PRAXIS PRECISION MEDICINES I PRAX
10.23% 12.82% $681.6M 2.0M $656.0M 2.0M 0 0.00% Unchanged S SPYRE THERAPEUTICS INC SYRE
5.76% 3.73% $383.5M 4.3M $190.8M 3.8M +536,271 +14.17% Add CELCUITY INC CELC
5.02% 6.97% $334.5M 3.2M $356.9M 3.1M +70,000 +2.24% Add A ASCENDIS PHARMA A/S SPONSORED ADR ASND
4.66% 6.84% $310.4M 1.2M $350.3M 1.5M -367,700 -24.01% Reduce RHYTHM PHARMACEUTICALS INC RYTM
4.31% 4.03% $287.2M 2.6M $206.4M 2.4M +212,500 +8.95% Add ROIVANT SCIENCES LTD ROIV
4.3% 4.48% $286.1M 8.1M $229.5M 8.3M -200,000 -2.41% Reduce RELAY THERAPEUTICS INC RLAY
3.96% 1.9% $263.9M 14.1M $97.0M 9.8M +4.4M +44.66% Add T TRAVERE THERAPEUTICS INC TVTX
3.2% 2.4% $213.2M 3.8M $123.1M 4.1M -389,977 -9.41% Reduce K KARDIGAN INC KARD
2.94% — $195.6M 8.2M $0 0 +8.2M New Buy N NUVALENT INC NUVL
2.93% 3.16% $195.2M 1.6M $161.9M 1.6M 0 0.00% Unchanged EDGEWISE THERAPEUTICS INC EWTX
2.67% 2.72% $177.7M 4.4M $139.4M 4.4M -50,000 -1.13% Reduce APOGEE THERAPEUTICS INC APGE
2.61% 2.53% $173.6M 1.3M $129.7M 1.5M -232,271 -15.08% Reduce A AMYLYX PHARMACEUTICALS INC AMLX
2.25% 2.25% $149.7M 8.3M $115.2M 8.3M +50,000 +0.60% Add MEIRAGTX HLDGS PLC MGTX
2.19% 1.75% $145.7M 10.8M $89.3M 10.3M +460,555 +4.46% Add O ORUKA THERAPEUTICS INC COM ORKA
1.92% 1.34% $128.0M 1.3M $68.4M 1.4M -50,438 -3.61% Reduce INHIBRX BIOSCIENCES INC INBX
1.85% 1.9% $123.0M 1.3M $97.0M 1.4M -144,944 -10.05% Reduce P PROTAGONIST THERAPEUTICS INC PTGX
1.81% 2.54% $120.4M 981,879 $129.7M 1.2M -249,000 -20.23% Reduce SOLID BIOSCIENCES INC SLDB
1.79% 1.68% $118.9M 11.9M $85.7M 11.9M 0 0.00% Unchanged ZYMEWORKS INC ZYME
1.64% 1.72% $109.3M 4.2M $87.9M 3.5M +672,875 +19.17% Add T TANGO THERAPEUTICS INC TNGX
1.58% 0.33% $105.6M 3.4M $16.9M 808,153 +2.6M +317.87% Add IMMATICS N.V IMTX
1.58% 2% $105.2M 10.4M $102.2M 10.4M 0 0.00% Unchanged NURIX THERAPEUTICS INC NRIX
1.57% 1.12% $104.8M 4.3M $57.5M 3.7M +609,545 +16.43% Add BIOCRYST PHARMACEUTICALS INC BCRX
1.55% 1.38% $103.1M 10.3M $70.8M 7.4M +2.9M +38.67% Add R REVOLUTION MEDICINES INC COM RVMD
1.48% 0.49% $98.8M 527,600 $25.1M 258,600 +269,000 +104.02% Add A AVALYN PHARMACEUTICALS INC AVLN
1.32% — $88.1M 2.7M $0 0 +2.7M New Buy MODERNA INC MRNA
1.05% 0.99% $70.0M 1.0M $50.8M 1.0M 0 0.00% Unchanged D DYNE THERAPEUTICS INC DYN
0.9% 1.65% $59.7M 2.7M $84.6M 4.7M -2.0M -42.40% Reduce BIOGEN INC BIIB
0.9% — $59.7M 276,173 $0 0 +276,173 New Buy I IMMUNOVANT INC IMVT
0.79% 0.78% $52.3M 1.4M $39.7M 1.6M -240,000 -15.02% Reduce UNITEDHEALTH GROUP INC UNH
0.73% — $48.5M 116,806 $0 0 +116,806 New Buy S STATE STREET SPDR S&P BIOTECH ETF XBI
0.71% — $47.5M 300,000 $0 0 +300,000 New Buy IONIS PHARMACEUTICALS INC IONS
0.67% 0.74% $44.9M 566,000 $37.8M 504,000 +62,000 +12.30% Add S SUTRO BIOPHARMA INC STRO
0.65% 0.35% $43.3M 1.3M $17.8M 715,307 +589,539 +82.42% Add A ALTO NEUROSCIENCE INC COM SHS ANRO
0.64% 0.88% $42.5M 1.6M $45.2M 2.0M -400,000 -19.90% Reduce JAZZ PHARMACEUTICALS PLC JAZZ
0.61% 0.63% $41.0M 170,000 $32.1M 170,000 0 0.00% Unchanged CORVUS PHARMACEUTICALS I CRVS
0.6% 0.66% $39.9M 2.7M $33.5M 2.3M +375,000 +16.36% Add S SIONNA THERAPEUTICS INC SION
0.6% 0.52% $39.8M 905,000 $26.4M 658,439 +246,561 +37.45% Add CYTOMX THERAPEUTICS INC. CTMX
0.59% 0.93% $39.1M 10.4M $47.5M 10.1M +340,361 +3.37% Add A ARTIVION INC AORT
0.59% 1.17% $39.0M 1.7M $60.0M 1.6M +100,000 +6.11% Add X X4 Pharmaceuticals Inc XFOR
0.56% 0.54% $37.0M 7.9M $27.8M 6.7M +1.2M +17.75% Add C CAPRICOR THERAPEUTICS INC COM NEW CAPR
0.54% — $36.1M 1.5M $0 0 +1.5M New Buy C CORCEPT THERAPEUTICS INC CORT
0.52% 0.04% $34.6M 398,385 $2.0M 50,000 +348,385 +696.77% Add R REPLIGEN CORP RGEN
0.51% 0.65% $33.9M 248,212 $33.1M 280,541 -32,329 -11.52% Reduce A ANTERIS TECHNOLOGIES GLOBAL COM AVR
0.51% 0.37% $33.7M 3.4M $19.0M 3.4M 0 0.00% Unchanged R RAPPORT THERAPEUTICS INC RAPP
0.48% 0.41% $32.2M 773,342 $21.1M 673,923 +99,419 +14.75% Add D DAMORA THERAPEUTICS INC DMRA
0.48% 0.62% $31.8M 1.2M $31.7M 1.2M 0 0.00% Unchanged C CHARLES RIV LABS INTL INC CRL
0.48% — $31.8M 140,000 $0 0 +140,000 New Buy AXSOME THERAPEUTICS INC. AXSM
0.44% 0.5% $29.0M 118,450 $25.3M 149,950 -31,500 -21.01% Reduce E EYEPOINT INC EYPT
0.43% — $28.6M 2.0M $0 0 +2.0M New Buy DBV TECHNOLOGIES S A DBVT
0.41% 0.39% $27.1M 1.7M $20.1M 964,391 +688,959 +71.44% Add 
