1.8M | +676,173+36.93% | Add |
| JANE STREET GROUP, LLC |
| 0.01% | <0.01% | #124 | $103.6M | 2.2M | $17.3M | 1.1M | +1.2M+113.16% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #179 | $86.5M | 1.9M | $28.3M | 1.7M | +143,995+8.31% | Add |
| Caption Management, LLC |
| 0.4% | 0.24% | #41 | $84.9M | 1.8M | $41.3M | 2.5M | -681,531-26.99% | Reduce |
| ORBIMED ADVISORS LLC |
| 1.57% | 0.69% | #19 | $83.3M | 1.8M | $34.9M | 2.1M | -328,663-15.39% | Reduce |
| JENNISON ASSOCIATES LLC |
| 0.04% | 0.01% | #84 | $71.9M | 1.6M | $20.2M | 1.2M | +327,623+26.55% | Add |
| Boxer Capital Management, LLC |
| 5.21% | 1.42% | #5 | $69.2M | 1.5M | $10.8M | 662,000 | +841,300+127.08% | Add |
| GOLDMAN SACHS GROUP INC |
| 0.01% | <0.01% | #133 | $68.0M | 1.5M | $20.7M | 1.3M | +212,720+16.84% | Add |
| TWO SIGMA INVESTMENTS, LP |
| 0.05% | 0.04% | #81 | $67.3M | 1.5M | $43.8M | 2.7M | -1.2M-45.36% | Reduce |
| Two Seas Capital LP |
| 1.31% | 0.3% | #22 | $66.4M | 1.4M | $21.3M | 1.3M | +141,410+10.88% | Add |
| Nantahala Capital Management, LLC |
| 2.17% | 1.71% | #16 | $65.3M | 1.4M | $46.4M | 2.8M | -1.4M-50.05% | Reduce |
| FMR LLC |
| <0.01% | <0.01% | #155 | $58.5M | 1.3M | $28.5M | 1.7M | -473,740-27.17% | Reduce |
| MAK CAPITAL ONE LLC |
| 7.95% | 1.06% | #3 | $56.7M | 1.2M | $7.2M | 441,205 | +790,846+179.25% | Add |
| MPM BioImpact LLC |
| 3.44% | 1.73% | #7 | $56.5M | 1.2M | $22.4M | 1.4M | -143,376-10.47% | Reduce |
| TUDOR INVESTMENT CORP ET AL |
| 0.07% | 0.01% | #71 | $49.8M | 1.1M | $6.5M | 400,500 | +680,689+169.96% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #154 | $49.1M | 1.1M | $18.8M | 321,501 | +745,138+231.77% | Add |
| Vestal Point Capital, LP |
| 1.01% | 0.16% | #25 | $43.1M | 935,000 | $5.9M | 358,996 | +576,004+160.45% | Add |
| MAVERICK CAPITAL LTD |
| 0.38% | 0.13% | #43 | $42.6M | 925,383 | $11.4M | 697,640 | +227,743+32.64% | Add |
| Fiera Capital Corp |
| 0.15% | 0.05% | #58 | $41.9M | 909,141 | $13.4M | 816,893 | +92,248+11.29% | Add |
| Integral Health Asset Management, LLC |
| 1.64% | 0.7% | #18 | $41.5M | 900,000 | $14.7M | 900,000 | 00.00% | Unchanged |
| 683 Capital Management, LLC |
| 2.02% | 1.5% | #17 | $41.0M | 891,200 | $28.7M | 1.8M | -862,400-49.18% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #168 | $39.7M | 860,631 | $13.2M | 804,610 | +56,021+6.96% | Add |
| CITIGROUP INC |
| 0.01% | 0.02% | #113 | $37.5M | 813,944 | $46.0M | 2.8M | -2.0M-71.05% | Reduce |
| Longaeva Partners L.P. |
| 0.81% | — | #29 | $37.1M | 804,594 | $0 | 0 | +804,594 | New Buy |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #194 | $35.9M | 779,779 | $11.4M | 694,721 | +85,058+12.24% | Add |
| Invesco Ltd. |
| <0.01% | — | #163 | $28.9M | 627,823 | $0 | 0 | +627,823 | New Buy |
| First Turn Management, LLC |
| 3% | 1.12% | #10 | $28.0M | 608,925 | $10.1M | 615,489 | -6,564-1.07% | Reduce |
| Point72 Asset Management, L.P. |
| 0.03% | — | #91 | $27.9M | 606,212 | $0 | 0 | +606,212 | New Buy |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.03% | 0.02% | #89 | $27.0M | 586,582 | $15.8M | 964,290 | -377,708-39.17% | Reduce |
| Kinetic Partners Management, LP |
| 0.64% | — | #33 | $26.8M | 581,000 | $0 | 0 | +581,000 | New Buy |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #172 | $26.7M | 578,786 | $4.0M | 246,851 | +331,935+134.47% | Add |
| MILLENNIUM MANAGEMENT LLC |
| 0.01% | 0.01% | #125 | $25.0M | 542,926 | $13.0M | 792,756 | -249,830-31.51% | Reduce |
| DIADEMA PARTNERS LP |
| 3.04% | 1.61% | #9 | $24.6M | 534,400 | $9.5M | 580,200 | -45,800-7.89% | Reduce |
| GILDER GAGNON HOWE & CO LLC |
| 0.25% | — | #49 | $24.5M | 530,979 | $0 | 0 | +530,979 | New Buy |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. |
| 1.32% | 0.72% | #21 | $24.0M | 521,677 | $8.5M | 521,677 | 00.00% | Unchanged |
| Assenagon Asset Management S.A. |
| 0.03% | <0.01% | #92 | $23.7M | 513,530 | $2.4M | 146,749 | +366,781+249.94% | Add |
| READYSTATE ASSET MANAGEMENT LP |
| 1.18% | 0.37% | #23 | $23.2M | 504,702 | $8.3M | 504,702 | 00.00% | Unchanged |
| UBS Group AG |
| <0.01% | <0.01% | #150 | $21.5M | 467,571 | $8.2M | 502,838 | -35,267-7.01% | Reduce |
| Voss Capital, LP |
| 0.96% | 0.57% | #27 | $20.7M | 450,361 | $10.7M | 655,000 | -204,639-31.24% | Reduce |
| Rubric Capital Management LP |
| 0.17% | — | #54 | $18.8M | 408,581 | $0 | 0 | +408,581 | New Buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #157 | $18.6M | 403,338 | $6.1M | 375,852 | +27,486+7.31% | Add |
| Creek Drive Management Group LLC |
| 8.65% | 0.74% | #2 | $17.8M | 387,000 | $3.3M | 200,000 | +187,000+93.50% | Add |
| Affinity Asset Advisors, LLC |
| 0.78% | 0.25% | #30 | $17.3M | 375,000 | $4.9M | 300,000 | +75,000+25.00% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #140 | $17.0M | 369,607 | $5.4M | 332,523 | +37,084+11.15% | Add |
