| FMR LLC |
| 0.04% | 0.05% | #98 | $993.9M | 25.7M | $890.0M | 23.1M | +2.6M+11.06% | Add |
| BlackRock, Inc. |
| 0.01% | 0.01% | #143 | $671.5M | 17.4M | $617.6M | 16.0M | +1.3M+8.15% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.01% | 0.01% | #135 | $312.4M | 8.1M | $282.3M | 7.3M | +739,078+10.08% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| 0.01% | 0.01% | #169 | $286.9M | 7.4M | $265.4M | 6.9M | +517,371+7.50% | Add |
| STATE STREET CORP |
| 0.01% | 0.01% | #151 | $269.5M | 7.0M | $218.0M | 5.7M | +1.3M+22.98% | Add |
| Jupiter Topco LLC |
| 0.1% | — | #76 | $256.4M | 6.6M | $0 | 0 | +6.6M | New Buy |
| Fairmount Funds Management LLC |
| 14.08% | 15.3% | #1 | $213.0M | 5.5M | $211.8M | 5.5M | 00.00% | Unchanged |
| DEERFIELD MANAGEMENT COMPANY, L.P. |
| 2.02% | 4.11% | #19 | $193.7M | 5.0M | $348.1M | 9.0M | -4.0M-44.65% | Reduce |
| TCG Crossover Management, LLC |
| 4.52% | 5.45% | #10 | $187.9M | 4.9M | $190.4M | 4.9M | -92,458-1.87% | Reduce |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.02% | 0.01% | #119 | $180.1M | 4.7M | $123.7M | 3.2M | +1.4M+44.82% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| 0.01% | 0.01% | #148 | $174.5M | 4.5M | $142.4M | 3.7M | +809,479+21.88% | Add |
| WELLINGTON MANAGEMENT GROUP LLP |
| 0.03% | 0.03% | #110 | $168.1M | 4.3M | $137.7M | 3.6M | +765,355+21.39% | Add |
| Kynam Capital Management, LP |
| 7.84% | 9.59% | #6 | $141.9M | 3.7M | $155.4M | 4.0M | -370,234-9.17% | Reduce |
| LORD, ABBETT & CO. LLC |
| 0.38% | 0.4% | #48 | $132.8M | 3.4M | $122.4M | 3.2M | +249,760+7.85% | Add |
| Polar Capital Holdings Plc |
| 0.3% | — | #55 | $125.1M | 3.2M | $0 | 0 | +3.2M | New Buy |
| Commodore Capital LP |
| 7.03% | 6.43% | #7 | $118.0M | 3.1M | $111.2M | 2.9M | +161,993+5.61% | Add |
| Invesco Ltd. |
| 0.01% | 0.01% | #152 | $101.0M | 2.6M | $93.5M | 2.4M | +179,512+7.39% | Add |
| Woodline Partners LP |
| 0.31% | 0.22% | #52 | $100.7M | 2.6M | $58.1M | 1.5M | +1.1M+72.45% | Add |
| Pictet Asset Management Holding SA |
| 0.09% | 0.07% | #81 | $92.6M | 2.4M | $68.8M | 1.8M | +594,747+33.06% | Add |
| Octagon Capital Advisors LP |
| 8.17% | 10.01% | #5 | $90.9M | 2.4M | $90.5M | 2.4M | 00.00% | Unchanged |
| RTW INVESTMENTS, LP |
| 0.76% | 2.09% | #39 | $89.4M | 2.3M | $210.1M | 5.5M | -3.1M-57.70% | Reduce |
| GOLDMAN SACHS GROUP INC |
| 0.01% | 0.02% | #155 | $88.6M | 2.3M | $170.7M | 4.4M | -2.1M-48.39% | Reduce |
| Candriam S.C.A. |
| 0.36% | 0.23% | #49 | $80.7M | 2.1M | $46.1M | 1.3M | +791,894+61.08% | Add |
| Deep Track Capital, LP |
| 1.13% | 0.63% | #31 | $77.4M | 2.0M | $38.5M | 1.0M | +1.0M+100.00% | Add |
| Siren, L.L.C. |
| 1.46% | 1.82% | #27 | $72.0M | 1.9M | $65.8M | 1.7M | +150,000+8.78% | Add |
| ORBIMED ADVISORS LLC |
| 1.23% | 0.25% | #30 | $65.1M | 1.7M | $12.4M | 322,100 | +1.4M+421.98% | Add |
| Venrock Adviser, LLC |
| 1.93% | 2.87% | #20 | $63.6M | 1.6M | $77.0M | 2.0M | -357,834-17.89% | Reduce |
| EMERALD ADVISERS, LLC |
| 1.46% | 1.93% | #26 | $62.0M | 1.6M | $61.1M | 1.6M | +15,187+0.96% | Add |
| NORTHERN TRUST CORP |
| 0.01% | 0.01% | #161 | $60.3M | 1.6M | $47.9M | 1.2M | +312,079+25.05% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| 0.01% | 0.01% | #156 | $56.1M | 1.4M | $47.8M | 1.2M | +206,978+16.66% | Add |
| Assenagon Asset Management S.A. |
| 0.07% | 0.02% | #87 | $55.8M | 1.4M | $11.4M | 295,650 | +1.1M+387.66% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #198 | $55.7M | 1.4M | $40.2M | 1.0M | +395,827+37.92% | Add |
| AMERICAN CENTURY COMPANIES INC |
| 0.02% | 0.02% | #112 | $55.5M | 1.4M | $34.3M | 890,568 | +542,389+60.90% | Add |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 5.15% | 5.16% | #8 | $49.6M | 1.3M | $50.6M | 1.3M | -33,482-2.55% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| 0.01% | 0.01% | #142 | $47.0M | 1.2M | $40.7M | 1.1M | +155,423+14.69% | Add |
| Elmind Capital, LP |
| 11.38% | 12.79% | #2 | $45.3M | 1.2M | $45.1M | 1.2M | 00.00% | Unchanged |
| UBS Group AG |
| 0.01% | <0.01% | #175 | $43.4M | 1.1M | $11.2M | 291,486 | +830,759+285.01% | Add |
| FRED ALGER MANAGEMENT, LLC |
| 0.14% | 0.21% | #72 | $41.5M | 1.1M | $47.7M | 1.2M | -166,870-13.46% | Reduce |
| CITADEL ADVISORS LLC |
| <0.01% | 0.01% | #185 | $41.5M | 1.1M | $73.4M | 1.9M | -834,733-43.76% | Reduce |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #204 | $41.4M | 1.1M | $30.9M | 803,878 | +265,688+33.05% | Add |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.05% | 0.04% | #95 | $40.8M | 1.1M | $33.0M | 856,598 | +198,245+23.14% | Add |
| Sofinnova Investments, Inc. |
| 2.07% | 3.09% | #17 | $40.1M | 1.0M | $81.4M | 2.1M | -1.1M-51.02% | Reduce |
| EMERALD MUTUAL FUND ADVISERS TRUST |
| 1.4% | 1.92% | #28 | $39.9M | 1.0M | $39.6M | 1.0M | +2,546+0.25% | Add |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
| 0.01% | 0.01% | #136 | $39.6M | 1.0M | $17.3M | 449,482 | +572,701+127.41% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| 0.05% | 0.04% | #94 | $38.6M | 996,168 | $27.2M | 706,268 | +289,900+41.05% | Add |
| VOYA INVESTMENT MANAGEMENT LLC |
| 0.03% | 0.03% | #107 | $36.9M | 952,757 | $25.6M | 664,146 | +288,611+43.46% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #225 | $36.4M | 941,725 | $18.5M | 1.3M | -346,439-26.89% | Reduce |
| D. E. Shaw & Co., Inc. |
| 0.02% | 0.04% | #122 | $35.7M | 922,479 | $71.9M | 1.9M | -945,910-50.63% | Reduce |
| MILLENNIUM MANAGEMENT LLC |
| 0.01% | 0.02% | #137 | $35.1M | 907,712 | $45.9M | 1.2M | -284,694-23.88% | Reduce |
| Logos Global Management LP |
| 1.5% | — | #24 | $34.8M | 900,000 | $0 | 0 | +900,000 | New Buy |
